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Freeze the header row of a long table when scrolling

Source: R/FreezeTableHeader.R
FreezeTableHeader.Rd

Render a table with a "sticky" header row that stays visible while the reader scrolls, so the column meanings are never lost in a long table. This is handy for the tall tables produced by MakeComparisonTable() and other gtsummary helpers when they are knit into HTML Quarto or R Markdown documents.

Usage

FreezeTableHeader(
  x,
  height = NULL,
  width = NULL,
  header_background = "white",
  bootstrap_options = c("striped", "hover", "condensed"),
  full_width = FALSE,
  font_size = NULL,
  ...
)

Arguments

x

A gtsummary object (such as the output of MakeComparisonTable()), a data frame or tibble, or an existing kableExtra / knitr_kable object.

height

Optional CSS height for a scroll box, for example "400px" or "60vh". When supplied, the table scrolls within a box of this height with the header frozen. When NULL (default), the header sticks during page-level scrolling instead.

width

Optional CSS width for the scroll box, for example "100%". Only used when height is supplied.

header_background

Background color for the frozen header row. Defaults to "white" so the header cleanly covers rows scrolling underneath it.

bootstrap_options

Character vector of kableExtra bootstrap styling options passed to kableExtra::kable_styling(). Defaults to c("striped", "hover", "condensed").

full_width

Logical; passed to kableExtra::kable_styling(). Default FALSE.

font_size

Optional numeric font size passed to kableExtra::kable_styling().

...

Additional arguments passed to kableExtra::kable_styling().

Value

A kableExtra HTML table object with a frozen header, suitable for printing in a Quarto or R Markdown chunk.

Details

The table is rendered through kableExtra with kable_styling(fixed_thead = ...), which pins the header row using CSS position: sticky. Two scrolling modes are supported:

  • With height = NULL (the default) the header sticks to the top of the viewport as the whole page scrolls past the table.

  • With a height (for example "400px") the table is placed in its own scroll box of that height and the header stays frozen at the top of the box.

Sticky headers only take effect in HTML output. In PDF or Word output the table renders normally without a frozen header.

See also

MakeComparisonTable()

Examples

# \donttest{
data(SampleData)
data(SampleVariableTypes)

Labelled <- RevalueData(SampleData, SampleVariableTypes)$RevaluedData

# Repeat the full comparison table to make scrolling and the frozen header
# obvious on the reference page.
tbl_Base <- MakeComparisonTable(
  data = Labelled,
  group_var = "Diagnosis",
  variables = setdiff(names(Labelled), "Diagnosis")
)

tbl_All <- dplyr::bind_rows(rep(list(tbl_Base$table_body), 8))

# Inside a fixed-height vertical scroll box
htmltools::browsable(htmltools::HTML(as.character(
  FreezeTableHeader(tbl_All, height = "450px", width = "100%")
)))

 variable 
    var_type 
    row_type 
    var_label 
    label 
    stat_1 
    stat_2 
    p_unadj 
    p_adj 
    test_label 
    Notes 
    .is_main_row 
    p.value 
    p.value_fmt 
    Test 
  
 age 
    continuous 
    label 
    Age 
    Age 
    72.75 (13.26) 
    71.78 (13.12) 
    0.5526369 
    NA 
    Welch t-test 
    NA 
    TRUE 
    0.5526369 
    0.553 
    Welch t-test 
  
 sex 
    categorical 
    label 
    Sex 
    Sex 
    NA 
    NA 
    0.0272353 
    NA 
    Pearson chi-squared 
    NA 
    TRUE 
    0.0272353 
    0.0272 
    Pearson chi-squared 
  
 sex 
    categorical 
    level 
    Sex 
    Female 
    157 (65%) 
    47 (52%) 
    0.0272353 
    NA 
    Pearson chi-squared 
    NA 
    FALSE 
    0.0272353 
    NA 
    NA 
  
 sex 
    categorical 
    level 
    Sex 
    Male 
    85 (35%) 
    44 (48%) 
    0.0272353 
    NA 
    Pearson chi-squared 
    NA 
    FALSE 
    0.0272353 
    NA 
    NA 
  
 Genotype 
    categorical 
    label 
    Genotype 
    Genotype 
    NA 
    NA 
    0.0005999 
    NA 
    Fisher (sim.) 
    NA 
    TRUE 
    0.0005999 
    <0.001 
    Fisher (sim.) 
  
 Genotype 
    categorical 
    level 
    Genotype 
    E2E2 
    2 (0.8%) 
    0 (0%) 
    0.0005999 
    NA 
    Fisher (sim.) 
    NA 
    FALSE 
    0.0005999 
    NA 
    NA 
  
 Genotype 
    categorical 
    level 
    Genotype 
    E2E3 
    30 (12%) 
    7 (7.7%) 
    0.0005999 
    NA 
    Fisher (sim.) 
    NA 
    FALSE 
    0.0005999 
    NA 
    NA 
  
 Genotype 
    categorical 
    level 
    Genotype 
    E2E4 
    7 (2.9%) 
    1 (1.1%) 
    0.0005999 
    NA 
    Fisher (sim.) 
    NA 
    FALSE 
    0.0005999 
    NA 
    NA 
  
 Genotype 
    categorical 
    level 
    Genotype 
    E3E3 
    133 (55%) 
    34 (37%) 
    0.0005999 
    NA 
    Fisher (sim.) 
    NA 
    FALSE 
    0.0005999 
    NA 
    NA 
  
 Genotype 
    categorical 
    level 
    Genotype 
    E3E4 
    65 (27%) 
    41 (45%) 
    0.0005999 
    NA 
    Fisher (sim.) 
    NA 
    FALSE 
    0.0005999 
    NA 
    NA 
  
 Genotype 
    categorical 
    level 
    Genotype 
    E4E4 
    5 (2.1%) 
    8 (8.8%) 
    0.0005999 
    NA 
    Fisher (sim.) 
    NA 
    FALSE 
    0.0005999 
    NA 
    NA 
  
 ACE_CD143_Angiotensin_Converti 
    continuous 
    label 
    Angiotensin-converting enzyme 
    Angiotensin-converting enzyme 
    1.32 (0.56) 
    1.31 (0.53) 
    0.8846265 
    NA 
    Welch t-test 
    NA 
    TRUE 
    0.8846265 
    0.885 
    Welch t-test 
  
 ACTH_Adrenocorticotropic_Hormon 
    continuous 
    label 
    Adrenocorticotropic hormone 
    Adrenocorticotropic hormone 
    -1.55 (0.27) 
    -1.51 (0.29) 
    0.3228133 
    NA 
    Welch t-test 
    NA 
    TRUE 
    0.3228133 
    0.323 
    Welch t-test 
  
 AXL 
    continuous 
    label 
    AXL receptor tyrosine kinase 
    AXL receptor tyrosine kinase 
    0.28 (0.46) 
    0.34 (0.41) 
    0.2384182 
    NA 
    Welch t-test 
    NA 
    TRUE 
    0.2384182 
    0.238 
    Welch t-test 
  
 Adiponectin 
    continuous 
    label 
    Adiponectin 
    Adiponectin 
    -5.26 (0.65) 
    -5.10 (0.69) 
    0.0538971 
    NA 
    Welch t-test 
    NA 
    TRUE 
    0.0538971 
    0.0539 
    Welch t-test 
  
 Alpha_1_Antichymotrypsin 
    continuous 
    label 
    Alpha-1-antichymotrypsin 
    Alpha-1-antichymotrypsin 
    1.32 (0.36) 
    1.44 (0.37) 
    0.0096393 
    NA 
    Welch t-test 
    NA 
    TRUE 
    0.0096393 
    0.00964 
    Welch t-test 
  
 Alpha_1_Antitrypsin 
    continuous 
    label 
    Alpha-1-antitrypsin 
    Alpha-1-antitrypsin 
    -13.33 (1.51) 
    -12.62 (1.52) 
    0.0001841 
    NA 
    Welch t-test 
    NA 
    TRUE 
    0.0001841 
    <0.001 
    Welch t-test 
  
 Alpha_1_Microglobulin 
    continuous 
    label 
    Alpha-1-microglobulin 
    Alpha-1-microglobulin 
    -2.99 (0.48) 
    -2.82 (0.45) 
    0.0030400 
    NA 
    Welch t-test 
    NA 
    TRUE 
    0.0030400 
    0.00304 
    Welch t-test 
  
 Alpha_2_Macroglobulin 
    continuous 
    label 
    Alpha-2-macroglobulin 
    Alpha-2-macroglobulin 
    -162.49 (41.36) 
    -151.41 (38.78) 
    0.0237020 
    NA 
    Welch t-test 
    NA 
    TRUE 
    0.0237020 
    0.0237 
    Welch t-test 
  
 Angiopoietin_2_ANG_2 
    continuous 
    label 
    Angiopoietin-2 
    Angiopoietin-2 
    0.65 (0.33) 
    0.70 (0.34) 
    0.2243927 
    NA 
    Welch t-test 
    NA 
    TRUE 
    0.2243927 
    0.224 
    Welch t-test 
  
 Angiotensinogen 
    continuous 
    label 
    Angiotensinogen 
    Angiotensinogen 
    2.31 (0.25) 
    2.38 (0.25) 
    0.0363220 
    NA 
    Welch t-test 
    NA 
    TRUE 
    0.0363220 
    0.0363 
    Welch t-test 
  
 Apolipoprotein_A_IV 
    continuous 
    label 
    Apolipoprotein A-IV 
    Apolipoprotein A-IV 
    -1.86 (0.39) 
    -1.84 (0.37) 
    0.6196039 
    NA 
    Welch t-test 
    NA 
    TRUE 
    0.6196039 
    0.62 
    Welch t-test 
  
 Apolipoprotein_A1 
    continuous 
    label 
    Apolipoprotein A-1 
    Apolipoprotein A-1 
    -7.48 (0.43) 
    -7.50 (0.44) 
    0.6901145 
    NA 
    Welch t-test 
    NA 
    TRUE 
    0.6901145 
    0.69 
    Welch t-test 
  
 Apolipoprotein_A2 
    continuous 
    label 
    Apolipoprotein A-2 
    Apolipoprotein A-2 
    -0.66 (0.50) 
    -0.61 (0.48) 
    0.3909281 
    NA 
    Welch t-test 
    NA 
    TRUE 
    0.3909281 
    0.391 
    Welch t-test 
  
 Apolipoprotein_B 
    continuous 
    label 
    Apolipoprotein B 
    Apolipoprotein B 
    -5.71 (1.40) 
    -5.27 (1.55) 
    0.0183210 
    NA 
    Welch t-test 
    NA 
    TRUE 
    0.0183210 
    0.0183 
    Welch t-test 
  
 Apolipoprotein_CI 
    continuous 
    label 
    Apolipoprotein C-I 
    Apolipoprotein C-I 
    -1.60 (0.41) 
    -1.58 (0.45) 
    0.8186647 
    NA 
    Welch t-test 
    NA 
    TRUE 
    0.8186647 
    0.819 
    Welch t-test 
  
 Apolipoprotein_CIII 
    continuous 
    label 
    Apolipoprotein C-III 
    Apolipoprotein C-III 
    -2.53 (0.44) 
    -2.42 (0.44) 
    0.0350373 
    NA 
    Welch t-test 
    NA 
    TRUE 
    0.0350373 
    0.035 
    Welch t-test 
  
 Apolipoprotein_D 
    continuous 
    label 
    Apolipoprotein D 
    Apolipoprotein D 
    1.39 (0.33) 
    1.54 (0.38) 
    0.0015555 
    NA 
    Welch t-test 
    NA 
    TRUE 
    0.0015555 
    0.00156 
    Welch t-test 
  
 Apolipoprotein_E 
    continuous 
    label 
    Apolipoprotein E 
    Apolipoprotein E 
    2.79 (0.77) 
    2.78 (0.87) 
    0.8668217 
    NA 
    Welch t-test 
    NA 
    TRUE 
    0.8668217 
    0.867 
    Welch t-test 
  
 Apolipoprotein_H 
    continuous 
    label 
    Apolipoprotein H 
    Apolipoprotein H 
    -0.35 (0.38) 
    -0.23 (0.38) 
    0.0106232 
    NA 
    Welch t-test 
    NA 
    TRUE 
    0.0106232 
    0.0106 
    Welch t-test 
  
 B_Lymphocyte_Chemoattractant_BL 
    continuous 
    label 
    B-lymphocyte chemoattractant 
    B-lymphocyte chemoattractant 
    1.92 (0.57) 
    2.16 (0.56) 
    0.0007177 
    NA 
    Welch t-test 
    NA 
    TRUE 
    0.0007177 
    <0.001 
    Welch t-test 
  
 BMP_6 
    continuous 
    label 
    Bone morphogenetic protein 6 
    Bone morphogenetic protein 6 
    -1.89 (0.29) 
    -1.92 (0.33) 
    0.5218752 
    NA 
    Welch t-test 
    NA 
    TRUE 
    0.5218752 
    0.522 
    Welch t-test 
  
 Beta_2_Microglobulin 
    continuous 
    label 
    Beta-2-microglobulin 
    Beta-2-microglobulin 
    0.16 (0.29) 
    0.19 (0.31) 
    0.4233981 
    NA 
    Welch t-test 
    NA 
    TRUE 
    0.4233981 
    0.423 
    Welch t-test 
  
 Betacellulin 
    continuous 
    label 
    Betacellulin 
    Betacellulin 
    51.63 (10.91) 
    50.62 (10.60) 
    0.4399492 
    NA 
    Welch t-test 
    NA 
    TRUE 
    0.4399492 
    0.44 
    Welch t-test 
  
 C_Reactive_Protein 
    continuous 
    label 
    C-reactive protein 
    C-reactive protein 
    -5.87 (1.22) 
    -5.97 (1.14) 
    0.4843525 
    NA 
    Welch t-test 
    NA 
    TRUE 
    0.4843525 
    0.484 
    Welch t-test 
  
 CD40 
    continuous 
    label 
    CD40 
    CD40 
    -1.26 (0.21) 
    -1.28 (0.24) 
    0.5003297 
    NA 
    Welch t-test 
    NA 
    TRUE 
    0.5003297 
    0.5 
    Welch t-test 
  
 CD5L 
    continuous 
    label 
    CD5L 
    CD5L 
    -0.10 (0.44) 
    0.04 (0.49) 
    0.0247260 
    NA 
    Welch t-test 
    NA 
    TRUE 
    0.0247260 
    0.0247 
    Welch t-test 
  
 Calbindin 
    continuous 
    label 
    Calbindin 
    Calbindin 
    21.99 (3.90) 
    22.93 (4.85) 
    0.1011017 
    NA 
    Welch t-test 
    NA 
    TRUE 
    0.1011017 
    0.101 
    Welch t-test 
  
 Calcitonin 
    continuous 
    label 
    Calcitonin 
    Calcitonin 
    1.68 (0.85) 
    1.71 (0.94) 
    0.7808643 
    NA 
    Welch t-test 
    NA 
    TRUE 
    0.7808643 
    0.781 
    Welch t-test 
  
 CgA 
    continuous 
    label 
    Chromogranin A 
    Chromogranin A 
    329.78 (82.65) 
    333.17 (81.12) 
    0.7351867 
    NA 
    Welch t-test 
    NA 
    TRUE 
    0.7351867 
    0.735 
    Welch t-test 
  
 Clusterin_Apo_J 
    continuous 
    label 
    Clusterin (ApoJ) 
    Clusterin (ApoJ) 
    2.85 (0.29) 
    2.95 (0.33) 
    0.0116372 
    NA 
    Welch t-test 
    NA 
    TRUE 
    0.0116372 
    0.0116 
    Welch t-test 
  
 Complement_3 
    continuous 
    label 
    Complement component 3 
    Complement component 3 
    -15.95 (2.45) 
    -14.92 (2.43) 
    0.0007632 
    NA 
    Welch t-test 
    NA 
    TRUE 
    0.0007632 
    <0.001 
    Welch t-test 
  
 Complement_Factor_H 
    continuous 
    label 
    Complement factor H 
    Complement factor H 
    3.48 (1.26) 
    3.62 (1.22) 
    0.3580892 
    NA 
    Welch t-test 
    NA 
    TRUE 
    0.3580892 
    0.358 
    Welch t-test 
  
 Connective_Tissue_Growth_Factor 
    continuous 
    label 
    Connective tissue growth factor 
    Connective tissue growth factor 
    0.76 (0.21) 
    0.79 (0.20) 
    0.2752610 
    NA 
    Welch t-test 
    NA 
    TRUE 
    0.2752610 
    0.275 
    Welch t-test 
  
 Cortisol 
    continuous 
    label 
    Cortisol 
    Cortisol 
    11.22 (3.73) 
    12.93 (4.34) 
    0.0011179 
    NA 
    Welch t-test 
    NA 
    TRUE 
    0.0011179 
    0.00112 
    Welch t-test 
  
 Creatine_Kinase_MB 
    continuous 
    label 
    Creatine kinase-MB 
    Creatine kinase-MB 
    -1.66 (0.10) 
    -1.70 (0.08) 
    0.0001039 
    NA 
    Welch t-test 
    NA 
    TRUE 
    0.0001039 
    <0.001 
    Welch t-test 
  
 Cystatin_C 
    continuous 
    label 
    Cystatin C 
    Cystatin C 
    8.62 (0.40) 
    8.48 (0.40) 
    0.0055073 
    NA 
    Welch t-test 
    NA 
    TRUE 
    0.0055073 
    0.00551 
    Welch t-test 
  
 EGF_R 
    continuous 
    label 
    Epidermal growth factor receptor 
    Epidermal growth factor receptor 
    -0.71 (0.24) 
    -0.68 (0.22) 
    0.4379144 
    NA 
    Welch t-test 
    NA 
    TRUE 
    0.4379144 
    0.438 
    Welch t-test 
  
 EN_RAGE 
    continuous 
    label 
    EN-RAGE (extracellular newly identified RAGE-binding protein) 
    EN-RAGE (extracellular newly identified RAGE-binding protein) 
    -3.62 (0.90) 
    -3.65 (0.88) 
    0.7659387 
    NA 
    Welch t-test 
    NA 
    TRUE 
    0.7659387 
    0.766 
    Welch t-test 
  
 ENA_78 
    continuous 
    label 
    ENA-78 (epithelial-derived neutrophil-activating protein 78) 
    ENA-78 (epithelial-derived neutrophil-activating protein 78) 
    -1.37 (0.01) 
    -1.37 (0.01) 
    0.9254390 
    NA 
    Welch t-test 
    NA 
    TRUE 
    0.9254390 
    0.925 
    Welch t-test 
  
 Eotaxin_3 
    continuous 
    label 
    Eotaxin-3 
    Eotaxin-3 
    55.36 (15.98) 
    63.75 (15.86) 
    0.0000303 
    NA 
    Welch t-test 
    NA 
    TRUE 
    0.0000303 
    <0.001 
    Welch t-test 
  
 FAS 
    continuous 
    label 
    Fas (tumor necrosis factor receptor superfamily member 6) 
    Fas (tumor necrosis factor receptor superfamily member 6) 
    -0.58 (0.28) 
    -0.40 (0.31) 
    0.0000019 
    NA 
    Welch t-test 
    NA 
    TRUE 
    0.0000019 
    <0.001 
    Welch t-test 
  
 FSH_Follicle_Stimulation_Hormon 
    continuous 
    label 
    Follicle-stimulating hormone 
    Follicle-stimulating hormone 
    -1.12 (0.39) 
    -1.15 (0.43) 
    0.6164374 
    NA 
    Welch t-test 
    NA 
    TRUE 
    0.6164374 
    0.616 
    Welch t-test 
  
 Fas_Ligand 
    continuous 
    label 
    Fas ligand 
    Fas ligand 
    2.79 (1.05) 
    3.22 (1.12) 
    0.0015514 
    NA 
    Welch t-test 
    NA 
    TRUE 
    0.0015514 
    0.00155 
    Welch t-test 
  
 Fatty_Acid_Binding_Protein 
    continuous 
    label 
    Fatty acid-binding protein 
    Fatty acid-binding protein 
    1.24 (0.73) 
    1.59 (0.86) 
    0.0007710 
    NA 
    Welch t-test 
    NA 
    TRUE 
    0.0007710 
    <0.001 
    Welch t-test 
  
 Ferritin 
    continuous 
    label 
    Ferritin 
    Ferritin 
    2.70 (0.76) 
    2.90 (0.83) 
    0.0426440 
    NA 
    Welch t-test 
    NA 
    TRUE 
    0.0426440 
    0.0426 
    Welch t-test 
  
 Fetuin_A 
    continuous 
    label 
    Fetuin-A 
    Fetuin-A 
    1.32 (0.40) 
    1.44 (0.34) 
    0.0314522 
    NA 
    Welch t-test 
    NA 
    TRUE 
    0.0314522 
    0.0315 
    Welch t-test 
  
 Fibrinogen 
    continuous 
    label 
    Fibrinogen 
    Fibrinogen 
    -7.45 (0.56) 
    -7.12 (0.57) 
    0.0000075 
    NA 
    Welch t-test 
    NA 
    TRUE 
    0.0000075 
    <0.001 
    Welch t-test 
  
 GRO_alpha 
    continuous 
    label 
    Growth-regulated alpha protein 
    Growth-regulated alpha protein 
    1.37 (0.04) 
    1.40 (0.04) 
    0.0000000 
    NA 
    Welch t-test 
    NA 
    TRUE 
    0.0000000 
    <0.001 
    Welch t-test 
  
 Gamma_Interferon_induced_Monokin 
    continuous 
    label 
    Gamma interferon-induced monokine 
    Gamma interferon-induced monokine 
    2.77 (0.11) 
    2.83 (0.10) 
    0.0000059 
    NA 
    Welch t-test 
    NA 
    TRUE 
    0.0000059 
    <0.001 
    Welch t-test 
  
 Glutathione_S_Transferase_alpha 
    continuous 
    label 
    Glutathione S-transferase alpha 
    Glutathione S-transferase alpha 
    0.95 (0.17) 
    0.96 (0.12) 
    0.5459600 
    NA 
    Welch t-test 
    NA 
    TRUE 
    0.5459600 
    0.546 
    Welch t-test 
  
 HB_EGF 
    continuous 
    label 
    Heparin-binding epidermal growth factor 
    Heparin-binding epidermal growth factor 
    6.70 (1.47) 
    7.20 (1.49) 
    0.0061319 
    NA 
    Welch t-test 
    NA 
    TRUE 
    0.0061319 
    0.00613 
    Welch t-test 
  
 HCC_4 
    continuous 
    label 
    HCC-4 (hemofiltrate CC chemokine-4) 
    HCC-4 (hemofiltrate CC chemokine-4) 
    -3.55 (0.36) 
    -3.40 (0.34) 
    0.0005695 
    NA 
    Welch t-test 
    NA 
    TRUE 
    0.0005695 
    <0.001 
    Welch t-test 
  
 Hepatocyte_Growth_Factor_HGF 
    continuous 
    label 
    Hepatocyte growth factor 
    Hepatocyte growth factor 
    0.17 (0.29) 
    0.27 (0.29) 
    0.0051215 
    NA 
    Welch t-test 
    NA 
    TRUE 
    0.0051215 
    0.00512 
    Welch t-test 
  
 I_309 
    continuous 
    label 
    I-309 (TCA-3) 
    I-309 (TCA-3) 
    2.92 (0.36) 
    3.02 (0.39) 
    0.0337660 
    NA 
    Welch t-test 
    NA 
    TRUE 
    0.0337660 
    0.0338 
    Welch t-test 
  
 ICAM_1 
    continuous 
    label 
    Intercellular adhesion molecule 1 
    Intercellular adhesion molecule 1 
    -0.60 (0.32) 
    -0.56 (0.36) 
    0.3368872 
    NA 
    Welch t-test 
    NA 
    TRUE 
    0.3368872 
    0.337 
    Welch t-test 
  
 IGF_BP_2 
    continuous 
    label 
    Insulin-like growth factor-binding protein 2 
    Insulin-like growth factor-binding protein 2 
    5.28 (0.20) 
    5.38 (0.22) 
    0.0001243 
    NA 
    Welch t-test 
    NA 
    TRUE 
    0.0001243 
    <0.001 
    Welch t-test 
  
 IL_11 
    continuous 
    label 
    Interleukin 11 
    Interleukin 11 
    4.73 (1.39) 
    4.65 (1.53) 
    0.6424064 
    NA 
    Welch t-test 
    NA 
    TRUE 
    0.6424064 
    0.642 
    Welch t-test 
  
 IL_13 
    continuous 
    label 
    Interleukin 13 
    Interleukin 13 
    1.28 (0.01) 
    1.28 (0.01) 
    0.2577007 
    NA 
    Welch t-test 
    NA 
    TRUE 
    0.2577007 
    0.258 
    Welch t-test 
  
 IL_16 
    continuous 
    label 
    Interleukin 16 
    Interleukin 16 
    2.91 (0.67) 
    2.91 (0.65) 
    0.9601492 
    NA 
    Welch t-test 
    NA 
    TRUE 
    0.9601492 
    0.96 
    Welch t-test 
  
 IL_17E 
    continuous 
    label 
    Interleukin 17E 
    Interleukin 17E 
    4.95 (1.41) 
    4.55 (1.07) 
    0.0057222 
    NA 
    Welch t-test 
    NA 
    TRUE 
    0.0057222 
    0.00572 
    Welch t-test 
  
 IL_1alpha 
    continuous 
    label 
    Interleukin 1 alpha 
    Interleukin 1 alpha 
    -7.54 (0.39) 
    -7.48 (0.43) 
    0.3035679 
    NA 
    Welch t-test 
    NA 
    TRUE 
    0.3035679 
    0.304 
    Welch t-test 
  
 IL_3 
    continuous 
    label 
    Interleukin 3 
    Interleukin 3 
    -3.93 (0.51) 
    -3.99 (0.50) 
    0.4067009 
    NA 
    Welch t-test 
    NA 
    TRUE 
    0.4067009 
    0.407 
    Welch t-test 
  
 IL_4 
    continuous 
    label 
    Interleukin 4 
    Interleukin 4 
    1.78 (0.50) 
    1.72 (0.53) 
    0.3623877 
    NA 
    Welch t-test 
    NA 
    TRUE 
    0.3623877 
    0.362 
    Welch t-test 
  
 IL_5 
    continuous 
    label 
    Interleukin 5 
    Interleukin 5 
    0.21 (0.46) 
    0.17 (0.44) 
    0.4598690 
    NA 
    Welch t-test 
    NA 
    TRUE 
    0.4598690 
    0.46 
    Welch t-test 
  
 IL_6 
    continuous 
    label 
    Interleukin 6 
    Interleukin 6 
    -0.15 (0.51) 
    -0.14 (0.62) 
    0.9841252 
    NA 
    Welch t-test 
    NA 
    TRUE 
    0.9841252 
    0.984 
    Welch t-test 
  
 IL_6_Receptor 
    continuous 
    label 
    Interleukin 6 receptor 
    Interleukin 6 receptor 
    0.09 (0.32) 
    0.08 (0.34) 
    0.8068581 
    NA 
    Welch t-test 
    NA 
    TRUE 
    0.8068581 
    0.807 
    Welch t-test 
  
 IL_7 
    continuous 
    label 
    Interleukin 7 
    Interleukin 7 
    3.01 (0.99) 
    2.61 (1.04) 
    0.0017584 
    NA 
    Welch t-test 
    NA 
    TRUE 
    0.0017584 
    0.00176 
    Welch t-test 
  
 IL_8 
    continuous 
    label 
    Interleukin 8 
    Interleukin 8 
    1.70 (0.03) 
    1.71 (0.04) 
    0.0318468 
    NA 
    Welch t-test 
    NA 
    TRUE 
    0.0318468 
    0.0318 
    Welch t-test 
  
 IP_10_Inducible_Protein_10 
    continuous 
    label 
    Inducible protein 10 
    Inducible protein 10 
    5.69 (0.51) 
    5.85 (0.48) 
    0.0084555 
    NA 
    Welch t-test 
    NA 
    TRUE 
    0.0084555 
    0.00846 
    Welch t-test 
  
 IgA 
    continuous 
    label 
    Immunoglobulin A 
    Immunoglobulin A 
    -6.17 (0.75) 
    -5.94 (0.69) 
    0.0078162 
    NA 
    Welch t-test 
    NA 
    TRUE 
    0.0078162 
    0.00782 
    Welch t-test 
  
 Insulin 
    continuous 
    label 
    Insulin 
    Insulin 
    -1.21 (0.33) 
    -1.26 (0.36) 
    0.2895756 
    NA 
    Welch t-test 
    NA 
    TRUE 
    0.2895756 
    0.29 
    Welch t-test 
  
 Kidney_Injury_Molecule_1_KIM_1 
    continuous 
    label 
    Kidney injury molecule 1 
    Kidney injury molecule 1 
    -1.19 (0.03) 
    -1.18 (0.02) 
    0.0048740 
    NA 
    Welch t-test 
    NA 
    TRUE 
    0.0048740 
    0.00487 
    Welch t-test 
  
 LOX_1 
    continuous 
    label 
    Lectin-like oxidized LDL receptor 1 
    Lectin-like oxidized LDL receptor 1 
    1.27 (0.40) 
    1.27 (0.45) 
    0.9876103 
    NA 
    Welch t-test 
    NA 
    TRUE 
    0.9876103 
    0.988 
    Welch t-test 
  
 Leptin 
    continuous 
    label 
    Leptin 
    Leptin 
    -1.48 (0.27) 
    -1.53 (0.26) 
    0.0940108 
    NA 
    Welch t-test 
    NA 
    TRUE 
    0.0940108 
    0.094 
    Welch t-test 
  
 Lipoprotein_a 
    continuous 
    label 
    Lipoprotein(a) 
    Lipoprotein(a) 
    -4.51 (1.03) 
    -4.25 (1.16) 
    0.0629993 
    NA 
    Welch t-test 
    NA 
    TRUE 
    0.0629993 
    0.063 
    Welch t-test 
  
 MCP_1 
    continuous 
    label 
    Monocyte chemoattractant protein 1 
    Monocyte chemoattractant protein 1 
    6.48 (0.26) 
    6.52 (0.25) 
    0.1775721 
    NA 
    Welch t-test 
    NA 
    TRUE 
    0.1775721 
    0.178 
    Welch t-test 
  
 MCP_2 
    continuous 
    label 
    Monocyte chemoattractant protein 2 
    Monocyte chemoattractant protein 2 
    1.78 (0.62) 
    2.07 (0.64) 
    0.0002487 
    NA 
    Welch t-test 
    NA 
    TRUE 
    0.0002487 
    <0.001 
    Welch t-test 
  
 MIF 
    continuous 
    label 
    Macrophage migration inhibitory factor 
    Macrophage migration inhibitory factor 
    -1.93 (0.33) 
    -1.74 (0.29) 
    0.0000004 
    NA 
    Welch t-test 
    NA 
    TRUE 
    0.0000004 
    <0.001 
    Welch t-test 
  
 MIP_1alpha 
    continuous 
    label 
    Macrophage inflammatory protein 1 alpha 
    Macrophage inflammatory protein 1 alpha 
    3.94 (1.05) 
    4.24 (0.88) 
    0.0083499 
    NA 
    Welch t-test 
    NA 
    TRUE 
    0.0083499 
    0.00835 
    Welch t-test 
  
 MIP_1beta 
    continuous 
    label 
    Macrophage inflammatory protein 1 beta 
    Macrophage inflammatory protein 1 beta 
    2.79 (0.38) 
    2.87 (0.40) 
    0.0869483 
    NA 
    Welch t-test 
    NA 
    TRUE 
    0.0869483 
    0.0869 
    Welch t-test 
  
 MMP_2 
    continuous 
    label 
    Matrix metalloproteinase 2 
    Matrix metalloproteinase 2 
    2.95 (0.95) 
    2.81 (0.89) 
    0.2122963 
    NA 
    Welch t-test 
    NA 
    TRUE 
    0.2122963 
    0.212 
    Welch t-test 
  
 MMP_3 
    continuous 
    label 
    Matrix metalloproteinase 3 
    Matrix metalloproteinase 3 
    -2.49 (0.56) 
    -2.36 (0.60) 
    0.0738423 
    NA 
    Welch t-test 
    NA 
    TRUE 
    0.0738423 
    0.0738 
    Welch t-test 
  
 MMP10 
    continuous 
    label 
    Matrix metalloproteinase 10 
    Matrix metalloproteinase 10 
    -3.73 (0.40) 
    -3.42 (0.44) 
    0.0000000 
    NA 
    Welch t-test 
    NA 
    TRUE 
    0.0000000 
    <0.001 
    Welch t-test 
  
 MMP7 
    continuous 
    label 
    Matrix metalloproteinase 7 
    Matrix metalloproteinase 7 
    -4.07 (1.58) 
    -3.21 (1.28) 
    0.0000009 
    NA 
    Welch t-test 
    NA 
    TRUE 
    0.0000009 
    <0.001 
    Welch t-test 
  
 Myoglobin 
    continuous 
    label 
    Myoglobin 
    Myoglobin 
    -1.43 (0.96) 
    -1.23 (0.87) 
    0.0755465 
    NA 
    Welch t-test 
    NA 
    TRUE 
    0.0755465 
    0.0755 
    Welch t-test 
  
 NT_proBNP 
    continuous 
    label 
    N-terminal pro b-type natriuretic peptide 
    N-terminal pro b-type natriuretic peptide 
    4.46 (0.36) 
    4.71 (0.36) 
    0.0000038 
    NA 
    Welch t-test 
    NA 
    TRUE 
    0.0000038 
    <0.001 
    Welch t-test 
  
 NrCAM 
    continuous 
    label 
    Neuron-glia cell adhesion molecule 
    Neuron-glia cell adhesion molecule 
    4.38 (0.56) 
    4.33 (0.54) 
    0.5219452 
    NA 
    Welch t-test 
    NA 
    TRUE 
    0.5219452 
    0.522 
    Welch t-test 
  
 Osteopontin 
    continuous 
    label 
    Osteopontin 
    Osteopontin 
    5.16 (0.38) 
    5.31 (0.41) 
    0.0022081 
    NA 
    Welch t-test 
    NA 
    TRUE 
    0.0022081 
    0.00221 
    Welch t-test 
  
 PAI_1 
    continuous 
    label 
    Plasminogen activator inhibitor 1 
    Plasminogen activator inhibitor 1 
    -0.01 (0.38) 
    0.26 (0.44) 
    0.0000007 
    NA 
    Welch t-test 
    NA 
    TRUE 
    0.0000007 
    <0.001 
    Welch t-test 
  
 PAPP_A 
    continuous 
    label 
    Pregnancy-associated plasma protein A 
    Pregnancy-associated plasma protein A 
    -2.85 (0.14) 
    -2.85 (0.14) 
    0.9612735 
    NA 
    Welch t-test 
    NA 
    TRUE 
    0.9612735 
    0.961 
    Welch t-test 
  
 PLGF 
    continuous 
    label 
    Placental growth factor 
    Placental growth factor 
    3.87 (0.39) 
    4.01 (0.42) 
    0.0045508 
    NA 
    Welch t-test 
    NA 
    TRUE 
    0.0045508 
    0.00455 
    Welch t-test 
  
 PYY 
    continuous 
    label 
    Peptide YY 
    Peptide YY 
    3.01 (0.29) 
    3.01 (0.28) 
    0.8747602 
    NA 
    Welch t-test 
    NA 
    TRUE 
    0.8747602 
    0.875 
    Welch t-test 
  
 Pancreatic_polypeptide 
    continuous 
    label 
    Pancreatic polypeptide 
    Pancreatic polypeptide 
    -0.14 (0.67) 
    0.32 (0.74) 
    0.0000008 
    NA 
    Welch t-test 
    NA 
    TRUE 
    0.0000008 
    <0.001 
    Welch t-test 
  
 Prolactin 
    continuous 
    label 
    Prolactin 
    Prolactin 
    0.03 (0.30) 
    0.09 (0.27) 
    0.1059084 
    NA 
    Welch t-test 
    NA 
    TRUE 
    0.1059084 
    0.106 
    Welch t-test 
  
 Prostatic_Acid_Phosphatase 
    continuous 
    label 
    Prostatic acid phosphatase 
    Prostatic acid phosphatase 
    -1.69 (0.06) 
    -1.68 (0.06) 
    0.0631539 
    NA 
    Welch t-test 
    NA 
    TRUE 
    0.0631539 
    0.0632 
    Welch t-test 
  
 Protein_S 
    continuous 
    label 
    Protein S 
    Protein S 
    -2.27 (0.36) 
    -2.17 (0.37) 
    0.0181327 
    NA 
    Welch t-test 
    NA 
    TRUE 
    0.0181327 
    0.0181 
    Welch t-test 
  
 Pulmonary_and_Activation_Regulat 
    continuous 
    label 
    Pulmonary and activation-regulated chemokine 
    Pulmonary and activation-regulated chemokine 
    -1.56 (0.47) 
    -1.47 (0.35) 
    0.1259992 
    NA 
    Welch t-test 
    NA 
    TRUE 
    0.1259992 
    0.126 
    Welch t-test 
  
 RANTES 
    continuous 
    label 
    Regulated on activation, normal T cell expressed and secreted 
    Regulated on activation, normal T cell expressed and secreted 
    -6.55 (0.31) 
    -6.44 (0.31) 
    0.0044494 
    NA 
    Welch t-test 
    NA 
    TRUE 
    0.0044494 
    0.00445 
    Welch t-test 
  
 Resistin 
    continuous 
    label 
    Resistin 
    Resistin 
    -18.52 (5.42) 
    -15.74 (5.93) 
    0.0001487 
    NA 
    Welch t-test 
    NA 
    TRUE 
    0.0001487 
    <0.001 
    Welch t-test 
  
 S100b 
    continuous 
    label 
    S100 calcium-binding protein B 
    S100 calcium-binding protein B 
    1.21 (0.35) 
    1.32 (0.34) 
    0.0078991 
    NA 
    Welch t-test 
    NA 
    TRUE 
    0.0078991 
    0.0079 
    Welch t-test 
  
 SGOT 
    continuous 
    label 
    Serum glutamic-oxaloacetic transaminase 
    Serum glutamic-oxaloacetic transaminase 
    -0.44 (0.37) 
    -0.37 (0.29) 
    0.0469909 
    NA 
    Welch t-test 
    NA 
    TRUE 
    0.0469909 
    0.047 
    Welch t-test 
  
 SHBG 
    continuous 
    label 
    Sex hormone-binding globulin 
    Sex hormone-binding globulin 
    -2.54 (0.57) 
    -2.45 (0.56) 
    0.1686214 
    NA 
    Welch t-test 
    NA 
    TRUE 
    0.1686214 
    0.169 
    Welch t-test 
  
 SOD 
    continuous 
    label 
    Superoxide dismutase 
    Superoxide dismutase 
    5.31 (0.38) 
    5.39 (0.38) 
    0.0833871 
    NA 
    Welch t-test 
    NA 
    TRUE 
    0.0833871 
    0.0834 
    Welch t-test 
  
 Serum_Amyloid_P 
    continuous 
    label 
    Serum amyloid P component 
    Serum amyloid P component 
    -6.05 (0.55) 
    -5.98 (0.57) 
    0.3236618 
    NA 
    Welch t-test 
    NA 
    TRUE 
    0.3236618 
    0.324 
    Welch t-test 
  
 Sortilin 
    continuous 
    label 
    Sortilin 
    Sortilin 
    3.74 (0.86) 
    4.10 (0.83) 
    0.0005339 
    NA 
    Welch t-test 
    NA 
    TRUE 
    0.0005339 
    <0.001 
    Welch t-test 
  
 Stem_Cell_Factor 
    continuous 
    label 
    Stem cell factor 
    Stem cell factor 
    3.30 (0.36) 
    3.28 (0.34) 
    0.6843984 
    NA 
    Welch t-test 
    NA 
    TRUE 
    0.6843984 
    0.684 
    Welch t-test 
  
 TGF_alpha 
    continuous 
    label 
    Transforming growth factor alpha 
    Transforming growth factor alpha 
    9.73 (1.31) 
    9.96 (1.18) 
    0.1283139 
    NA 
    Welch t-test 
    NA 
    TRUE 
    0.1283139 
    0.128 
    Welch t-test 
  
 TIMP_1 
    continuous 
    label 
    Tissue inhibitor of metalloproteinases 1 
    Tissue inhibitor of metalloproteinases 1 
    11.55 (1.78) 
    12.11 (1.97) 
    0.0209928 
    NA 
    Welch t-test 
    NA 
    TRUE 
    0.0209928 
    0.021 
    Welch t-test 
  
 TNF_RII 
    continuous 
    label 
    Tumor necrosis factor receptor II 
    Tumor necrosis factor receptor II 
    -0.64 (0.32) 
    -0.48 (0.35) 
    0.0002205 
    NA 
    Welch t-test 
    NA 
    TRUE 
    0.0002205 
    <0.001 
    Welch t-test 
  
 TRAIL_R3 
    continuous 
    label 
    TNF-related apoptosis-inducing ligand receptor 3 
    TNF-related apoptosis-inducing ligand receptor 3 
    -0.59 (0.23) 
    -0.43 (0.23) 
    0.0000001 
    NA 
    Welch t-test 
    NA 
    TRUE 
    0.0000001 
    <0.001 
    Welch t-test 
  
 TTR_prealbumin 
    continuous 
    label 
    Transthyretin (prealbumin) 
    Transthyretin (prealbumin) 
    2.86 (0.14) 
    2.84 (0.14) 
    0.4396330 
    NA 
    Welch t-test 
    NA 
    TRUE 
    0.4396330 
    0.44 
    Welch t-test 
  
 Tamm_Horsfall_Protein_THP 
    continuous 
    label 
    Tamm-Horsfall protein 
    Tamm-Horsfall protein 
    -3.12 (0.03) 
    -3.11 (0.03) 
    0.3283328 
    NA 
    Welch t-test 
    NA 
    TRUE 
    0.3283328 
    0.328 
    Welch t-test 
  
 Thrombomodulin 
    continuous 
    label 
    Thrombomodulin 
    Thrombomodulin 
    -1.53 (0.23) 
    -1.45 (0.22) 
    0.0028089 
    NA 
    Welch t-test 
    NA 
    TRUE 
    0.0028089 
    0.00281 
    Welch t-test 
  
 Thrombopoietin 
    continuous 
    label 
    Thrombopoietin 
    Thrombopoietin 
    -0.74 (0.24) 
    -0.81 (0.25) 
    0.0630863 
    NA 
    Welch t-test 
    NA 
    TRUE 
    0.0630863 
    0.0631 
    Welch t-test 
  
 Thymus_Expressed_Chemokine_TECK 
    continuous 
    label 
    Thymus-expressed chemokine (TECK) 
    Thymus-expressed chemokine (TECK) 
    3.73 (0.77) 
    4.11 (0.76) 
    0.0000606 
    NA 
    Welch t-test 
    NA 
    TRUE 
    0.0000606 
    <0.001 
    Welch t-test 
  
 Thyroid_Stimulating_Hormone 
    continuous 
    label 
    Thyroid-stimulating hormone 
    Thyroid-stimulating hormone 
    -4.45 (0.75) 
    -4.43 (0.82) 
    0.8817515 
    NA 
    Welch t-test 
    NA 
    TRUE 
    0.8817515 
    0.882 
    Welch t-test 
  
 Thyroxine_Binding_Globulin 
    continuous 
    label 
    Thyroxine-binding globulin 
    Thyroxine-binding globulin 
    -1.51 (0.40) 
    -1.42 (0.39) 
    0.0668355 
    NA 
    Welch t-test 
    NA 
    TRUE 
    0.0668355 
    0.0668 
    Welch t-test 
  
 Tissue_Factor 
    continuous 
    label 
    Tissue factor 
    Tissue factor 
    1.16 (0.51) 
    1.18 (0.51) 
    0.7382965 
    NA 
    Welch t-test 
    NA 
    TRUE 
    0.7382965 
    0.738 
    Welch t-test 
  
 Transferrin 
    continuous 
    label 
    Transferrin 
    Transferrin 
    2.90 (0.28) 
    2.92 (0.27) 
    0.5677089 
    NA 
    Welch t-test 
    NA 
    TRUE 
    0.5677089 
    0.568 
    Welch t-test 
  
 Trefoil_Factor_3_TFF3 
    continuous 
    label 
    Trefoil factor 3 (TFF3) 
    Trefoil factor 3 (TFF3) 
    -3.90 (0.33) 
    -3.85 (0.36) 
    0.2500022 
    NA 
    Welch t-test 
    NA 
    TRUE 
    0.2500022 
    0.25 
    Welch t-test 
  
 VCAM_1 
    continuous 
    label 
    Vascular cell adhesion molecule 1 
    Vascular cell adhesion molecule 1 
    2.66 (0.30) 
    2.73 (0.37) 
    0.0887835 
    NA 
    Welch t-test 
    NA 
    TRUE 
    0.0887835 
    0.0888 
    Welch t-test 
  
 VEGF 
    continuous 
    label 
    Vascular endothelial growth factor 
    Vascular endothelial growth factor 
    17.14 (1.85) 
    16.37 (1.83) 
    0.0008075 
    NA 
    Welch t-test 
    NA 
    TRUE 
    0.0008075 
    <0.001 
    Welch t-test 
  
 Vitronectin 
    continuous 
    label 
    Vitronectin 
    Vitronectin 
    -0.28 (0.33) 
    -0.28 (0.32) 
    0.9569334 
    NA 
    Welch t-test 
    NA 
    TRUE 
    0.9569334 
    0.957 
    Welch t-test 
  
 von_Willebrand_Factor 
    continuous 
    label 
    von Willebrand factor 
    von Willebrand factor 
    -3.95 (0.37) 
    -3.86 (0.39) 
    0.0473700 
    NA 
    Welch t-test 
    NA 
    TRUE 
    0.0473700 
    0.0474 
    Welch t-test 
  
 tau 
    continuous 
    label 
    Tau protein 
    Tau protein 
    5.61 (0.49) 
    6.14 (0.55) 
    0.0000000 
    NA 
    Welch t-test 
    NA 
    TRUE 
    0.0000000 
    <0.001 
    Welch t-test 
  
 p_tau 
    continuous 
    label 
    Phosphorylated tau protein 
    Phosphorylated tau protein 
    3.94 (0.42) 
    4.30 (0.48) 
    0.0000000 
    NA 
    Welch t-test 
    NA 
    TRUE 
    0.0000000 
    <0.001 
    Welch t-test 
  
 Ab_42 
    continuous 
    label 
    Amyloid beta 42 
    Amyloid beta 42 
    12.80 (1.41) 
    11.27 (1.34) 
    0.0000000 
    NA 
    Welch t-test 
    NA 
    TRUE 
    0.0000000 
    <0.001 
    Welch t-test 
  
 age 
    continuous 
    label 
    Age 
    Age 
    72.75 (13.26) 
    71.78 (13.12) 
    0.5526369 
    NA 
    Welch t-test 
    NA 
    TRUE 
    0.5526369 
    0.553 
    Welch t-test 
  
 sex 
    categorical 
    label 
    Sex 
    Sex 
    NA 
    NA 
    0.0272353 
    NA 
    Pearson chi-squared 
    NA 
    TRUE 
    0.0272353 
    0.0272 
    Pearson chi-squared 
  
 sex 
    categorical 
    level 
    Sex 
    Female 
    157 (65%) 
    47 (52%) 
    0.0272353 
    NA 
    Pearson chi-squared 
    NA 
    FALSE 
    0.0272353 
    NA 
    NA 
  
 sex 
    categorical 
    level 
    Sex 
    Male 
    85 (35%) 
    44 (48%) 
    0.0272353 
    NA 
    Pearson chi-squared 
    NA 
    FALSE 
    0.0272353 
    NA 
    NA 
  
 Genotype 
    categorical 
    label 
    Genotype 
    Genotype 
    NA 
    NA 
    0.0005999 
    NA 
    Fisher (sim.) 
    NA 
    TRUE 
    0.0005999 
    <0.001 
    Fisher (sim.) 
  
 Genotype 
    categorical 
    level 
    Genotype 
    E2E2 
    2 (0.8%) 
    0 (0%) 
    0.0005999 
    NA 
    Fisher (sim.) 
    NA 
    FALSE 
    0.0005999 
    NA 
    NA 
  
 Genotype 
    categorical 
    level 
    Genotype 
    E2E3 
    30 (12%) 
    7 (7.7%) 
    0.0005999 
    NA 
    Fisher (sim.) 
    NA 
    FALSE 
    0.0005999 
    NA 
    NA 
  
 Genotype 
    categorical 
    level 
    Genotype 
    E2E4 
    7 (2.9%) 
    1 (1.1%) 
    0.0005999 
    NA 
    Fisher (sim.) 
    NA 
    FALSE 
    0.0005999 
    NA 
    NA 
  
 Genotype 
    categorical 
    level 
    Genotype 
    E3E3 
    133 (55%) 
    34 (37%) 
    0.0005999 
    NA 
    Fisher (sim.) 
    NA 
    FALSE 
    0.0005999 
    NA 
    NA 
  
 Genotype 
    categorical 
    level 
    Genotype 
    E3E4 
    65 (27%) 
    41 (45%) 
    0.0005999 
    NA 
    Fisher (sim.) 
    NA 
    FALSE 
    0.0005999 
    NA 
    NA 
  
 Genotype 
    categorical 
    level 
    Genotype 
    E4E4 
    5 (2.1%) 
    8 (8.8%) 
    0.0005999 
    NA 
    Fisher (sim.) 
    NA 
    FALSE 
    0.0005999 
    NA 
    NA 
  
 ACE_CD143_Angiotensin_Converti 
    continuous 
    label 
    Angiotensin-converting enzyme 
    Angiotensin-converting enzyme 
    1.32 (0.56) 
    1.31 (0.53) 
    0.8846265 
    NA 
    Welch t-test 
    NA 
    TRUE 
    0.8846265 
    0.885 
    Welch t-test 
  
 ACTH_Adrenocorticotropic_Hormon 
    continuous 
    label 
    Adrenocorticotropic hormone 
    Adrenocorticotropic hormone 
    -1.55 (0.27) 
    -1.51 (0.29) 
    0.3228133 
    NA 
    Welch t-test 
    NA 
    TRUE 
    0.3228133 
    0.323 
    Welch t-test 
  
 AXL 
    continuous 
    label 
    AXL receptor tyrosine kinase 
    AXL receptor tyrosine kinase 
    0.28 (0.46) 
    0.34 (0.41) 
    0.2384182 
    NA 
    Welch t-test 
    NA 
    TRUE 
    0.2384182 
    0.238 
    Welch t-test 
  
 Adiponectin 
    continuous 
    label 
    Adiponectin 
    Adiponectin 
    -5.26 (0.65) 
    -5.10 (0.69) 
    0.0538971 
    NA 
    Welch t-test 
    NA 
    TRUE 
    0.0538971 
    0.0539 
    Welch t-test 
  
 Alpha_1_Antichymotrypsin 
    continuous 
    label 
    Alpha-1-antichymotrypsin 
    Alpha-1-antichymotrypsin 
    1.32 (0.36) 
    1.44 (0.37) 
    0.0096393 
    NA 
    Welch t-test 
    NA 
    TRUE 
    0.0096393 
    0.00964 
    Welch t-test 
  
 Alpha_1_Antitrypsin 
    continuous 
    label 
    Alpha-1-antitrypsin 
    Alpha-1-antitrypsin 
    -13.33 (1.51) 
    -12.62 (1.52) 
    0.0001841 
    NA 
    Welch t-test 
    NA 
    TRUE 
    0.0001841 
    <0.001 
    Welch t-test 
  
 Alpha_1_Microglobulin 
    continuous 
    label 
    Alpha-1-microglobulin 
    Alpha-1-microglobulin 
    -2.99 (0.48) 
    -2.82 (0.45) 
    0.0030400 
    NA 
    Welch t-test 
    NA 
    TRUE 
    0.0030400 
    0.00304 
    Welch t-test 
  
 Alpha_2_Macroglobulin 
    continuous 
    label 
    Alpha-2-macroglobulin 
    Alpha-2-macroglobulin 
    -162.49 (41.36) 
    -151.41 (38.78) 
    0.0237020 
    NA 
    Welch t-test 
    NA 
    TRUE 
    0.0237020 
    0.0237 
    Welch t-test 
  
 Angiopoietin_2_ANG_2 
    continuous 
    label 
    Angiopoietin-2 
    Angiopoietin-2 
    0.65 (0.33) 
    0.70 (0.34) 
    0.2243927 
    NA 
    Welch t-test 
    NA 
    TRUE 
    0.2243927 
    0.224 
    Welch t-test 
  
 Angiotensinogen 
    continuous 
    label 
    Angiotensinogen 
    Angiotensinogen 
    2.31 (0.25) 
    2.38 (0.25) 
    0.0363220 
    NA 
    Welch t-test 
    NA 
    TRUE 
    0.0363220 
    0.0363 
    Welch t-test 
  
 Apolipoprotein_A_IV 
    continuous 
    label 
    Apolipoprotein A-IV 
    Apolipoprotein A-IV 
    -1.86 (0.39) 
    -1.84 (0.37) 
    0.6196039 
    NA 
    Welch t-test 
    NA 
    TRUE 
    0.6196039 
    0.62 
    Welch t-test 
  
 Apolipoprotein_A1 
    continuous 
    label 
    Apolipoprotein A-1 
    Apolipoprotein A-1 
    -7.48 (0.43) 
    -7.50 (0.44) 
    0.6901145 
    NA 
    Welch t-test 
    NA 
    TRUE 
    0.6901145 
    0.69 
    Welch t-test 
  
 Apolipoprotein_A2 
    continuous 
    label 
    Apolipoprotein A-2 
    Apolipoprotein A-2 
    -0.66 (0.50) 
    -0.61 (0.48) 
    0.3909281 
    NA 
    Welch t-test 
    NA 
    TRUE 
    0.3909281 
    0.391 
    Welch t-test 
  
 Apolipoprotein_B 
    continuous 
    label 
    Apolipoprotein B 
    Apolipoprotein B 
    -5.71 (1.40) 
    -5.27 (1.55) 
    0.0183210 
    NA 
    Welch t-test 
    NA 
    TRUE 
    0.0183210 
    0.0183 
    Welch t-test 
  
 Apolipoprotein_CI 
    continuous 
    label 
    Apolipoprotein C-I 
    Apolipoprotein C-I 
    -1.60 (0.41) 
    -1.58 (0.45) 
    0.8186647 
    NA 
    Welch t-test 
    NA 
    TRUE 
    0.8186647 
    0.819 
    Welch t-test 
  
 Apolipoprotein_CIII 
    continuous 
    label 
    Apolipoprotein C-III 
    Apolipoprotein C-III 
    -2.53 (0.44) 
    -2.42 (0.44) 
    0.0350373 
    NA 
    Welch t-test 
    NA 
    TRUE 
    0.0350373 
    0.035 
    Welch t-test 
  
 Apolipoprotein_D 
    continuous 
    label 
    Apolipoprotein D 
    Apolipoprotein D 
    1.39 (0.33) 
    1.54 (0.38) 
    0.0015555 
    NA 
    Welch t-test 
    NA 
    TRUE 
    0.0015555 
    0.00156 
    Welch t-test 
  
 Apolipoprotein_E 
    continuous 
    label 
    Apolipoprotein E 
    Apolipoprotein E 
    2.79 (0.77) 
    2.78 (0.87) 
    0.8668217 
    NA 
    Welch t-test 
    NA 
    TRUE 
    0.8668217 
    0.867 
    Welch t-test 
  
 Apolipoprotein_H 
    continuous 
    label 
    Apolipoprotein H 
    Apolipoprotein H 
    -0.35 (0.38) 
    -0.23 (0.38) 
    0.0106232 
    NA 
    Welch t-test 
    NA 
    TRUE 
    0.0106232 
    0.0106 
    Welch t-test 
  
 B_Lymphocyte_Chemoattractant_BL 
    continuous 
    label 
    B-lymphocyte chemoattractant 
    B-lymphocyte chemoattractant 
    1.92 (0.57) 
    2.16 (0.56) 
    0.0007177 
    NA 
    Welch t-test 
    NA 
    TRUE 
    0.0007177 
    <0.001 
    Welch t-test 
  
 BMP_6 
    continuous 
    label 
    Bone morphogenetic protein 6 
    Bone morphogenetic protein 6 
    -1.89 (0.29) 
    -1.92 (0.33) 
    0.5218752 
    NA 
    Welch t-test 
    NA 
    TRUE 
    0.5218752 
    0.522 
    Welch t-test 
  
 Beta_2_Microglobulin 
    continuous 
    label 
    Beta-2-microglobulin 
    Beta-2-microglobulin 
    0.16 (0.29) 
    0.19 (0.31) 
    0.4233981 
    NA 
    Welch t-test 
    NA 
    TRUE 
    0.4233981 
    0.423 
    Welch t-test 
  
 Betacellulin 
    continuous 
    label 
    Betacellulin 
    Betacellulin 
    51.63 (10.91) 
    50.62 (10.60) 
    0.4399492 
    NA 
    Welch t-test 
    NA 
    TRUE 
    0.4399492 
    0.44 
    Welch t-test 
  
 C_Reactive_Protein 
    continuous 
    label 
    C-reactive protein 
    C-reactive protein 
    -5.87 (1.22) 
    -5.97 (1.14) 
    0.4843525 
    NA 
    Welch t-test 
    NA 
    TRUE 
    0.4843525 
    0.484 
    Welch t-test 
  
 CD40 
    continuous 
    label 
    CD40 
    CD40 
    -1.26 (0.21) 
    -1.28 (0.24) 
    0.5003297 
    NA 
    Welch t-test 
    NA 
    TRUE 
    0.5003297 
    0.5 
    Welch t-test 
  
 CD5L 
    continuous 
    label 
    CD5L 
    CD5L 
    -0.10 (0.44) 
    0.04 (0.49) 
    0.0247260 
    NA 
    Welch t-test 
    NA 
    TRUE 
    0.0247260 
    0.0247 
    Welch t-test 
  
 Calbindin 
    continuous 
    label 
    Calbindin 
    Calbindin 
    21.99 (3.90) 
    22.93 (4.85) 
    0.1011017 
    NA 
    Welch t-test 
    NA 
    TRUE 
    0.1011017 
    0.101 
    Welch t-test 
  
 Calcitonin 
    continuous 
    label 
    Calcitonin 
    Calcitonin 
    1.68 (0.85) 
    1.71 (0.94) 
    0.7808643 
    NA 
    Welch t-test 
    NA 
    TRUE 
    0.7808643 
    0.781 
    Welch t-test 
  
 CgA 
    continuous 
    label 
    Chromogranin A 
    Chromogranin A 
    329.78 (82.65) 
    333.17 (81.12) 
    0.7351867 
    NA 
    Welch t-test 
    NA 
    TRUE 
    0.7351867 
    0.735 
    Welch t-test 
  
 Clusterin_Apo_J 
    continuous 
    label 
    Clusterin (ApoJ) 
    Clusterin (ApoJ) 
    2.85 (0.29) 
    2.95 (0.33) 
    0.0116372 
    NA 
    Welch t-test 
    NA 
    TRUE 
    0.0116372 
    0.0116 
    Welch t-test 
  
 Complement_3 
    continuous 
    label 
    Complement component 3 
    Complement component 3 
    -15.95 (2.45) 
    -14.92 (2.43) 
    0.0007632 
    NA 
    Welch t-test 
    NA 
    TRUE 
    0.0007632 
    <0.001 
    Welch t-test 
  
 Complement_Factor_H 
    continuous 
    label 
    Complement factor H 
    Complement factor H 
    3.48 (1.26) 
    3.62 (1.22) 
    0.3580892 
    NA 
    Welch t-test 
    NA 
    TRUE 
    0.3580892 
    0.358 
    Welch t-test 
  
 Connective_Tissue_Growth_Factor 
    continuous 
    label 
    Connective tissue growth factor 
    Connective tissue growth factor 
    0.76 (0.21) 
    0.79 (0.20) 
    0.2752610 
    NA 
    Welch t-test 
    NA 
    TRUE 
    0.2752610 
    0.275 
    Welch t-test 
  
 Cortisol 
    continuous 
    label 
    Cortisol 
    Cortisol 
    11.22 (3.73) 
    12.93 (4.34) 
    0.0011179 
    NA 
    Welch t-test 
    NA 
    TRUE 
    0.0011179 
    0.00112 
    Welch t-test 
  
 Creatine_Kinase_MB 
    continuous 
    label 
    Creatine kinase-MB 
    Creatine kinase-MB 
    -1.66 (0.10) 
    -1.70 (0.08) 
    0.0001039 
    NA 
    Welch t-test 
    NA 
    TRUE 
    0.0001039 
    <0.001 
    Welch t-test 
  
 Cystatin_C 
    continuous 
    label 
    Cystatin C 
    Cystatin C 
    8.62 (0.40) 
    8.48 (0.40) 
    0.0055073 
    NA 
    Welch t-test 
    NA 
    TRUE 
    0.0055073 
    0.00551 
    Welch t-test 
  
 EGF_R 
    continuous 
    label 
    Epidermal growth factor receptor 
    Epidermal growth factor receptor 
    -0.71 (0.24) 
    -0.68 (0.22) 
    0.4379144 
    NA 
    Welch t-test 
    NA 
    TRUE 
    0.4379144 
    0.438 
    Welch t-test 
  
 EN_RAGE 
    continuous 
    label 
    EN-RAGE (extracellular newly identified RAGE-binding protein) 
    EN-RAGE (extracellular newly identified RAGE-binding protein) 
    -3.62 (0.90) 
    -3.65 (0.88) 
    0.7659387 
    NA 
    Welch t-test 
    NA 
    TRUE 
    0.7659387 
    0.766 
    Welch t-test 
  
 ENA_78 
    continuous 
    label 
    ENA-78 (epithelial-derived neutrophil-activating protein 78) 
    ENA-78 (epithelial-derived neutrophil-activating protein 78) 
    -1.37 (0.01) 
    -1.37 (0.01) 
    0.9254390 
    NA 
    Welch t-test 
    NA 
    TRUE 
    0.9254390 
    0.925 
    Welch t-test 
  
 Eotaxin_3 
    continuous 
    label 
    Eotaxin-3 
    Eotaxin-3 
    55.36 (15.98) 
    63.75 (15.86) 
    0.0000303 
    NA 
    Welch t-test 
    NA 
    TRUE 
    0.0000303 
    <0.001 
    Welch t-test 
  
 FAS 
    continuous 
    label 
    Fas (tumor necrosis factor receptor superfamily member 6) 
    Fas (tumor necrosis factor receptor superfamily member 6) 
    -0.58 (0.28) 
    -0.40 (0.31) 
    0.0000019 
    NA 
    Welch t-test 
    NA 
    TRUE 
    0.0000019 
    <0.001 
    Welch t-test 
  
 FSH_Follicle_Stimulation_Hormon 
    continuous 
    label 
    Follicle-stimulating hormone 
    Follicle-stimulating hormone 
    -1.12 (0.39) 
    -1.15 (0.43) 
    0.6164374 
    NA 
    Welch t-test 
    NA 
    TRUE 
    0.6164374 
    0.616 
    Welch t-test 
  
 Fas_Ligand 
    continuous 
    label 
    Fas ligand 
    Fas ligand 
    2.79 (1.05) 
    3.22 (1.12) 
    0.0015514 
    NA 
    Welch t-test 
    NA 
    TRUE 
    0.0015514 
    0.00155 
    Welch t-test 
  
 Fatty_Acid_Binding_Protein 
    continuous 
    label 
    Fatty acid-binding protein 
    Fatty acid-binding protein 
    1.24 (0.73) 
    1.59 (0.86) 
    0.0007710 
    NA 
    Welch t-test 
    NA 
    TRUE 
    0.0007710 
    <0.001 
    Welch t-test 
  
 Ferritin 
    continuous 
    label 
    Ferritin 
    Ferritin 
    2.70 (0.76) 
    2.90 (0.83) 
    0.0426440 
    NA 
    Welch t-test 
    NA 
    TRUE 
    0.0426440 
    0.0426 
    Welch t-test 
  
 Fetuin_A 
    continuous 
    label 
    Fetuin-A 
    Fetuin-A 
    1.32 (0.40) 
    1.44 (0.34) 
    0.0314522 
    NA 
    Welch t-test 
    NA 
    TRUE 
    0.0314522 
    0.0315 
    Welch t-test 
  
 Fibrinogen 
    continuous 
    label 
    Fibrinogen 
    Fibrinogen 
    -7.45 (0.56) 
    -7.12 (0.57) 
    0.0000075 
    NA 
    Welch t-test 
    NA 
    TRUE 
    0.0000075 
    <0.001 
    Welch t-test 
  
 GRO_alpha 
    continuous 
    label 
    Growth-regulated alpha protein 
    Growth-regulated alpha protein 
    1.37 (0.04) 
    1.40 (0.04) 
    0.0000000 
    NA 
    Welch t-test 
    NA 
    TRUE 
    0.0000000 
    <0.001 
    Welch t-test 
  
 Gamma_Interferon_induced_Monokin 
    continuous 
    label 
    Gamma interferon-induced monokine 
    Gamma interferon-induced monokine 
    2.77 (0.11) 
    2.83 (0.10) 
    0.0000059 
    NA 
    Welch t-test 
    NA 
    TRUE 
    0.0000059 
    <0.001 
    Welch t-test 
  
 Glutathione_S_Transferase_alpha 
    continuous 
    label 
    Glutathione S-transferase alpha 
    Glutathione S-transferase alpha 
    0.95 (0.17) 
    0.96 (0.12) 
    0.5459600 
    NA 
    Welch t-test 
    NA 
    TRUE 
    0.5459600 
    0.546 
    Welch t-test 
  
 HB_EGF 
    continuous 
    label 
    Heparin-binding epidermal growth factor 
    Heparin-binding epidermal growth factor 
    6.70 (1.47) 
    7.20 (1.49) 
    0.0061319 
    NA 
    Welch t-test 
    NA 
    TRUE 
    0.0061319 
    0.00613 
    Welch t-test 
  
 HCC_4 
    continuous 
    label 
    HCC-4 (hemofiltrate CC chemokine-4) 
    HCC-4 (hemofiltrate CC chemokine-4) 
    -3.55 (0.36) 
    -3.40 (0.34) 
    0.0005695 
    NA 
    Welch t-test 
    NA 
    TRUE 
    0.0005695 
    <0.001 
    Welch t-test 
  
 Hepatocyte_Growth_Factor_HGF 
    continuous 
    label 
    Hepatocyte growth factor 
    Hepatocyte growth factor 
    0.17 (0.29) 
    0.27 (0.29) 
    0.0051215 
    NA 
    Welch t-test 
    NA 
    TRUE 
    0.0051215 
    0.00512 
    Welch t-test 
  
 I_309 
    continuous 
    label 
    I-309 (TCA-3) 
    I-309 (TCA-3) 
    2.92 (0.36) 
    3.02 (0.39) 
    0.0337660 
    NA 
    Welch t-test 
    NA 
    TRUE 
    0.0337660 
    0.0338 
    Welch t-test 
  
 ICAM_1 
    continuous 
    label 
    Intercellular adhesion molecule 1 
    Intercellular adhesion molecule 1 
    -0.60 (0.32) 
    -0.56 (0.36) 
    0.3368872 
    NA 
    Welch t-test 
    NA 
    TRUE 
    0.3368872 
    0.337 
    Welch t-test 
  
 IGF_BP_2 
    continuous 
    label 
    Insulin-like growth factor-binding protein 2 
    Insulin-like growth factor-binding protein 2 
    5.28 (0.20) 
    5.38 (0.22) 
    0.0001243 
    NA 
    Welch t-test 
    NA 
    TRUE 
    0.0001243 
    <0.001 
    Welch t-test 
  
 IL_11 
    continuous 
    label 
    Interleukin 11 
    Interleukin 11 
    4.73 (1.39) 
    4.65 (1.53) 
    0.6424064 
    NA 
    Welch t-test 
    NA 
    TRUE 
    0.6424064 
    0.642 
    Welch t-test 
  
 IL_13 
    continuous 
    label 
    Interleukin 13 
    Interleukin 13 
    1.28 (0.01) 
    1.28 (0.01) 
    0.2577007 
    NA 
    Welch t-test 
    NA 
    TRUE 
    0.2577007 
    0.258 
    Welch t-test 
  
 IL_16 
    continuous 
    label 
    Interleukin 16 
    Interleukin 16 
    2.91 (0.67) 
    2.91 (0.65) 
    0.9601492 
    NA 
    Welch t-test 
    NA 
    TRUE 
    0.9601492 
    0.96 
    Welch t-test 
  
 IL_17E 
    continuous 
    label 
    Interleukin 17E 
    Interleukin 17E 
    4.95 (1.41) 
    4.55 (1.07) 
    0.0057222 
    NA 
    Welch t-test 
    NA 
    TRUE 
    0.0057222 
    0.00572 
    Welch t-test 
  
 IL_1alpha 
    continuous 
    label 
    Interleukin 1 alpha 
    Interleukin 1 alpha 
    -7.54 (0.39) 
    -7.48 (0.43) 
    0.3035679 
    NA 
    Welch t-test 
    NA 
    TRUE 
    0.3035679 
    0.304 
    Welch t-test 
  
 IL_3 
    continuous 
    label 
    Interleukin 3 
    Interleukin 3 
    -3.93 (0.51) 
    -3.99 (0.50) 
    0.4067009 
    NA 
    Welch t-test 
    NA 
    TRUE 
    0.4067009 
    0.407 
    Welch t-test 
  
 IL_4 
    continuous 
    label 
    Interleukin 4 
    Interleukin 4 
    1.78 (0.50) 
    1.72 (0.53) 
    0.3623877 
    NA 
    Welch t-test 
    NA 
    TRUE 
    0.3623877 
    0.362 
    Welch t-test 
  
 IL_5 
    continuous 
    label 
    Interleukin 5 
    Interleukin 5 
    0.21 (0.46) 
    0.17 (0.44) 
    0.4598690 
    NA 
    Welch t-test 
    NA 
    TRUE 
    0.4598690 
    0.46 
    Welch t-test 
  
 IL_6 
    continuous 
    label 
    Interleukin 6 
    Interleukin 6 
    -0.15 (0.51) 
    -0.14 (0.62) 
    0.9841252 
    NA 
    Welch t-test 
    NA 
    TRUE 
    0.9841252 
    0.984 
    Welch t-test 
  
 IL_6_Receptor 
    continuous 
    label 
    Interleukin 6 receptor 
    Interleukin 6 receptor 
    0.09 (0.32) 
    0.08 (0.34) 
    0.8068581 
    NA 
    Welch t-test 
    NA 
    TRUE 
    0.8068581 
    0.807 
    Welch t-test 
  
 IL_7 
    continuous 
    label 
    Interleukin 7 
    Interleukin 7 
    3.01 (0.99) 
    2.61 (1.04) 
    0.0017584 
    NA 
    Welch t-test 
    NA 
    TRUE 
    0.0017584 
    0.00176 
    Welch t-test 
  
 IL_8 
    continuous 
    label 
    Interleukin 8 
    Interleukin 8 
    1.70 (0.03) 
    1.71 (0.04) 
    0.0318468 
    NA 
    Welch t-test 
    NA 
    TRUE 
    0.0318468 
    0.0318 
    Welch t-test 
  
 IP_10_Inducible_Protein_10 
    continuous 
    label 
    Inducible protein 10 
    Inducible protein 10 
    5.69 (0.51) 
    5.85 (0.48) 
    0.0084555 
    NA 
    Welch t-test 
    NA 
    TRUE 
    0.0084555 
    0.00846 
    Welch t-test 
  
 IgA 
    continuous 
    label 
    Immunoglobulin A 
    Immunoglobulin A 
    -6.17 (0.75) 
    -5.94 (0.69) 
    0.0078162 
    NA 
    Welch t-test 
    NA 
    TRUE 
    0.0078162 
    0.00782 
    Welch t-test 
  
 Insulin 
    continuous 
    label 
    Insulin 
    Insulin 
    -1.21 (0.33) 
    -1.26 (0.36) 
    0.2895756 
    NA 
    Welch t-test 
    NA 
    TRUE 
    0.2895756 
    0.29 
    Welch t-test 
  
 Kidney_Injury_Molecule_1_KIM_1 
    continuous 
    label 
    Kidney injury molecule 1 
    Kidney injury molecule 1 
    -1.19 (0.03) 
    -1.18 (0.02) 
    0.0048740 
    NA 
    Welch t-test 
    NA 
    TRUE 
    0.0048740 
    0.00487 
    Welch t-test 
  
 LOX_1 
    continuous 
    label 
    Lectin-like oxidized LDL receptor 1 
    Lectin-like oxidized LDL receptor 1 
    1.27 (0.40) 
    1.27 (0.45) 
    0.9876103 
    NA 
    Welch t-test 
    NA 
    TRUE 
    0.9876103 
    0.988 
    Welch t-test 
  
 Leptin 
    continuous 
    label 
    Leptin 
    Leptin 
    -1.48 (0.27) 
    -1.53 (0.26) 
    0.0940108 
    NA 
    Welch t-test 
    NA 
    TRUE 
    0.0940108 
    0.094 
    Welch t-test 
  
 Lipoprotein_a 
    continuous 
    label 
    Lipoprotein(a) 
    Lipoprotein(a) 
    -4.51 (1.03) 
    -4.25 (1.16) 
    0.0629993 
    NA 
    Welch t-test 
    NA 
    TRUE 
    0.0629993 
    0.063 
    Welch t-test 
  
 MCP_1 
    continuous 
    label 
    Monocyte chemoattractant protein 1 
    Monocyte chemoattractant protein 1 
    6.48 (0.26) 
    6.52 (0.25) 
    0.1775721 
    NA 
    Welch t-test 
    NA 
    TRUE 
    0.1775721 
    0.178 
    Welch t-test 
  
 MCP_2 
    continuous 
    label 
    Monocyte chemoattractant protein 2 
    Monocyte chemoattractant protein 2 
    1.78 (0.62) 
    2.07 (0.64) 
    0.0002487 
    NA 
    Welch t-test 
    NA 
    TRUE 
    0.0002487 
    <0.001 
    Welch t-test 
  
 MIF 
    continuous 
    label 
    Macrophage migration inhibitory factor 
    Macrophage migration inhibitory factor 
    -1.93 (0.33) 
    -1.74 (0.29) 
    0.0000004 
    NA 
    Welch t-test 
    NA 
    TRUE 
    0.0000004 
    <0.001 
    Welch t-test 
  
 MIP_1alpha 
    continuous 
    label 
    Macrophage inflammatory protein 1 alpha 
    Macrophage inflammatory protein 1 alpha 
    3.94 (1.05) 
    4.24 (0.88) 
    0.0083499 
    NA 
    Welch t-test 
    NA 
    TRUE 
    0.0083499 
    0.00835 
    Welch t-test 
  
 MIP_1beta 
    continuous 
    label 
    Macrophage inflammatory protein 1 beta 
    Macrophage inflammatory protein 1 beta 
    2.79 (0.38) 
    2.87 (0.40) 
    0.0869483 
    NA 
    Welch t-test 
    NA 
    TRUE 
    0.0869483 
    0.0869 
    Welch t-test 
  
 MMP_2 
    continuous 
    label 
    Matrix metalloproteinase 2 
    Matrix metalloproteinase 2 
    2.95 (0.95) 
    2.81 (0.89) 
    0.2122963 
    NA 
    Welch t-test 
    NA 
    TRUE 
    0.2122963 
    0.212 
    Welch t-test 
  
 MMP_3 
    continuous 
    label 
    Matrix metalloproteinase 3 
    Matrix metalloproteinase 3 
    -2.49 (0.56) 
    -2.36 (0.60) 
    0.0738423 
    NA 
    Welch t-test 
    NA 
    TRUE 
    0.0738423 
    0.0738 
    Welch t-test 
  
 MMP10 
    continuous 
    label 
    Matrix metalloproteinase 10 
    Matrix metalloproteinase 10 
    -3.73 (0.40) 
    -3.42 (0.44) 
    0.0000000 
    NA 
    Welch t-test 
    NA 
    TRUE 
    0.0000000 
    <0.001 
    Welch t-test 
  
 MMP7 
    continuous 
    label 
    Matrix metalloproteinase 7 
    Matrix metalloproteinase 7 
    -4.07 (1.58) 
    -3.21 (1.28) 
    0.0000009 
    NA 
    Welch t-test 
    NA 
    TRUE 
    0.0000009 
    <0.001 
    Welch t-test 
  
 Myoglobin 
    continuous 
    label 
    Myoglobin 
    Myoglobin 
    -1.43 (0.96) 
    -1.23 (0.87) 
    0.0755465 
    NA 
    Welch t-test 
    NA 
    TRUE 
    0.0755465 
    0.0755 
    Welch t-test 
  
 NT_proBNP 
    continuous 
    label 
    N-terminal pro b-type natriuretic peptide 
    N-terminal pro b-type natriuretic peptide 
    4.46 (0.36) 
    4.71 (0.36) 
    0.0000038 
    NA 
    Welch t-test 
    NA 
    TRUE 
    0.0000038 
    <0.001 
    Welch t-test 
  
 NrCAM 
    continuous 
    label 
    Neuron-glia cell adhesion molecule 
    Neuron-glia cell adhesion molecule 
    4.38 (0.56) 
    4.33 (0.54) 
    0.5219452 
    NA 
    Welch t-test 
    NA 
    TRUE 
    0.5219452 
    0.522 
    Welch t-test 
  
 Osteopontin 
    continuous 
    label 
    Osteopontin 
    Osteopontin 
    5.16 (0.38) 
    5.31 (0.41) 
    0.0022081 
    NA 
    Welch t-test 
    NA 
    TRUE 
    0.0022081 
    0.00221 
    Welch t-test 
  
 PAI_1 
    continuous 
    label 
    Plasminogen activator inhibitor 1 
    Plasminogen activator inhibitor 1 
    -0.01 (0.38) 
    0.26 (0.44) 
    0.0000007 
    NA 
    Welch t-test 
    NA 
    TRUE 
    0.0000007 
    <0.001 
    Welch t-test 
  
 PAPP_A 
    continuous 
    label 
    Pregnancy-associated plasma protein A 
    Pregnancy-associated plasma protein A 
    -2.85 (0.14) 
    -2.85 (0.14) 
    0.9612735 
    NA 
    Welch t-test 
    NA 
    TRUE 
    0.9612735 
    0.961 
    Welch t-test 
  
 PLGF 
    continuous 
    label 
    Placental growth factor 
    Placental growth factor 
    3.87 (0.39) 
    4.01 (0.42) 
    0.0045508 
    NA 
    Welch t-test 
    NA 
    TRUE 
    0.0045508 
    0.00455 
    Welch t-test 
  
 PYY 
    continuous 
    label 
    Peptide YY 
    Peptide YY 
    3.01 (0.29) 
    3.01 (0.28) 
    0.8747602 
    NA 
    Welch t-test 
    NA 
    TRUE 
    0.8747602 
    0.875 
    Welch t-test 
  
 Pancreatic_polypeptide 
    continuous 
    label 
    Pancreatic polypeptide 
    Pancreatic polypeptide 
    -0.14 (0.67) 
    0.32 (0.74) 
    0.0000008 
    NA 
    Welch t-test 
    NA 
    TRUE 
    0.0000008 
    <0.001 
    Welch t-test 
  
 Prolactin 
    continuous 
    label 
    Prolactin 
    Prolactin 
    0.03 (0.30) 
    0.09 (0.27) 
    0.1059084 
    NA 
    Welch t-test 
    NA 
    TRUE 
    0.1059084 
    0.106 
    Welch t-test 
  
 Prostatic_Acid_Phosphatase 
    continuous 
    label 
    Prostatic acid phosphatase 
    Prostatic acid phosphatase 
    -1.69 (0.06) 
    -1.68 (0.06) 
    0.0631539 
    NA 
    Welch t-test 
    NA 
    TRUE 
    0.0631539 
    0.0632 
    Welch t-test 
  
 Protein_S 
    continuous 
    label 
    Protein S 
    Protein S 
    -2.27 (0.36) 
    -2.17 (0.37) 
    0.0181327 
    NA 
    Welch t-test 
    NA 
    TRUE 
    0.0181327 
    0.0181 
    Welch t-test 
  
 Pulmonary_and_Activation_Regulat 
    continuous 
    label 
    Pulmonary and activation-regulated chemokine 
    Pulmonary and activation-regulated chemokine 
    -1.56 (0.47) 
    -1.47 (0.35) 
    0.1259992 
    NA 
    Welch t-test 
    NA 
    TRUE 
    0.1259992 
    0.126 
    Welch t-test 
  
 RANTES 
    continuous 
    label 
    Regulated on activation, normal T cell expressed and secreted 
    Regulated on activation, normal T cell expressed and secreted 
    -6.55 (0.31) 
    -6.44 (0.31) 
    0.0044494 
    NA 
    Welch t-test 
    NA 
    TRUE 
    0.0044494 
    0.00445 
    Welch t-test 
  
 Resistin 
    continuous 
    label 
    Resistin 
    Resistin 
    -18.52 (5.42) 
    -15.74 (5.93) 
    0.0001487 
    NA 
    Welch t-test 
    NA 
    TRUE 
    0.0001487 
    <0.001 
    Welch t-test 
  
 S100b 
    continuous 
    label 
    S100 calcium-binding protein B 
    S100 calcium-binding protein B 
    1.21 (0.35) 
    1.32 (0.34) 
    0.0078991 
    NA 
    Welch t-test 
    NA 
    TRUE 
    0.0078991 
    0.0079 
    Welch t-test 
  
 SGOT 
    continuous 
    label 
    Serum glutamic-oxaloacetic transaminase 
    Serum glutamic-oxaloacetic transaminase 
    -0.44 (0.37) 
    -0.37 (0.29) 
    0.0469909 
    NA 
    Welch t-test 
    NA 
    TRUE 
    0.0469909 
    0.047 
    Welch t-test 
  
 SHBG 
    continuous 
    label 
    Sex hormone-binding globulin 
    Sex hormone-binding globulin 
    -2.54 (0.57) 
    -2.45 (0.56) 
    0.1686214 
    NA 
    Welch t-test 
    NA 
    TRUE 
    0.1686214 
    0.169 
    Welch t-test 
  
 SOD 
    continuous 
    label 
    Superoxide dismutase 
    Superoxide dismutase 
    5.31 (0.38) 
    5.39 (0.38) 
    0.0833871 
    NA 
    Welch t-test 
    NA 
    TRUE 
    0.0833871 
    0.0834 
    Welch t-test 
  
 Serum_Amyloid_P 
    continuous 
    label 
    Serum amyloid P component 
    Serum amyloid P component 
    -6.05 (0.55) 
    -5.98 (0.57) 
    0.3236618 
    NA 
    Welch t-test 
    NA 
    TRUE 
    0.3236618 
    0.324 
    Welch t-test 
  
 Sortilin 
    continuous 
    label 
    Sortilin 
    Sortilin 
    3.74 (0.86) 
    4.10 (0.83) 
    0.0005339 
    NA 
    Welch t-test 
    NA 
    TRUE 
    0.0005339 
    <0.001 
    Welch t-test 
  
 Stem_Cell_Factor 
    continuous 
    label 
    Stem cell factor 
    Stem cell factor 
    3.30 (0.36) 
    3.28 (0.34) 
    0.6843984 
    NA 
    Welch t-test 
    NA 
    TRUE 
    0.6843984 
    0.684 
    Welch t-test 
  
 TGF_alpha 
    continuous 
    label 
    Transforming growth factor alpha 
    Transforming growth factor alpha 
    9.73 (1.31) 
    9.96 (1.18) 
    0.1283139 
    NA 
    Welch t-test 
    NA 
    TRUE 
    0.1283139 
    0.128 
    Welch t-test 
  
 TIMP_1 
    continuous 
    label 
    Tissue inhibitor of metalloproteinases 1 
    Tissue inhibitor of metalloproteinases 1 
    11.55 (1.78) 
    12.11 (1.97) 
    0.0209928 
    NA 
    Welch t-test 
    NA 
    TRUE 
    0.0209928 
    0.021 
    Welch t-test 
  
 TNF_RII 
    continuous 
    label 
    Tumor necrosis factor receptor II 
    Tumor necrosis factor receptor II 
    -0.64 (0.32) 
    -0.48 (0.35) 
    0.0002205 
    NA 
    Welch t-test 
    NA 
    TRUE 
    0.0002205 
    <0.001 
    Welch t-test 
  
 TRAIL_R3 
    continuous 
    label 
    TNF-related apoptosis-inducing ligand receptor 3 
    TNF-related apoptosis-inducing ligand receptor 3 
    -0.59 (0.23) 
    -0.43 (0.23) 
    0.0000001 
    NA 
    Welch t-test 
    NA 
    TRUE 
    0.0000001 
    <0.001 
    Welch t-test 
  
 TTR_prealbumin 
    continuous 
    label 
    Transthyretin (prealbumin) 
    Transthyretin (prealbumin) 
    2.86 (0.14) 
    2.84 (0.14) 
    0.4396330 
    NA 
    Welch t-test 
    NA 
    TRUE 
    0.4396330 
    0.44 
    Welch t-test 
  
 Tamm_Horsfall_Protein_THP 
    continuous 
    label 
    Tamm-Horsfall protein 
    Tamm-Horsfall protein 
    -3.12 (0.03) 
    -3.11 (0.03) 
    0.3283328 
    NA 
    Welch t-test 
    NA 
    TRUE 
    0.3283328 
    0.328 
    Welch t-test 
  
 Thrombomodulin 
    continuous 
    label 
    Thrombomodulin 
    Thrombomodulin 
    -1.53 (0.23) 
    -1.45 (0.22) 
    0.0028089 
    NA 
    Welch t-test 
    NA 
    TRUE 
    0.0028089 
    0.00281 
    Welch t-test 
  
 Thrombopoietin 
    continuous 
    label 
    Thrombopoietin 
    Thrombopoietin 
    -0.74 (0.24) 
    -0.81 (0.25) 
    0.0630863 
    NA 
    Welch t-test 
    NA 
    TRUE 
    0.0630863 
    0.0631 
    Welch t-test 
  
 Thymus_Expressed_Chemokine_TECK 
    continuous 
    label 
    Thymus-expressed chemokine (TECK) 
    Thymus-expressed chemokine (TECK) 
    3.73 (0.77) 
    4.11 (0.76) 
    0.0000606 
    NA 
    Welch t-test 
    NA 
    TRUE 
    0.0000606 
    <0.001 
    Welch t-test 
  
 Thyroid_Stimulating_Hormone 
    continuous 
    label 
    Thyroid-stimulating hormone 
    Thyroid-stimulating hormone 
    -4.45 (0.75) 
    -4.43 (0.82) 
    0.8817515 
    NA 
    Welch t-test 
    NA 
    TRUE 
    0.8817515 
    0.882 
    Welch t-test 
  
 Thyroxine_Binding_Globulin 
    continuous 
    label 
    Thyroxine-binding globulin 
    Thyroxine-binding globulin 
    -1.51 (0.40) 
    -1.42 (0.39) 
    0.0668355 
    NA 
    Welch t-test 
    NA 
    TRUE 
    0.0668355 
    0.0668 
    Welch t-test 
  
 Tissue_Factor 
    continuous 
    label 
    Tissue factor 
    Tissue factor 
    1.16 (0.51) 
    1.18 (0.51) 
    0.7382965 
    NA 
    Welch t-test 
    NA 
    TRUE 
    0.7382965 
    0.738 
    Welch t-test 
  
 Transferrin 
    continuous 
    label 
    Transferrin 
    Transferrin 
    2.90 (0.28) 
    2.92 (0.27) 
    0.5677089 
    NA 
    Welch t-test 
    NA 
    TRUE 
    0.5677089 
    0.568 
    Welch t-test 
  
 Trefoil_Factor_3_TFF3 
    continuous 
    label 
    Trefoil factor 3 (TFF3) 
    Trefoil factor 3 (TFF3) 
    -3.90 (0.33) 
    -3.85 (0.36) 
    0.2500022 
    NA 
    Welch t-test 
    NA 
    TRUE 
    0.2500022 
    0.25 
    Welch t-test 
  
 VCAM_1 
    continuous 
    label 
    Vascular cell adhesion molecule 1 
    Vascular cell adhesion molecule 1 
    2.66 (0.30) 
    2.73 (0.37) 
    0.0887835 
    NA 
    Welch t-test 
    NA 
    TRUE 
    0.0887835 
    0.0888 
    Welch t-test 
  
 VEGF 
    continuous 
    label 
    Vascular endothelial growth factor 
    Vascular endothelial growth factor 
    17.14 (1.85) 
    16.37 (1.83) 
    0.0008075 
    NA 
    Welch t-test 
    NA 
    TRUE 
    0.0008075 
    <0.001 
    Welch t-test 
  
 Vitronectin 
    continuous 
    label 
    Vitronectin 
    Vitronectin 
    -0.28 (0.33) 
    -0.28 (0.32) 
    0.9569334 
    NA 
    Welch t-test 
    NA 
    TRUE 
    0.9569334 
    0.957 
    Welch t-test 
  
 von_Willebrand_Factor 
    continuous 
    label 
    von Willebrand factor 
    von Willebrand factor 
    -3.95 (0.37) 
    -3.86 (0.39) 
    0.0473700 
    NA 
    Welch t-test 
    NA 
    TRUE 
    0.0473700 
    0.0474 
    Welch t-test 
  
 tau 
    continuous 
    label 
    Tau protein 
    Tau protein 
    5.61 (0.49) 
    6.14 (0.55) 
    0.0000000 
    NA 
    Welch t-test 
    NA 
    TRUE 
    0.0000000 
    <0.001 
    Welch t-test 
  
 p_tau 
    continuous 
    label 
    Phosphorylated tau protein 
    Phosphorylated tau protein 
    3.94 (0.42) 
    4.30 (0.48) 
    0.0000000 
    NA 
    Welch t-test 
    NA 
    TRUE 
    0.0000000 
    <0.001 
    Welch t-test 
  
 Ab_42 
    continuous 
    label 
    Amyloid beta 42 
    Amyloid beta 42 
    12.80 (1.41) 
    11.27 (1.34) 
    0.0000000 
    NA 
    Welch t-test 
    NA 
    TRUE 
    0.0000000 
    <0.001 
    Welch t-test 
  
 age 
    continuous 
    label 
    Age 
    Age 
    72.75 (13.26) 
    71.78 (13.12) 
    0.5526369 
    NA 
    Welch t-test 
    NA 
    TRUE 
    0.5526369 
    0.553 
    Welch t-test 
  
 sex 
    categorical 
    label 
    Sex 
    Sex 
    NA 
    NA 
    0.0272353 
    NA 
    Pearson chi-squared 
    NA 
    TRUE 
    0.0272353 
    0.0272 
    Pearson chi-squared 
  
 sex 
    categorical 
    level 
    Sex 
    Female 
    157 (65%) 
    47 (52%) 
    0.0272353 
    NA 
    Pearson chi-squared 
    NA 
    FALSE 
    0.0272353 
    NA 
    NA 
  
 sex 
    categorical 
    level 
    Sex 
    Male 
    85 (35%) 
    44 (48%) 
    0.0272353 
    NA 
    Pearson chi-squared 
    NA 
    FALSE 
    0.0272353 
    NA 
    NA 
  
 Genotype 
    categorical 
    label 
    Genotype 
    Genotype 
    NA 
    NA 
    0.0005999 
    NA 
    Fisher (sim.) 
    NA 
    TRUE 
    0.0005999 
    <0.001 
    Fisher (sim.) 
  
 Genotype 
    categorical 
    level 
    Genotype 
    E2E2 
    2 (0.8%) 
    0 (0%) 
    0.0005999 
    NA 
    Fisher (sim.) 
    NA 
    FALSE 
    0.0005999 
    NA 
    NA 
  
 Genotype 
    categorical 
    level 
    Genotype 
    E2E3 
    30 (12%) 
    7 (7.7%) 
    0.0005999 
    NA 
    Fisher (sim.) 
    NA 
    FALSE 
    0.0005999 
    NA 
    NA 
  
 Genotype 
    categorical 
    level 
    Genotype 
    E2E4 
    7 (2.9%) 
    1 (1.1%) 
    0.0005999 
    NA 
    Fisher (sim.) 
    NA 
    FALSE 
    0.0005999 
    NA 
    NA 
  
 Genotype 
    categorical 
    level 
    Genotype 
    E3E3 
    133 (55%) 
    34 (37%) 
    0.0005999 
    NA 
    Fisher (sim.) 
    NA 
    FALSE 
    0.0005999 
    NA 
    NA 
  
 Genotype 
    categorical 
    level 
    Genotype 
    E3E4 
    65 (27%) 
    41 (45%) 
    0.0005999 
    NA 
    Fisher (sim.) 
    NA 
    FALSE 
    0.0005999 
    NA 
    NA 
  
 Genotype 
    categorical 
    level 
    Genotype 
    E4E4 
    5 (2.1%) 
    8 (8.8%) 
    0.0005999 
    NA 
    Fisher (sim.) 
    NA 
    FALSE 
    0.0005999 
    NA 
    NA 
  
 ACE_CD143_Angiotensin_Converti 
    continuous 
    label 
    Angiotensin-converting enzyme 
    Angiotensin-converting enzyme 
    1.32 (0.56) 
    1.31 (0.53) 
    0.8846265 
    NA 
    Welch t-test 
    NA 
    TRUE 
    0.8846265 
    0.885 
    Welch t-test 
  
 ACTH_Adrenocorticotropic_Hormon 
    continuous 
    label 
    Adrenocorticotropic hormone 
    Adrenocorticotropic hormone 
    -1.55 (0.27) 
    -1.51 (0.29) 
    0.3228133 
    NA 
    Welch t-test 
    NA 
    TRUE 
    0.3228133 
    0.323 
    Welch t-test 
  
 AXL 
    continuous 
    label 
    AXL receptor tyrosine kinase 
    AXL receptor tyrosine kinase 
    0.28 (0.46) 
    0.34 (0.41) 
    0.2384182 
    NA 
    Welch t-test 
    NA 
    TRUE 
    0.2384182 
    0.238 
    Welch t-test 
  
 Adiponectin 
    continuous 
    label 
    Adiponectin 
    Adiponectin 
    -5.26 (0.65) 
    -5.10 (0.69) 
    0.0538971 
    NA 
    Welch t-test 
    NA 
    TRUE 
    0.0538971 
    0.0539 
    Welch t-test 
  
 Alpha_1_Antichymotrypsin 
    continuous 
    label 
    Alpha-1-antichymotrypsin 
    Alpha-1-antichymotrypsin 
    1.32 (0.36) 
    1.44 (0.37) 
    0.0096393 
    NA 
    Welch t-test 
    NA 
    TRUE 
    0.0096393 
    0.00964 
    Welch t-test 
  
 Alpha_1_Antitrypsin 
    continuous 
    label 
    Alpha-1-antitrypsin 
    Alpha-1-antitrypsin 
    -13.33 (1.51) 
    -12.62 (1.52) 
    0.0001841 
    NA 
    Welch t-test 
    NA 
    TRUE 
    0.0001841 
    <0.001 
    Welch t-test 
  
 Alpha_1_Microglobulin 
    continuous 
    label 
    Alpha-1-microglobulin 
    Alpha-1-microglobulin 
    -2.99 (0.48) 
    -2.82 (0.45) 
    0.0030400 
    NA 
    Welch t-test 
    NA 
    TRUE 
    0.0030400 
    0.00304 
    Welch t-test 
  
 Alpha_2_Macroglobulin 
    continuous 
    label 
    Alpha-2-macroglobulin 
    Alpha-2-macroglobulin 
    -162.49 (41.36) 
    -151.41 (38.78) 
    0.0237020 
    NA 
    Welch t-test 
    NA 
    TRUE 
    0.0237020 
    0.0237 
    Welch t-test 
  
 Angiopoietin_2_ANG_2 
    continuous 
    label 
    Angiopoietin-2 
    Angiopoietin-2 
    0.65 (0.33) 
    0.70 (0.34) 
    0.2243927 
    NA 
    Welch t-test 
    NA 
    TRUE 
    0.2243927 
    0.224 
    Welch t-test 
  
 Angiotensinogen 
    continuous 
    label 
    Angiotensinogen 
    Angiotensinogen 
    2.31 (0.25) 
    2.38 (0.25) 
    0.0363220 
    NA 
    Welch t-test 
    NA 
    TRUE 
    0.0363220 
    0.0363 
    Welch t-test 
  
 Apolipoprotein_A_IV 
    continuous 
    label 
    Apolipoprotein A-IV 
    Apolipoprotein A-IV 
    -1.86 (0.39) 
    -1.84 (0.37) 
    0.6196039 
    NA 
    Welch t-test 
    NA 
    TRUE 
    0.6196039 
    0.62 
    Welch t-test 
  
 Apolipoprotein_A1 
    continuous 
    label 
    Apolipoprotein A-1 
    Apolipoprotein A-1 
    -7.48 (0.43) 
    -7.50 (0.44) 
    0.6901145 
    NA 
    Welch t-test 
    NA 
    TRUE 
    0.6901145 
    0.69 
    Welch t-test 
  
 Apolipoprotein_A2 
    continuous 
    label 
    Apolipoprotein A-2 
    Apolipoprotein A-2 
    -0.66 (0.50) 
    -0.61 (0.48) 
    0.3909281 
    NA 
    Welch t-test 
    NA 
    TRUE 
    0.3909281 
    0.391 
    Welch t-test 
  
 Apolipoprotein_B 
    continuous 
    label 
    Apolipoprotein B 
    Apolipoprotein B 
    -5.71 (1.40) 
    -5.27 (1.55) 
    0.0183210 
    NA 
    Welch t-test 
    NA 
    TRUE 
    0.0183210 
    0.0183 
    Welch t-test 
  
 Apolipoprotein_CI 
    continuous 
    label 
    Apolipoprotein C-I 
    Apolipoprotein C-I 
    -1.60 (0.41) 
    -1.58 (0.45) 
    0.8186647 
    NA 
    Welch t-test 
    NA 
    TRUE 
    0.8186647 
    0.819 
    Welch t-test 
  
 Apolipoprotein_CIII 
    continuous 
    label 
    Apolipoprotein C-III 
    Apolipoprotein C-III 
    -2.53 (0.44) 
    -2.42 (0.44) 
    0.0350373 
    NA 
    Welch t-test 
    NA 
    TRUE 
    0.0350373 
    0.035 
    Welch t-test 
  
 Apolipoprotein_D 
    continuous 
    label 
    Apolipoprotein D 
    Apolipoprotein D 
    1.39 (0.33) 
    1.54 (0.38) 
    0.0015555 
    NA 
    Welch t-test 
    NA 
    TRUE 
    0.0015555 
    0.00156 
    Welch t-test 
  
 Apolipoprotein_E 
    continuous 
    label 
    Apolipoprotein E 
    Apolipoprotein E 
    2.79 (0.77) 
    2.78 (0.87) 
    0.8668217 
    NA 
    Welch t-test 
    NA 
    TRUE 
    0.8668217 
    0.867 
    Welch t-test 
  
 Apolipoprotein_H 
    continuous 
    label 
    Apolipoprotein H 
    Apolipoprotein H 
    -0.35 (0.38) 
    -0.23 (0.38) 
    0.0106232 
    NA 
    Welch t-test 
    NA 
    TRUE 
    0.0106232 
    0.0106 
    Welch t-test 
  
 B_Lymphocyte_Chemoattractant_BL 
    continuous 
    label 
    B-lymphocyte chemoattractant 
    B-lymphocyte chemoattractant 
    1.92 (0.57) 
    2.16 (0.56) 
    0.0007177 
    NA 
    Welch t-test 
    NA 
    TRUE 
    0.0007177 
    <0.001 
    Welch t-test 
  
 BMP_6 
    continuous 
    label 
    Bone morphogenetic protein 6 
    Bone morphogenetic protein 6 
    -1.89 (0.29) 
    -1.92 (0.33) 
    0.5218752 
    NA 
    Welch t-test 
    NA 
    TRUE 
    0.5218752 
    0.522 
    Welch t-test 
  
 Beta_2_Microglobulin 
    continuous 
    label 
    Beta-2-microglobulin 
    Beta-2-microglobulin 
    0.16 (0.29) 
    0.19 (0.31) 
    0.4233981 
    NA 
    Welch t-test 
    NA 
    TRUE 
    0.4233981 
    0.423 
    Welch t-test 
  
 Betacellulin 
    continuous 
    label 
    Betacellulin 
    Betacellulin 
    51.63 (10.91) 
    50.62 (10.60) 
    0.4399492 
    NA 
    Welch t-test 
    NA 
    TRUE 
    0.4399492 
    0.44 
    Welch t-test 
  
 C_Reactive_Protein 
    continuous 
    label 
    C-reactive protein 
    C-reactive protein 
    -5.87 (1.22) 
    -5.97 (1.14) 
    0.4843525 
    NA 
    Welch t-test 
    NA 
    TRUE 
    0.4843525 
    0.484 
    Welch t-test 
  
 CD40 
    continuous 
    label 
    CD40 
    CD40 
    -1.26 (0.21) 
    -1.28 (0.24) 
    0.5003297 
    NA 
    Welch t-test 
    NA 
    TRUE 
    0.5003297 
    0.5 
    Welch t-test 
  
 CD5L 
    continuous 
    label 
    CD5L 
    CD5L 
    -0.10 (0.44) 
    0.04 (0.49) 
    0.0247260 
    NA 
    Welch t-test 
    NA 
    TRUE 
    0.0247260 
    0.0247 
    Welch t-test 
  
 Calbindin 
    continuous 
    label 
    Calbindin 
    Calbindin 
    21.99 (3.90) 
    22.93 (4.85) 
    0.1011017 
    NA 
    Welch t-test 
    NA 
    TRUE 
    0.1011017 
    0.101 
    Welch t-test 
  
 Calcitonin 
    continuous 
    label 
    Calcitonin 
    Calcitonin 
    1.68 (0.85) 
    1.71 (0.94) 
    0.7808643 
    NA 
    Welch t-test 
    NA 
    TRUE 
    0.7808643 
    0.781 
    Welch t-test 
  
 CgA 
    continuous 
    label 
    Chromogranin A 
    Chromogranin A 
    329.78 (82.65) 
    333.17 (81.12) 
    0.7351867 
    NA 
    Welch t-test 
    NA 
    TRUE 
    0.7351867 
    0.735 
    Welch t-test 
  
 Clusterin_Apo_J 
    continuous 
    label 
    Clusterin (ApoJ) 
    Clusterin (ApoJ) 
    2.85 (0.29) 
    2.95 (0.33) 
    0.0116372 
    NA 
    Welch t-test 
    NA 
    TRUE 
    0.0116372 
    0.0116 
    Welch t-test 
  
 Complement_3 
    continuous 
    label 
    Complement component 3 
    Complement component 3 
    -15.95 (2.45) 
    -14.92 (2.43) 
    0.0007632 
    NA 
    Welch t-test 
    NA 
    TRUE 
    0.0007632 
    <0.001 
    Welch t-test 
  
 Complement_Factor_H 
    continuous 
    label 
    Complement factor H 
    Complement factor H 
    3.48 (1.26) 
    3.62 (1.22) 
    0.3580892 
    NA 
    Welch t-test 
    NA 
    TRUE 
    0.3580892 
    0.358 
    Welch t-test 
  
 Connective_Tissue_Growth_Factor 
    continuous 
    label 
    Connective tissue growth factor 
    Connective tissue growth factor 
    0.76 (0.21) 
    0.79 (0.20) 
    0.2752610 
    NA 
    Welch t-test 
    NA 
    TRUE 
    0.2752610 
    0.275 
    Welch t-test 
  
 Cortisol 
    continuous 
    label 
    Cortisol 
    Cortisol 
    11.22 (3.73) 
    12.93 (4.34) 
    0.0011179 
    NA 
    Welch t-test 
    NA 
    TRUE 
    0.0011179 
    0.00112 
    Welch t-test 
  
 Creatine_Kinase_MB 
    continuous 
    label 
    Creatine kinase-MB 
    Creatine kinase-MB 
    -1.66 (0.10) 
    -1.70 (0.08) 
    0.0001039 
    NA 
    Welch t-test 
    NA 
    TRUE 
    0.0001039 
    <0.001 
    Welch t-test 
  
 Cystatin_C 
    continuous 
    label 
    Cystatin C 
    Cystatin C 
    8.62 (0.40) 
    8.48 (0.40) 
    0.0055073 
    NA 
    Welch t-test 
    NA 
    TRUE 
    0.0055073 
    0.00551 
    Welch t-test 
  
 EGF_R 
    continuous 
    label 
    Epidermal growth factor receptor 
    Epidermal growth factor receptor 
    -0.71 (0.24) 
    -0.68 (0.22) 
    0.4379144 
    NA 
    Welch t-test 
    NA 
    TRUE 
    0.4379144 
    0.438 
    Welch t-test 
  
 EN_RAGE 
    continuous 
    label 
    EN-RAGE (extracellular newly identified RAGE-binding protein) 
    EN-RAGE (extracellular newly identified RAGE-binding protein) 
    -3.62 (0.90) 
    -3.65 (0.88) 
    0.7659387 
    NA 
    Welch t-test 
    NA 
    TRUE 
    0.7659387 
    0.766 
    Welch t-test 
  
 ENA_78 
    continuous 
    label 
    ENA-78 (epithelial-derived neutrophil-activating protein 78) 
    ENA-78 (epithelial-derived neutrophil-activating protein 78) 
    -1.37 (0.01) 
    -1.37 (0.01) 
    0.9254390 
    NA 
    Welch t-test 
    NA 
    TRUE 
    0.9254390 
    0.925 
    Welch t-test 
  
 Eotaxin_3 
    continuous 
    label 
    Eotaxin-3 
    Eotaxin-3 
    55.36 (15.98) 
    63.75 (15.86) 
    0.0000303 
    NA 
    Welch t-test 
    NA 
    TRUE 
    0.0000303 
    <0.001 
    Welch t-test 
  
 FAS 
    continuous 
    label 
    Fas (tumor necrosis factor receptor superfamily member 6) 
    Fas (tumor necrosis factor receptor superfamily member 6) 
    -0.58 (0.28) 
    -0.40 (0.31) 
    0.0000019 
    NA 
    Welch t-test 
    NA 
    TRUE 
    0.0000019 
    <0.001 
    Welch t-test 
  
 FSH_Follicle_Stimulation_Hormon 
    continuous 
    label 
    Follicle-stimulating hormone 
    Follicle-stimulating hormone 
    -1.12 (0.39) 
    -1.15 (0.43) 
    0.6164374 
    NA 
    Welch t-test 
    NA 
    TRUE 
    0.6164374 
    0.616 
    Welch t-test 
  
 Fas_Ligand 
    continuous 
    label 
    Fas ligand 
    Fas ligand 
    2.79 (1.05) 
    3.22 (1.12) 
    0.0015514 
    NA 
    Welch t-test 
    NA 
    TRUE 
    0.0015514 
    0.00155 
    Welch t-test 
  
 Fatty_Acid_Binding_Protein 
    continuous 
    label 
    Fatty acid-binding protein 
    Fatty acid-binding protein 
    1.24 (0.73) 
    1.59 (0.86) 
    0.0007710 
    NA 
    Welch t-test 
    NA 
    TRUE 
    0.0007710 
    <0.001 
    Welch t-test 
  
 Ferritin 
    continuous 
    label 
    Ferritin 
    Ferritin 
    2.70 (0.76) 
    2.90 (0.83) 
    0.0426440 
    NA 
    Welch t-test 
    NA 
    TRUE 
    0.0426440 
    0.0426 
    Welch t-test 
  
 Fetuin_A 
    continuous 
    label 
    Fetuin-A 
    Fetuin-A 
    1.32 (0.40) 
    1.44 (0.34) 
    0.0314522 
    NA 
    Welch t-test 
    NA 
    TRUE 
    0.0314522 
    0.0315 
    Welch t-test 
  
 Fibrinogen 
    continuous 
    label 
    Fibrinogen 
    Fibrinogen 
    -7.45 (0.56) 
    -7.12 (0.57) 
    0.0000075 
    NA 
    Welch t-test 
    NA 
    TRUE 
    0.0000075 
    <0.001 
    Welch t-test 
  
 GRO_alpha 
    continuous 
    label 
    Growth-regulated alpha protein 
    Growth-regulated alpha protein 
    1.37 (0.04) 
    1.40 (0.04) 
    0.0000000 
    NA 
    Welch t-test 
    NA 
    TRUE 
    0.0000000 
    <0.001 
    Welch t-test 
  
 Gamma_Interferon_induced_Monokin 
    continuous 
    label 
    Gamma interferon-induced monokine 
    Gamma interferon-induced monokine 
    2.77 (0.11) 
    2.83 (0.10) 
    0.0000059 
    NA 
    Welch t-test 
    NA 
    TRUE 
    0.0000059 
    <0.001 
    Welch t-test 
  
 Glutathione_S_Transferase_alpha 
    continuous 
    label 
    Glutathione S-transferase alpha 
    Glutathione S-transferase alpha 
    0.95 (0.17) 
    0.96 (0.12) 
    0.5459600 
    NA 
    Welch t-test 
    NA 
    TRUE 
    0.5459600 
    0.546 
    Welch t-test 
  
 HB_EGF 
    continuous 
    label 
    Heparin-binding epidermal growth factor 
    Heparin-binding epidermal growth factor 
    6.70 (1.47) 
    7.20 (1.49) 
    0.0061319 
    NA 
    Welch t-test 
    NA 
    TRUE 
    0.0061319 
    0.00613 
    Welch t-test 
  
 HCC_4 
    continuous 
    label 
    HCC-4 (hemofiltrate CC chemokine-4) 
    HCC-4 (hemofiltrate CC chemokine-4) 
    -3.55 (0.36) 
    -3.40 (0.34) 
    0.0005695 
    NA 
    Welch t-test 
    NA 
    TRUE 
    0.0005695 
    <0.001 
    Welch t-test 
  
 Hepatocyte_Growth_Factor_HGF 
    continuous 
    label 
    Hepatocyte growth factor 
    Hepatocyte growth factor 
    0.17 (0.29) 
    0.27 (0.29) 
    0.0051215 
    NA 
    Welch t-test 
    NA 
    TRUE 
    0.0051215 
    0.00512 
    Welch t-test 
  
 I_309 
    continuous 
    label 
    I-309 (TCA-3) 
    I-309 (TCA-3) 
    2.92 (0.36) 
    3.02 (0.39) 
    0.0337660 
    NA 
    Welch t-test 
    NA 
    TRUE 
    0.0337660 
    0.0338 
    Welch t-test 
  
 ICAM_1 
    continuous 
    label 
    Intercellular adhesion molecule 1 
    Intercellular adhesion molecule 1 
    -0.60 (0.32) 
    -0.56 (0.36) 
    0.3368872 
    NA 
    Welch t-test 
    NA 
    TRUE 
    0.3368872 
    0.337 
    Welch t-test 
  
 IGF_BP_2 
    continuous 
    label 
    Insulin-like growth factor-binding protein 2 
    Insulin-like growth factor-binding protein 2 
    5.28 (0.20) 
    5.38 (0.22) 
    0.0001243 
    NA 
    Welch t-test 
    NA 
    TRUE 
    0.0001243 
    <0.001 
    Welch t-test 
  
 IL_11 
    continuous 
    label 
    Interleukin 11 
    Interleukin 11 
    4.73 (1.39) 
    4.65 (1.53) 
    0.6424064 
    NA 
    Welch t-test 
    NA 
    TRUE 
    0.6424064 
    0.642 
    Welch t-test 
  
 IL_13 
    continuous 
    label 
    Interleukin 13 
    Interleukin 13 
    1.28 (0.01) 
    1.28 (0.01) 
    0.2577007 
    NA 
    Welch t-test 
    NA 
    TRUE 
    0.2577007 
    0.258 
    Welch t-test 
  
 IL_16 
    continuous 
    label 
    Interleukin 16 
    Interleukin 16 
    2.91 (0.67) 
    2.91 (0.65) 
    0.9601492 
    NA 
    Welch t-test 
    NA 
    TRUE 
    0.9601492 
    0.96 
    Welch t-test 
  
 IL_17E 
    continuous 
    label 
    Interleukin 17E 
    Interleukin 17E 
    4.95 (1.41) 
    4.55 (1.07) 
    0.0057222 
    NA 
    Welch t-test 
    NA 
    TRUE 
    0.0057222 
    0.00572 
    Welch t-test 
  
 IL_1alpha 
    continuous 
    label 
    Interleukin 1 alpha 
    Interleukin 1 alpha 
    -7.54 (0.39) 
    -7.48 (0.43) 
    0.3035679 
    NA 
    Welch t-test 
    NA 
    TRUE 
    0.3035679 
    0.304 
    Welch t-test 
  
 IL_3 
    continuous 
    label 
    Interleukin 3 
    Interleukin 3 
    -3.93 (0.51) 
    -3.99 (0.50) 
    0.4067009 
    NA 
    Welch t-test 
    NA 
    TRUE 
    0.4067009 
    0.407 
    Welch t-test 
  
 IL_4 
    continuous 
    label 
    Interleukin 4 
    Interleukin 4 
    1.78 (0.50) 
    1.72 (0.53) 
    0.3623877 
    NA 
    Welch t-test 
    NA 
    TRUE 
    0.3623877 
    0.362 
    Welch t-test 
  
 IL_5 
    continuous 
    label 
    Interleukin 5 
    Interleukin 5 
    0.21 (0.46) 
    0.17 (0.44) 
    0.4598690 
    NA 
    Welch t-test 
    NA 
    TRUE 
    0.4598690 
    0.46 
    Welch t-test 
  
 IL_6 
    continuous 
    label 
    Interleukin 6 
    Interleukin 6 
    -0.15 (0.51) 
    -0.14 (0.62) 
    0.9841252 
    NA 
    Welch t-test 
    NA 
    TRUE 
    0.9841252 
    0.984 
    Welch t-test 
  
 IL_6_Receptor 
    continuous 
    label 
    Interleukin 6 receptor 
    Interleukin 6 receptor 
    0.09 (0.32) 
    0.08 (0.34) 
    0.8068581 
    NA 
    Welch t-test 
    NA 
    TRUE 
    0.8068581 
    0.807 
    Welch t-test 
  
 IL_7 
    continuous 
    label 
    Interleukin 7 
    Interleukin 7 
    3.01 (0.99) 
    2.61 (1.04) 
    0.0017584 
    NA 
    Welch t-test 
    NA 
    TRUE 
    0.0017584 
    0.00176 
    Welch t-test 
  
 IL_8 
    continuous 
    label 
    Interleukin 8 
    Interleukin 8 
    1.70 (0.03) 
    1.71 (0.04) 
    0.0318468 
    NA 
    Welch t-test 
    NA 
    TRUE 
    0.0318468 
    0.0318 
    Welch t-test 
  
 IP_10_Inducible_Protein_10 
    continuous 
    label 
    Inducible protein 10 
    Inducible protein 10 
    5.69 (0.51) 
    5.85 (0.48) 
    0.0084555 
    NA 
    Welch t-test 
    NA 
    TRUE 
    0.0084555 
    0.00846 
    Welch t-test 
  
 IgA 
    continuous 
    label 
    Immunoglobulin A 
    Immunoglobulin A 
    -6.17 (0.75) 
    -5.94 (0.69) 
    0.0078162 
    NA 
    Welch t-test 
    NA 
    TRUE 
    0.0078162 
    0.00782 
    Welch t-test 
  
 Insulin 
    continuous 
    label 
    Insulin 
    Insulin 
    -1.21 (0.33) 
    -1.26 (0.36) 
    0.2895756 
    NA 
    Welch t-test 
    NA 
    TRUE 
    0.2895756 
    0.29 
    Welch t-test 
  
 Kidney_Injury_Molecule_1_KIM_1 
    continuous 
    label 
    Kidney injury molecule 1 
    Kidney injury molecule 1 
    -1.19 (0.03) 
    -1.18 (0.02) 
    0.0048740 
    NA 
    Welch t-test 
    NA 
    TRUE 
    0.0048740 
    0.00487 
    Welch t-test 
  
 LOX_1 
    continuous 
    label 
    Lectin-like oxidized LDL receptor 1 
    Lectin-like oxidized LDL receptor 1 
    1.27 (0.40) 
    1.27 (0.45) 
    0.9876103 
    NA 
    Welch t-test 
    NA 
    TRUE 
    0.9876103 
    0.988 
    Welch t-test 
  
 Leptin 
    continuous 
    label 
    Leptin 
    Leptin 
    -1.48 (0.27) 
    -1.53 (0.26) 
    0.0940108 
    NA 
    Welch t-test 
    NA 
    TRUE 
    0.0940108 
    0.094 
    Welch t-test 
  
 Lipoprotein_a 
    continuous 
    label 
    Lipoprotein(a) 
    Lipoprotein(a) 
    -4.51 (1.03) 
    -4.25 (1.16) 
    0.0629993 
    NA 
    Welch t-test 
    NA 
    TRUE 
    0.0629993 
    0.063 
    Welch t-test 
  
 MCP_1 
    continuous 
    label 
    Monocyte chemoattractant protein 1 
    Monocyte chemoattractant protein 1 
    6.48 (0.26) 
    6.52 (0.25) 
    0.1775721 
    NA 
    Welch t-test 
    NA 
    TRUE 
    0.1775721 
    0.178 
    Welch t-test 
  
 MCP_2 
    continuous 
    label 
    Monocyte chemoattractant protein 2 
    Monocyte chemoattractant protein 2 
    1.78 (0.62) 
    2.07 (0.64) 
    0.0002487 
    NA 
    Welch t-test 
    NA 
    TRUE 
    0.0002487 
    <0.001 
    Welch t-test 
  
 MIF 
    continuous 
    label 
    Macrophage migration inhibitory factor 
    Macrophage migration inhibitory factor 
    -1.93 (0.33) 
    -1.74 (0.29) 
    0.0000004 
    NA 
    Welch t-test 
    NA 
    TRUE 
    0.0000004 
    <0.001 
    Welch t-test 
  
 MIP_1alpha 
    continuous 
    label 
    Macrophage inflammatory protein 1 alpha 
    Macrophage inflammatory protein 1 alpha 
    3.94 (1.05) 
    4.24 (0.88) 
    0.0083499 
    NA 
    Welch t-test 
    NA 
    TRUE 
    0.0083499 
    0.00835 
    Welch t-test 
  
 MIP_1beta 
    continuous 
    label 
    Macrophage inflammatory protein 1 beta 
    Macrophage inflammatory protein 1 beta 
    2.79 (0.38) 
    2.87 (0.40) 
    0.0869483 
    NA 
    Welch t-test 
    NA 
    TRUE 
    0.0869483 
    0.0869 
    Welch t-test 
  
 MMP_2 
    continuous 
    label 
    Matrix metalloproteinase 2 
    Matrix metalloproteinase 2 
    2.95 (0.95) 
    2.81 (0.89) 
    0.2122963 
    NA 
    Welch t-test 
    NA 
    TRUE 
    0.2122963 
    0.212 
    Welch t-test 
  
 MMP_3 
    continuous 
    label 
    Matrix metalloproteinase 3 
    Matrix metalloproteinase 3 
    -2.49 (0.56) 
    -2.36 (0.60) 
    0.0738423 
    NA 
    Welch t-test 
    NA 
    TRUE 
    0.0738423 
    0.0738 
    Welch t-test 
  
 MMP10 
    continuous 
    label 
    Matrix metalloproteinase 10 
    Matrix metalloproteinase 10 
    -3.73 (0.40) 
    -3.42 (0.44) 
    0.0000000 
    NA 
    Welch t-test 
    NA 
    TRUE 
    0.0000000 
    <0.001 
    Welch t-test 
  
 MMP7 
    continuous 
    label 
    Matrix metalloproteinase 7 
    Matrix metalloproteinase 7 
    -4.07 (1.58) 
    -3.21 (1.28) 
    0.0000009 
    NA 
    Welch t-test 
    NA 
    TRUE 
    0.0000009 
    <0.001 
    Welch t-test 
  
 Myoglobin 
    continuous 
    label 
    Myoglobin 
    Myoglobin 
    -1.43 (0.96) 
    -1.23 (0.87) 
    0.0755465 
    NA 
    Welch t-test 
    NA 
    TRUE 
    0.0755465 
    0.0755 
    Welch t-test 
  
 NT_proBNP 
    continuous 
    label 
    N-terminal pro b-type natriuretic peptide 
    N-terminal pro b-type natriuretic peptide 
    4.46 (0.36) 
    4.71 (0.36) 
    0.0000038 
    NA 
    Welch t-test 
    NA 
    TRUE 
    0.0000038 
    <0.001 
    Welch t-test 
  
 NrCAM 
    continuous 
    label 
    Neuron-glia cell adhesion molecule 
    Neuron-glia cell adhesion molecule 
    4.38 (0.56) 
    4.33 (0.54) 
    0.5219452 
    NA 
    Welch t-test 
    NA 
    TRUE 
    0.5219452 
    0.522 
    Welch t-test 
  
 Osteopontin 
    continuous 
    label 
    Osteopontin 
    Osteopontin 
    5.16 (0.38) 
    5.31 (0.41) 
    0.0022081 
    NA 
    Welch t-test 
    NA 
    TRUE 
    0.0022081 
    0.00221 
    Welch t-test 
  
 PAI_1 
    continuous 
    label 
    Plasminogen activator inhibitor 1 
    Plasminogen activator inhibitor 1 
    -0.01 (0.38) 
    0.26 (0.44) 
    0.0000007 
    NA 
    Welch t-test 
    NA 
    TRUE 
    0.0000007 
    <0.001 
    Welch t-test 
  
 PAPP_A 
    continuous 
    label 
    Pregnancy-associated plasma protein A 
    Pregnancy-associated plasma protein A 
    -2.85 (0.14) 
    -2.85 (0.14) 
    0.9612735 
    NA 
    Welch t-test 
    NA 
    TRUE 
    0.9612735 
    0.961 
    Welch t-test 
  
 PLGF 
    continuous 
    label 
    Placental growth factor 
    Placental growth factor 
    3.87 (0.39) 
    4.01 (0.42) 
    0.0045508 
    NA 
    Welch t-test 
    NA 
    TRUE 
    0.0045508 
    0.00455 
    Welch t-test 
  
 PYY 
    continuous 
    label 
    Peptide YY 
    Peptide YY 
    3.01 (0.29) 
    3.01 (0.28) 
    0.8747602 
    NA 
    Welch t-test 
    NA 
    TRUE 
    0.8747602 
    0.875 
    Welch t-test 
  
 Pancreatic_polypeptide 
    continuous 
    label 
    Pancreatic polypeptide 
    Pancreatic polypeptide 
    -0.14 (0.67) 
    0.32 (0.74) 
    0.0000008 
    NA 
    Welch t-test 
    NA 
    TRUE 
    0.0000008 
    <0.001 
    Welch t-test 
  
 Prolactin 
    continuous 
    label 
    Prolactin 
    Prolactin 
    0.03 (0.30) 
    0.09 (0.27) 
    0.1059084 
    NA 
    Welch t-test 
    NA 
    TRUE 
    0.1059084 
    0.106 
    Welch t-test 
  
 Prostatic_Acid_Phosphatase 
    continuous 
    label 
    Prostatic acid phosphatase 
    Prostatic acid phosphatase 
    -1.69 (0.06) 
    -1.68 (0.06) 
    0.0631539 
    NA 
    Welch t-test 
    NA 
    TRUE 
    0.0631539 
    0.0632 
    Welch t-test 
  
 Protein_S 
    continuous 
    label 
    Protein S 
    Protein S 
    -2.27 (0.36) 
    -2.17 (0.37) 
    0.0181327 
    NA 
    Welch t-test 
    NA 
    TRUE 
    0.0181327 
    0.0181 
    Welch t-test 
  
 Pulmonary_and_Activation_Regulat 
    continuous 
    label 
    Pulmonary and activation-regulated chemokine 
    Pulmonary and activation-regulated chemokine 
    -1.56 (0.47) 
    -1.47 (0.35) 
    0.1259992 
    NA 
    Welch t-test 
    NA 
    TRUE 
    0.1259992 
    0.126 
    Welch t-test 
  
 RANTES 
    continuous 
    label 
    Regulated on activation, normal T cell expressed and secreted 
    Regulated on activation, normal T cell expressed and secreted 
    -6.55 (0.31) 
    -6.44 (0.31) 
    0.0044494 
    NA 
    Welch t-test 
    NA 
    TRUE 
    0.0044494 
    0.00445 
    Welch t-test 
  
 Resistin 
    continuous 
    label 
    Resistin 
    Resistin 
    -18.52 (5.42) 
    -15.74 (5.93) 
    0.0001487 
    NA 
    Welch t-test 
    NA 
    TRUE 
    0.0001487 
    <0.001 
    Welch t-test 
  
 S100b 
    continuous 
    label 
    S100 calcium-binding protein B 
    S100 calcium-binding protein B 
    1.21 (0.35) 
    1.32 (0.34) 
    0.0078991 
    NA 
    Welch t-test 
    NA 
    TRUE 
    0.0078991 
    0.0079 
    Welch t-test 
  
 SGOT 
    continuous 
    label 
    Serum glutamic-oxaloacetic transaminase 
    Serum glutamic-oxaloacetic transaminase 
    -0.44 (0.37) 
    -0.37 (0.29) 
    0.0469909 
    NA 
    Welch t-test 
    NA 
    TRUE 
    0.0469909 
    0.047 
    Welch t-test 
  
 SHBG 
    continuous 
    label 
    Sex hormone-binding globulin 
    Sex hormone-binding globulin 
    -2.54 (0.57) 
    -2.45 (0.56) 
    0.1686214 
    NA 
    Welch t-test 
    NA 
    TRUE 
    0.1686214 
    0.169 
    Welch t-test 
  
 SOD 
    continuous 
    label 
    Superoxide dismutase 
    Superoxide dismutase 
    5.31 (0.38) 
    5.39 (0.38) 
    0.0833871 
    NA 
    Welch t-test 
    NA 
    TRUE 
    0.0833871 
    0.0834 
    Welch t-test 
  
 Serum_Amyloid_P 
    continuous 
    label 
    Serum amyloid P component 
    Serum amyloid P component 
    -6.05 (0.55) 
    -5.98 (0.57) 
    0.3236618 
    NA 
    Welch t-test 
    NA 
    TRUE 
    0.3236618 
    0.324 
    Welch t-test 
  
 Sortilin 
    continuous 
    label 
    Sortilin 
    Sortilin 
    3.74 (0.86) 
    4.10 (0.83) 
    0.0005339 
    NA 
    Welch t-test 
    NA 
    TRUE 
    0.0005339 
    <0.001 
    Welch t-test 
  
 Stem_Cell_Factor 
    continuous 
    label 
    Stem cell factor 
    Stem cell factor 
    3.30 (0.36) 
    3.28 (0.34) 
    0.6843984 
    NA 
    Welch t-test 
    NA 
    TRUE 
    0.6843984 
    0.684 
    Welch t-test 
  
 TGF_alpha 
    continuous 
    label 
    Transforming growth factor alpha 
    Transforming growth factor alpha 
    9.73 (1.31) 
    9.96 (1.18) 
    0.1283139 
    NA 
    Welch t-test 
    NA 
    TRUE 
    0.1283139 
    0.128 
    Welch t-test 
  
 TIMP_1 
    continuous 
    label 
    Tissue inhibitor of metalloproteinases 1 
    Tissue inhibitor of metalloproteinases 1 
    11.55 (1.78) 
    12.11 (1.97) 
    0.0209928 
    NA 
    Welch t-test 
    NA 
    TRUE 
    0.0209928 
    0.021 
    Welch t-test 
  
 TNF_RII 
    continuous 
    label 
    Tumor necrosis factor receptor II 
    Tumor necrosis factor receptor II 
    -0.64 (0.32) 
    -0.48 (0.35) 
    0.0002205 
    NA 
    Welch t-test 
    NA 
    TRUE 
    0.0002205 
    <0.001 
    Welch t-test 
  
 TRAIL_R3 
    continuous 
    label 
    TNF-related apoptosis-inducing ligand receptor 3 
    TNF-related apoptosis-inducing ligand receptor 3 
    -0.59 (0.23) 
    -0.43 (0.23) 
    0.0000001 
    NA 
    Welch t-test 
    NA 
    TRUE 
    0.0000001 
    <0.001 
    Welch t-test 
  
 TTR_prealbumin 
    continuous 
    label 
    Transthyretin (prealbumin) 
    Transthyretin (prealbumin) 
    2.86 (0.14) 
    2.84 (0.14) 
    0.4396330 
    NA 
    Welch t-test 
    NA 
    TRUE 
    0.4396330 
    0.44 
    Welch t-test 
  
 Tamm_Horsfall_Protein_THP 
    continuous 
    label 
    Tamm-Horsfall protein 
    Tamm-Horsfall protein 
    -3.12 (0.03) 
    -3.11 (0.03) 
    0.3283328 
    NA 
    Welch t-test 
    NA 
    TRUE 
    0.3283328 
    0.328 
    Welch t-test 
  
 Thrombomodulin 
    continuous 
    label 
    Thrombomodulin 
    Thrombomodulin 
    -1.53 (0.23) 
    -1.45 (0.22) 
    0.0028089 
    NA 
    Welch t-test 
    NA 
    TRUE 
    0.0028089 
    0.00281 
    Welch t-test 
  
 Thrombopoietin 
    continuous 
    label 
    Thrombopoietin 
    Thrombopoietin 
    -0.74 (0.24) 
    -0.81 (0.25) 
    0.0630863 
    NA 
    Welch t-test 
    NA 
    TRUE 
    0.0630863 
    0.0631 
    Welch t-test 
  
 Thymus_Expressed_Chemokine_TECK 
    continuous 
    label 
    Thymus-expressed chemokine (TECK) 
    Thymus-expressed chemokine (TECK) 
    3.73 (0.77) 
    4.11 (0.76) 
    0.0000606 
    NA 
    Welch t-test 
    NA 
    TRUE 
    0.0000606 
    <0.001 
    Welch t-test 
  
 Thyroid_Stimulating_Hormone 
    continuous 
    label 
    Thyroid-stimulating hormone 
    Thyroid-stimulating hormone 
    -4.45 (0.75) 
    -4.43 (0.82) 
    0.8817515 
    NA 
    Welch t-test 
    NA 
    TRUE 
    0.8817515 
    0.882 
    Welch t-test 
  
 Thyroxine_Binding_Globulin 
    continuous 
    label 
    Thyroxine-binding globulin 
    Thyroxine-binding globulin 
    -1.51 (0.40) 
    -1.42 (0.39) 
    0.0668355 
    NA 
    Welch t-test 
    NA 
    TRUE 
    0.0668355 
    0.0668 
    Welch t-test 
  
 Tissue_Factor 
    continuous 
    label 
    Tissue factor 
    Tissue factor 
    1.16 (0.51) 
    1.18 (0.51) 
    0.7382965 
    NA 
    Welch t-test 
    NA 
    TRUE 
    0.7382965 
    0.738 
    Welch t-test 
  
 Transferrin 
    continuous 
    label 
    Transferrin 
    Transferrin 
    2.90 (0.28) 
    2.92 (0.27) 
    0.5677089 
    NA 
    Welch t-test 
    NA 
    TRUE 
    0.5677089 
    0.568 
    Welch t-test 
  
 Trefoil_Factor_3_TFF3 
    continuous 
    label 
    Trefoil factor 3 (TFF3) 
    Trefoil factor 3 (TFF3) 
    -3.90 (0.33) 
    -3.85 (0.36) 
    0.2500022 
    NA 
    Welch t-test 
    NA 
    TRUE 
    0.2500022 
    0.25 
    Welch t-test 
  
 VCAM_1 
    continuous 
    label 
    Vascular cell adhesion molecule 1 
    Vascular cell adhesion molecule 1 
    2.66 (0.30) 
    2.73 (0.37) 
    0.0887835 
    NA 
    Welch t-test 
    NA 
    TRUE 
    0.0887835 
    0.0888 
    Welch t-test 
  
 VEGF 
    continuous 
    label 
    Vascular endothelial growth factor 
    Vascular endothelial growth factor 
    17.14 (1.85) 
    16.37 (1.83) 
    0.0008075 
    NA 
    Welch t-test 
    NA 
    TRUE 
    0.0008075 
    <0.001 
    Welch t-test 
  
 Vitronectin 
    continuous 
    label 
    Vitronectin 
    Vitronectin 
    -0.28 (0.33) 
    -0.28 (0.32) 
    0.9569334 
    NA 
    Welch t-test 
    NA 
    TRUE 
    0.9569334 
    0.957 
    Welch t-test 
  
 von_Willebrand_Factor 
    continuous 
    label 
    von Willebrand factor 
    von Willebrand factor 
    -3.95 (0.37) 
    -3.86 (0.39) 
    0.0473700 
    NA 
    Welch t-test 
    NA 
    TRUE 
    0.0473700 
    0.0474 
    Welch t-test 
  
 tau 
    continuous 
    label 
    Tau protein 
    Tau protein 
    5.61 (0.49) 
    6.14 (0.55) 
    0.0000000 
    NA 
    Welch t-test 
    NA 
    TRUE 
    0.0000000 
    <0.001 
    Welch t-test 
  
 p_tau 
    continuous 
    label 
    Phosphorylated tau protein 
    Phosphorylated tau protein 
    3.94 (0.42) 
    4.30 (0.48) 
    0.0000000 
    NA 
    Welch t-test 
    NA 
    TRUE 
    0.0000000 
    <0.001 
    Welch t-test 
  
 Ab_42 
    continuous 
    label 
    Amyloid beta 42 
    Amyloid beta 42 
    12.80 (1.41) 
    11.27 (1.34) 
    0.0000000 
    NA 
    Welch t-test 
    NA 
    TRUE 
    0.0000000 
    <0.001 
    Welch t-test 
  
 age 
    continuous 
    label 
    Age 
    Age 
    72.75 (13.26) 
    71.78 (13.12) 
    0.5526369 
    NA 
    Welch t-test 
    NA 
    TRUE 
    0.5526369 
    0.553 
    Welch t-test 
  
 sex 
    categorical 
    label 
    Sex 
    Sex 
    NA 
    NA 
    0.0272353 
    NA 
    Pearson chi-squared 
    NA 
    TRUE 
    0.0272353 
    0.0272 
    Pearson chi-squared 
  
 sex 
    categorical 
    level 
    Sex 
    Female 
    157 (65%) 
    47 (52%) 
    0.0272353 
    NA 
    Pearson chi-squared 
    NA 
    FALSE 
    0.0272353 
    NA 
    NA 
  
 sex 
    categorical 
    level 
    Sex 
    Male 
    85 (35%) 
    44 (48%) 
    0.0272353 
    NA 
    Pearson chi-squared 
    NA 
    FALSE 
    0.0272353 
    NA 
    NA 
  
 Genotype 
    categorical 
    label 
    Genotype 
    Genotype 
    NA 
    NA 
    0.0005999 
    NA 
    Fisher (sim.) 
    NA 
    TRUE 
    0.0005999 
    <0.001 
    Fisher (sim.) 
  
 Genotype 
    categorical 
    level 
    Genotype 
    E2E2 
    2 (0.8%) 
    0 (0%) 
    0.0005999 
    NA 
    Fisher (sim.) 
    NA 
    FALSE 
    0.0005999 
    NA 
    NA 
  
 Genotype 
    categorical 
    level 
    Genotype 
    E2E3 
    30 (12%) 
    7 (7.7%) 
    0.0005999 
    NA 
    Fisher (sim.) 
    NA 
    FALSE 
    0.0005999 
    NA 
    NA 
  
 Genotype 
    categorical 
    level 
    Genotype 
    E2E4 
    7 (2.9%) 
    1 (1.1%) 
    0.0005999 
    NA 
    Fisher (sim.) 
    NA 
    FALSE 
    0.0005999 
    NA 
    NA 
  
 Genotype 
    categorical 
    level 
    Genotype 
    E3E3 
    133 (55%) 
    34 (37%) 
    0.0005999 
    NA 
    Fisher (sim.) 
    NA 
    FALSE 
    0.0005999 
    NA 
    NA 
  
 Genotype 
    categorical 
    level 
    Genotype 
    E3E4 
    65 (27%) 
    41 (45%) 
    0.0005999 
    NA 
    Fisher (sim.) 
    NA 
    FALSE 
    0.0005999 
    NA 
    NA 
  
 Genotype 
    categorical 
    level 
    Genotype 
    E4E4 
    5 (2.1%) 
    8 (8.8%) 
    0.0005999 
    NA 
    Fisher (sim.) 
    NA 
    FALSE 
    0.0005999 
    NA 
    NA 
  
 ACE_CD143_Angiotensin_Converti 
    continuous 
    label 
    Angiotensin-converting enzyme 
    Angiotensin-converting enzyme 
    1.32 (0.56) 
    1.31 (0.53) 
    0.8846265 
    NA 
    Welch t-test 
    NA 
    TRUE 
    0.8846265 
    0.885 
    Welch t-test 
  
 ACTH_Adrenocorticotropic_Hormon 
    continuous 
    label 
    Adrenocorticotropic hormone 
    Adrenocorticotropic hormone 
    -1.55 (0.27) 
    -1.51 (0.29) 
    0.3228133 
    NA 
    Welch t-test 
    NA 
    TRUE 
    0.3228133 
    0.323 
    Welch t-test 
  
 AXL 
    continuous 
    label 
    AXL receptor tyrosine kinase 
    AXL receptor tyrosine kinase 
    0.28 (0.46) 
    0.34 (0.41) 
    0.2384182 
    NA 
    Welch t-test 
    NA 
    TRUE 
    0.2384182 
    0.238 
    Welch t-test 
  
 Adiponectin 
    continuous 
    label 
    Adiponectin 
    Adiponectin 
    -5.26 (0.65) 
    -5.10 (0.69) 
    0.0538971 
    NA 
    Welch t-test 
    NA 
    TRUE 
    0.0538971 
    0.0539 
    Welch t-test 
  
 Alpha_1_Antichymotrypsin 
    continuous 
    label 
    Alpha-1-antichymotrypsin 
    Alpha-1-antichymotrypsin 
    1.32 (0.36) 
    1.44 (0.37) 
    0.0096393 
    NA 
    Welch t-test 
    NA 
    TRUE 
    0.0096393 
    0.00964 
    Welch t-test 
  
 Alpha_1_Antitrypsin 
    continuous 
    label 
    Alpha-1-antitrypsin 
    Alpha-1-antitrypsin 
    -13.33 (1.51) 
    -12.62 (1.52) 
    0.0001841 
    NA 
    Welch t-test 
    NA 
    TRUE 
    0.0001841 
    <0.001 
    Welch t-test 
  
 Alpha_1_Microglobulin 
    continuous 
    label 
    Alpha-1-microglobulin 
    Alpha-1-microglobulin 
    -2.99 (0.48) 
    -2.82 (0.45) 
    0.0030400 
    NA 
    Welch t-test 
    NA 
    TRUE 
    0.0030400 
    0.00304 
    Welch t-test 
  
 Alpha_2_Macroglobulin 
    continuous 
    label 
    Alpha-2-macroglobulin 
    Alpha-2-macroglobulin 
    -162.49 (41.36) 
    -151.41 (38.78) 
    0.0237020 
    NA 
    Welch t-test 
    NA 
    TRUE 
    0.0237020 
    0.0237 
    Welch t-test 
  
 Angiopoietin_2_ANG_2 
    continuous 
    label 
    Angiopoietin-2 
    Angiopoietin-2 
    0.65 (0.33) 
    0.70 (0.34) 
    0.2243927 
    NA 
    Welch t-test 
    NA 
    TRUE 
    0.2243927 
    0.224 
    Welch t-test 
  
 Angiotensinogen 
    continuous 
    label 
    Angiotensinogen 
    Angiotensinogen 
    2.31 (0.25) 
    2.38 (0.25) 
    0.0363220 
    NA 
    Welch t-test 
    NA 
    TRUE 
    0.0363220 
    0.0363 
    Welch t-test 
  
 Apolipoprotein_A_IV 
    continuous 
    label 
    Apolipoprotein A-IV 
    Apolipoprotein A-IV 
    -1.86 (0.39) 
    -1.84 (0.37) 
    0.6196039 
    NA 
    Welch t-test 
    NA 
    TRUE 
    0.6196039 
    0.62 
    Welch t-test 
  
 Apolipoprotein_A1 
    continuous 
    label 
    Apolipoprotein A-1 
    Apolipoprotein A-1 
    -7.48 (0.43) 
    -7.50 (0.44) 
    0.6901145 
    NA 
    Welch t-test 
    NA 
    TRUE 
    0.6901145 
    0.69 
    Welch t-test 
  
 Apolipoprotein_A2 
    continuous 
    label 
    Apolipoprotein A-2 
    Apolipoprotein A-2 
    -0.66 (0.50) 
    -0.61 (0.48) 
    0.3909281 
    NA 
    Welch t-test 
    NA 
    TRUE 
    0.3909281 
    0.391 
    Welch t-test 
  
 Apolipoprotein_B 
    continuous 
    label 
    Apolipoprotein B 
    Apolipoprotein B 
    -5.71 (1.40) 
    -5.27 (1.55) 
    0.0183210 
    NA 
    Welch t-test 
    NA 
    TRUE 
    0.0183210 
    0.0183 
    Welch t-test 
  
 Apolipoprotein_CI 
    continuous 
    label 
    Apolipoprotein C-I 
    Apolipoprotein C-I 
    -1.60 (0.41) 
    -1.58 (0.45) 
    0.8186647 
    NA 
    Welch t-test 
    NA 
    TRUE 
    0.8186647 
    0.819 
    Welch t-test 
  
 Apolipoprotein_CIII 
    continuous 
    label 
    Apolipoprotein C-III 
    Apolipoprotein C-III 
    -2.53 (0.44) 
    -2.42 (0.44) 
    0.0350373 
    NA 
    Welch t-test 
    NA 
    TRUE 
    0.0350373 
    0.035 
    Welch t-test 
  
 Apolipoprotein_D 
    continuous 
    label 
    Apolipoprotein D 
    Apolipoprotein D 
    1.39 (0.33) 
    1.54 (0.38) 
    0.0015555 
    NA 
    Welch t-test 
    NA 
    TRUE 
    0.0015555 
    0.00156 
    Welch t-test 
  
 Apolipoprotein_E 
    continuous 
    label 
    Apolipoprotein E 
    Apolipoprotein E 
    2.79 (0.77) 
    2.78 (0.87) 
    0.8668217 
    NA 
    Welch t-test 
    NA 
    TRUE 
    0.8668217 
    0.867 
    Welch t-test 
  
 Apolipoprotein_H 
    continuous 
    label 
    Apolipoprotein H 
    Apolipoprotein H 
    -0.35 (0.38) 
    -0.23 (0.38) 
    0.0106232 
    NA 
    Welch t-test 
    NA 
    TRUE 
    0.0106232 
    0.0106 
    Welch t-test 
  
 B_Lymphocyte_Chemoattractant_BL 
    continuous 
    label 
    B-lymphocyte chemoattractant 
    B-lymphocyte chemoattractant 
    1.92 (0.57) 
    2.16 (0.56) 
    0.0007177 
    NA 
    Welch t-test 
    NA 
    TRUE 
    0.0007177 
    <0.001 
    Welch t-test 
  
 BMP_6 
    continuous 
    label 
    Bone morphogenetic protein 6 
    Bone morphogenetic protein 6 
    -1.89 (0.29) 
    -1.92 (0.33) 
    0.5218752 
    NA 
    Welch t-test 
    NA 
    TRUE 
    0.5218752 
    0.522 
    Welch t-test 
  
 Beta_2_Microglobulin 
    continuous 
    label 
    Beta-2-microglobulin 
    Beta-2-microglobulin 
    0.16 (0.29) 
    0.19 (0.31) 
    0.4233981 
    NA 
    Welch t-test 
    NA 
    TRUE 
    0.4233981 
    0.423 
    Welch t-test 
  
 Betacellulin 
    continuous 
    label 
    Betacellulin 
    Betacellulin 
    51.63 (10.91) 
    50.62 (10.60) 
    0.4399492 
    NA 
    Welch t-test 
    NA 
    TRUE 
    0.4399492 
    0.44 
    Welch t-test 
  
 C_Reactive_Protein 
    continuous 
    label 
    C-reactive protein 
    C-reactive protein 
    -5.87 (1.22) 
    -5.97 (1.14) 
    0.4843525 
    NA 
    Welch t-test 
    NA 
    TRUE 
    0.4843525 
    0.484 
    Welch t-test 
  
 CD40 
    continuous 
    label 
    CD40 
    CD40 
    -1.26 (0.21) 
    -1.28 (0.24) 
    0.5003297 
    NA 
    Welch t-test 
    NA 
    TRUE 
    0.5003297 
    0.5 
    Welch t-test 
  
 CD5L 
    continuous 
    label 
    CD5L 
    CD5L 
    -0.10 (0.44) 
    0.04 (0.49) 
    0.0247260 
    NA 
    Welch t-test 
    NA 
    TRUE 
    0.0247260 
    0.0247 
    Welch t-test 
  
 Calbindin 
    continuous 
    label 
    Calbindin 
    Calbindin 
    21.99 (3.90) 
    22.93 (4.85) 
    0.1011017 
    NA 
    Welch t-test 
    NA 
    TRUE 
    0.1011017 
    0.101 
    Welch t-test 
  
 Calcitonin 
    continuous 
    label 
    Calcitonin 
    Calcitonin 
    1.68 (0.85) 
    1.71 (0.94) 
    0.7808643 
    NA 
    Welch t-test 
    NA 
    TRUE 
    0.7808643 
    0.781 
    Welch t-test 
  
 CgA 
    continuous 
    label 
    Chromogranin A 
    Chromogranin A 
    329.78 (82.65) 
    333.17 (81.12) 
    0.7351867 
    NA 
    Welch t-test 
    NA 
    TRUE 
    0.7351867 
    0.735 
    Welch t-test 
  
 Clusterin_Apo_J 
    continuous 
    label 
    Clusterin (ApoJ) 
    Clusterin (ApoJ) 
    2.85 (0.29) 
    2.95 (0.33) 
    0.0116372 
    NA 
    Welch t-test 
    NA 
    TRUE 
    0.0116372 
    0.0116 
    Welch t-test 
  
 Complement_3 
    continuous 
    label 
    Complement component 3 
    Complement component 3 
    -15.95 (2.45) 
    -14.92 (2.43) 
    0.0007632 
    NA 
    Welch t-test 
    NA 
    TRUE 
    0.0007632 
    <0.001 
    Welch t-test 
  
 Complement_Factor_H 
    continuous 
    label 
    Complement factor H 
    Complement factor H 
    3.48 (1.26) 
    3.62 (1.22) 
    0.3580892 
    NA 
    Welch t-test 
    NA 
    TRUE 
    0.3580892 
    0.358 
    Welch t-test 
  
 Connective_Tissue_Growth_Factor 
    continuous 
    label 
    Connective tissue growth factor 
    Connective tissue growth factor 
    0.76 (0.21) 
    0.79 (0.20) 
    0.2752610 
    NA 
    Welch t-test 
    NA 
    TRUE 
    0.2752610 
    0.275 
    Welch t-test 
  
 Cortisol 
    continuous 
    label 
    Cortisol 
    Cortisol 
    11.22 (3.73) 
    12.93 (4.34) 
    0.0011179 
    NA 
    Welch t-test 
    NA 
    TRUE 
    0.0011179 
    0.00112 
    Welch t-test 
  
 Creatine_Kinase_MB 
    continuous 
    label 
    Creatine kinase-MB 
    Creatine kinase-MB 
    -1.66 (0.10) 
    -1.70 (0.08) 
    0.0001039 
    NA 
    Welch t-test 
    NA 
    TRUE 
    0.0001039 
    <0.001 
    Welch t-test 
  
 Cystatin_C 
    continuous 
    label 
    Cystatin C 
    Cystatin C 
    8.62 (0.40) 
    8.48 (0.40) 
    0.0055073 
    NA 
    Welch t-test 
    NA 
    TRUE 
    0.0055073 
    0.00551 
    Welch t-test 
  
 EGF_R 
    continuous 
    label 
    Epidermal growth factor receptor 
    Epidermal growth factor receptor 
    -0.71 (0.24) 
    -0.68 (0.22) 
    0.4379144 
    NA 
    Welch t-test 
    NA 
    TRUE 
    0.4379144 
    0.438 
    Welch t-test 
  
 EN_RAGE 
    continuous 
    label 
    EN-RAGE (extracellular newly identified RAGE-binding protein) 
    EN-RAGE (extracellular newly identified RAGE-binding protein) 
    -3.62 (0.90) 
    -3.65 (0.88) 
    0.7659387 
    NA 
    Welch t-test 
    NA 
    TRUE 
    0.7659387 
    0.766 
    Welch t-test 
  
 ENA_78 
    continuous 
    label 
    ENA-78 (epithelial-derived neutrophil-activating protein 78) 
    ENA-78 (epithelial-derived neutrophil-activating protein 78) 
    -1.37 (0.01) 
    -1.37 (0.01) 
    0.9254390 
    NA 
    Welch t-test 
    NA 
    TRUE 
    0.9254390 
    0.925 
    Welch t-test 
  
 Eotaxin_3 
    continuous 
    label 
    Eotaxin-3 
    Eotaxin-3 
    55.36 (15.98) 
    63.75 (15.86) 
    0.0000303 
    NA 
    Welch t-test 
    NA 
    TRUE 
    0.0000303 
    <0.001 
    Welch t-test 
  
 FAS 
    continuous 
    label 
    Fas (tumor necrosis factor receptor superfamily member 6) 
    Fas (tumor necrosis factor receptor superfamily member 6) 
    -0.58 (0.28) 
    -0.40 (0.31) 
    0.0000019 
    NA 
    Welch t-test 
    NA 
    TRUE 
    0.0000019 
    <0.001 
    Welch t-test 
  
 FSH_Follicle_Stimulation_Hormon 
    continuous 
    label 
    Follicle-stimulating hormone 
    Follicle-stimulating hormone 
    -1.12 (0.39) 
    -1.15 (0.43) 
    0.6164374 
    NA 
    Welch t-test 
    NA 
    TRUE 
    0.6164374 
    0.616 
    Welch t-test 
  
 Fas_Ligand 
    continuous 
    label 
    Fas ligand 
    Fas ligand 
    2.79 (1.05) 
    3.22 (1.12) 
    0.0015514 
    NA 
    Welch t-test 
    NA 
    TRUE 
    0.0015514 
    0.00155 
    Welch t-test 
  
 Fatty_Acid_Binding_Protein 
    continuous 
    label 
    Fatty acid-binding protein 
    Fatty acid-binding protein 
    1.24 (0.73) 
    1.59 (0.86) 
    0.0007710 
    NA 
    Welch t-test 
    NA 
    TRUE 
    0.0007710 
    <0.001 
    Welch t-test 
  
 Ferritin 
    continuous 
    label 
    Ferritin 
    Ferritin 
    2.70 (0.76) 
    2.90 (0.83) 
    0.0426440 
    NA 
    Welch t-test 
    NA 
    TRUE 
    0.0426440 
    0.0426 
    Welch t-test 
  
 Fetuin_A 
    continuous 
    label 
    Fetuin-A 
    Fetuin-A 
    1.32 (0.40) 
    1.44 (0.34) 
    0.0314522 
    NA 
    Welch t-test 
    NA 
    TRUE 
    0.0314522 
    0.0315 
    Welch t-test 
  
 Fibrinogen 
    continuous 
    label 
    Fibrinogen 
    Fibrinogen 
    -7.45 (0.56) 
    -7.12 (0.57) 
    0.0000075 
    NA 
    Welch t-test 
    NA 
    TRUE 
    0.0000075 
    <0.001 
    Welch t-test 
  
 GRO_alpha 
    continuous 
    label 
    Growth-regulated alpha protein 
    Growth-regulated alpha protein 
    1.37 (0.04) 
    1.40 (0.04) 
    0.0000000 
    NA 
    Welch t-test 
    NA 
    TRUE 
    0.0000000 
    <0.001 
    Welch t-test 
  
 Gamma_Interferon_induced_Monokin 
    continuous 
    label 
    Gamma interferon-induced monokine 
    Gamma interferon-induced monokine 
    2.77 (0.11) 
    2.83 (0.10) 
    0.0000059 
    NA 
    Welch t-test 
    NA 
    TRUE 
    0.0000059 
    <0.001 
    Welch t-test 
  
 Glutathione_S_Transferase_alpha 
    continuous 
    label 
    Glutathione S-transferase alpha 
    Glutathione S-transferase alpha 
    0.95 (0.17) 
    0.96 (0.12) 
    0.5459600 
    NA 
    Welch t-test 
    NA 
    TRUE 
    0.5459600 
    0.546 
    Welch t-test 
  
 HB_EGF 
    continuous 
    label 
    Heparin-binding epidermal growth factor 
    Heparin-binding epidermal growth factor 
    6.70 (1.47) 
    7.20 (1.49) 
    0.0061319 
    NA 
    Welch t-test 
    NA 
    TRUE 
    0.0061319 
    0.00613 
    Welch t-test 
  
 HCC_4 
    continuous 
    label 
    HCC-4 (hemofiltrate CC chemokine-4) 
    HCC-4 (hemofiltrate CC chemokine-4) 
    -3.55 (0.36) 
    -3.40 (0.34) 
    0.0005695 
    NA 
    Welch t-test 
    NA 
    TRUE 
    0.0005695 
    <0.001 
    Welch t-test 
  
 Hepatocyte_Growth_Factor_HGF 
    continuous 
    label 
    Hepatocyte growth factor 
    Hepatocyte growth factor 
    0.17 (0.29) 
    0.27 (0.29) 
    0.0051215 
    NA 
    Welch t-test 
    NA 
    TRUE 
    0.0051215 
    0.00512 
    Welch t-test 
  
 I_309 
    continuous 
    label 
    I-309 (TCA-3) 
    I-309 (TCA-3) 
    2.92 (0.36) 
    3.02 (0.39) 
    0.0337660 
    NA 
    Welch t-test 
    NA 
    TRUE 
    0.0337660 
    0.0338 
    Welch t-test 
  
 ICAM_1 
    continuous 
    label 
    Intercellular adhesion molecule 1 
    Intercellular adhesion molecule 1 
    -0.60 (0.32) 
    -0.56 (0.36) 
    0.3368872 
    NA 
    Welch t-test 
    NA 
    TRUE 
    0.3368872 
    0.337 
    Welch t-test 
  
 IGF_BP_2 
    continuous 
    label 
    Insulin-like growth factor-binding protein 2 
    Insulin-like growth factor-binding protein 2 
    5.28 (0.20) 
    5.38 (0.22) 
    0.0001243 
    NA 
    Welch t-test 
    NA 
    TRUE 
    0.0001243 
    <0.001 
    Welch t-test 
  
 IL_11 
    continuous 
    label 
    Interleukin 11 
    Interleukin 11 
    4.73 (1.39) 
    4.65 (1.53) 
    0.6424064 
    NA 
    Welch t-test 
    NA 
    TRUE 
    0.6424064 
    0.642 
    Welch t-test 
  
 IL_13 
    continuous 
    label 
    Interleukin 13 
    Interleukin 13 
    1.28 (0.01) 
    1.28 (0.01) 
    0.2577007 
    NA 
    Welch t-test 
    NA 
    TRUE 
    0.2577007 
    0.258 
    Welch t-test 
  
 IL_16 
    continuous 
    label 
    Interleukin 16 
    Interleukin 16 
    2.91 (0.67) 
    2.91 (0.65) 
    0.9601492 
    NA 
    Welch t-test 
    NA 
    TRUE 
    0.9601492 
    0.96 
    Welch t-test 
  
 IL_17E 
    continuous 
    label 
    Interleukin 17E 
    Interleukin 17E 
    4.95 (1.41) 
    4.55 (1.07) 
    0.0057222 
    NA 
    Welch t-test 
    NA 
    TRUE 
    0.0057222 
    0.00572 
    Welch t-test 
  
 IL_1alpha 
    continuous 
    label 
    Interleukin 1 alpha 
    Interleukin 1 alpha 
    -7.54 (0.39) 
    -7.48 (0.43) 
    0.3035679 
    NA 
    Welch t-test 
    NA 
    TRUE 
    0.3035679 
    0.304 
    Welch t-test 
  
 IL_3 
    continuous 
    label 
    Interleukin 3 
    Interleukin 3 
    -3.93 (0.51) 
    -3.99 (0.50) 
    0.4067009 
    NA 
    Welch t-test 
    NA 
    TRUE 
    0.4067009 
    0.407 
    Welch t-test 
  
 IL_4 
    continuous 
    label 
    Interleukin 4 
    Interleukin 4 
    1.78 (0.50) 
    1.72 (0.53) 
    0.3623877 
    NA 
    Welch t-test 
    NA 
    TRUE 
    0.3623877 
    0.362 
    Welch t-test 
  
 IL_5 
    continuous 
    label 
    Interleukin 5 
    Interleukin 5 
    0.21 (0.46) 
    0.17 (0.44) 
    0.4598690 
    NA 
    Welch t-test 
    NA 
    TRUE 
    0.4598690 
    0.46 
    Welch t-test 
  
 IL_6 
    continuous 
    label 
    Interleukin 6 
    Interleukin 6 
    -0.15 (0.51) 
    -0.14 (0.62) 
    0.9841252 
    NA 
    Welch t-test 
    NA 
    TRUE 
    0.9841252 
    0.984 
    Welch t-test 
  
 IL_6_Receptor 
    continuous 
    label 
    Interleukin 6 receptor 
    Interleukin 6 receptor 
    0.09 (0.32) 
    0.08 (0.34) 
    0.8068581 
    NA 
    Welch t-test 
    NA 
    TRUE 
    0.8068581 
    0.807 
    Welch t-test 
  
 IL_7 
    continuous 
    label 
    Interleukin 7 
    Interleukin 7 
    3.01 (0.99) 
    2.61 (1.04) 
    0.0017584 
    NA 
    Welch t-test 
    NA 
    TRUE 
    0.0017584 
    0.00176 
    Welch t-test 
  
 IL_8 
    continuous 
    label 
    Interleukin 8 
    Interleukin 8 
    1.70 (0.03) 
    1.71 (0.04) 
    0.0318468 
    NA 
    Welch t-test 
    NA 
    TRUE 
    0.0318468 
    0.0318 
    Welch t-test 
  
 IP_10_Inducible_Protein_10 
    continuous 
    label 
    Inducible protein 10 
    Inducible protein 10 
    5.69 (0.51) 
    5.85 (0.48) 
    0.0084555 
    NA 
    Welch t-test 
    NA 
    TRUE 
    0.0084555 
    0.00846 
    Welch t-test 
  
 IgA 
    continuous 
    label 
    Immunoglobulin A 
    Immunoglobulin A 
    -6.17 (0.75) 
    -5.94 (0.69) 
    0.0078162 
    NA 
    Welch t-test 
    NA 
    TRUE 
    0.0078162 
    0.00782 
    Welch t-test 
  
 Insulin 
    continuous 
    label 
    Insulin 
    Insulin 
    -1.21 (0.33) 
    -1.26 (0.36) 
    0.2895756 
    NA 
    Welch t-test 
    NA 
    TRUE 
    0.2895756 
    0.29 
    Welch t-test 
  
 Kidney_Injury_Molecule_1_KIM_1 
    continuous 
    label 
    Kidney injury molecule 1 
    Kidney injury molecule 1 
    -1.19 (0.03) 
    -1.18 (0.02) 
    0.0048740 
    NA 
    Welch t-test 
    NA 
    TRUE 
    0.0048740 
    0.00487 
    Welch t-test 
  
 LOX_1 
    continuous 
    label 
    Lectin-like oxidized LDL receptor 1 
    Lectin-like oxidized LDL receptor 1 
    1.27 (0.40) 
    1.27 (0.45) 
    0.9876103 
    NA 
    Welch t-test 
    NA 
    TRUE 
    0.9876103 
    0.988 
    Welch t-test 
  
 Leptin 
    continuous 
    label 
    Leptin 
    Leptin 
    -1.48 (0.27) 
    -1.53 (0.26) 
    0.0940108 
    NA 
    Welch t-test 
    NA 
    TRUE 
    0.0940108 
    0.094 
    Welch t-test 
  
 Lipoprotein_a 
    continuous 
    label 
    Lipoprotein(a) 
    Lipoprotein(a) 
    -4.51 (1.03) 
    -4.25 (1.16) 
    0.0629993 
    NA 
    Welch t-test 
    NA 
    TRUE 
    0.0629993 
    0.063 
    Welch t-test 
  
 MCP_1 
    continuous 
    label 
    Monocyte chemoattractant protein 1 
    Monocyte chemoattractant protein 1 
    6.48 (0.26) 
    6.52 (0.25) 
    0.1775721 
    NA 
    Welch t-test 
    NA 
    TRUE 
    0.1775721 
    0.178 
    Welch t-test 
  
 MCP_2 
    continuous 
    label 
    Monocyte chemoattractant protein 2 
    Monocyte chemoattractant protein 2 
    1.78 (0.62) 
    2.07 (0.64) 
    0.0002487 
    NA 
    Welch t-test 
    NA 
    TRUE 
    0.0002487 
    <0.001 
    Welch t-test 
  
 MIF 
    continuous 
    label 
    Macrophage migration inhibitory factor 
    Macrophage migration inhibitory factor 
    -1.93 (0.33) 
    -1.74 (0.29) 
    0.0000004 
    NA 
    Welch t-test 
    NA 
    TRUE 
    0.0000004 
    <0.001 
    Welch t-test 
  
 MIP_1alpha 
    continuous 
    label 
    Macrophage inflammatory protein 1 alpha 
    Macrophage inflammatory protein 1 alpha 
    3.94 (1.05) 
    4.24 (0.88) 
    0.0083499 
    NA 
    Welch t-test 
    NA 
    TRUE 
    0.0083499 
    0.00835 
    Welch t-test 
  
 MIP_1beta 
    continuous 
    label 
    Macrophage inflammatory protein 1 beta 
    Macrophage inflammatory protein 1 beta 
    2.79 (0.38) 
    2.87 (0.40) 
    0.0869483 
    NA 
    Welch t-test 
    NA 
    TRUE 
    0.0869483 
    0.0869 
    Welch t-test 
  
 MMP_2 
    continuous 
    label 
    Matrix metalloproteinase 2 
    Matrix metalloproteinase 2 
    2.95 (0.95) 
    2.81 (0.89) 
    0.2122963 
    NA 
    Welch t-test 
    NA 
    TRUE 
    0.2122963 
    0.212 
    Welch t-test 
  
 MMP_3 
    continuous 
    label 
    Matrix metalloproteinase 3 
    Matrix metalloproteinase 3 
    -2.49 (0.56) 
    -2.36 (0.60) 
    0.0738423 
    NA 
    Welch t-test 
    NA 
    TRUE 
    0.0738423 
    0.0738 
    Welch t-test 
  
 MMP10 
    continuous 
    label 
    Matrix metalloproteinase 10 
    Matrix metalloproteinase 10 
    -3.73 (0.40) 
    -3.42 (0.44) 
    0.0000000 
    NA 
    Welch t-test 
    NA 
    TRUE 
    0.0000000 
    <0.001 
    Welch t-test 
  
 MMP7 
    continuous 
    label 
    Matrix metalloproteinase 7 
    Matrix metalloproteinase 7 
    -4.07 (1.58) 
    -3.21 (1.28) 
    0.0000009 
    NA 
    Welch t-test 
    NA 
    TRUE 
    0.0000009 
    <0.001 
    Welch t-test 
  
 Myoglobin 
    continuous 
    label 
    Myoglobin 
    Myoglobin 
    -1.43 (0.96) 
    -1.23 (0.87) 
    0.0755465 
    NA 
    Welch t-test 
    NA 
    TRUE 
    0.0755465 
    0.0755 
    Welch t-test 
  
 NT_proBNP 
    continuous 
    label 
    N-terminal pro b-type natriuretic peptide 
    N-terminal pro b-type natriuretic peptide 
    4.46 (0.36) 
    4.71 (0.36) 
    0.0000038 
    NA 
    Welch t-test 
    NA 
    TRUE 
    0.0000038 
    <0.001 
    Welch t-test 
  
 NrCAM 
    continuous 
    label 
    Neuron-glia cell adhesion molecule 
    Neuron-glia cell adhesion molecule 
    4.38 (0.56) 
    4.33 (0.54) 
    0.5219452 
    NA 
    Welch t-test 
    NA 
    TRUE 
    0.5219452 
    0.522 
    Welch t-test 
  
 Osteopontin 
    continuous 
    label 
    Osteopontin 
    Osteopontin 
    5.16 (0.38) 
    5.31 (0.41) 
    0.0022081 
    NA 
    Welch t-test 
    NA 
    TRUE 
    0.0022081 
    0.00221 
    Welch t-test 
  
 PAI_1 
    continuous 
    label 
    Plasminogen activator inhibitor 1 
    Plasminogen activator inhibitor 1 
    -0.01 (0.38) 
    0.26 (0.44) 
    0.0000007 
    NA 
    Welch t-test 
    NA 
    TRUE 
    0.0000007 
    <0.001 
    Welch t-test 
  
 PAPP_A 
    continuous 
    label 
    Pregnancy-associated plasma protein A 
    Pregnancy-associated plasma protein A 
    -2.85 (0.14) 
    -2.85 (0.14) 
    0.9612735 
    NA 
    Welch t-test 
    NA 
    TRUE 
    0.9612735 
    0.961 
    Welch t-test 
  
 PLGF 
    continuous 
    label 
    Placental growth factor 
    Placental growth factor 
    3.87 (0.39) 
    4.01 (0.42) 
    0.0045508 
    NA 
    Welch t-test 
    NA 
    TRUE 
    0.0045508 
    0.00455 
    Welch t-test 
  
 PYY 
    continuous 
    label 
    Peptide YY 
    Peptide YY 
    3.01 (0.29) 
    3.01 (0.28) 
    0.8747602 
    NA 
    Welch t-test 
    NA 
    TRUE 
    0.8747602 
    0.875 
    Welch t-test 
  
 Pancreatic_polypeptide 
    continuous 
    label 
    Pancreatic polypeptide 
    Pancreatic polypeptide 
    -0.14 (0.67) 
    0.32 (0.74) 
    0.0000008 
    NA 
    Welch t-test 
    NA 
    TRUE 
    0.0000008 
    <0.001 
    Welch t-test 
  
 Prolactin 
    continuous 
    label 
    Prolactin 
    Prolactin 
    0.03 (0.30) 
    0.09 (0.27) 
    0.1059084 
    NA 
    Welch t-test 
    NA 
    TRUE 
    0.1059084 
    0.106 
    Welch t-test 
  
 Prostatic_Acid_Phosphatase 
    continuous 
    label 
    Prostatic acid phosphatase 
    Prostatic acid phosphatase 
    -1.69 (0.06) 
    -1.68 (0.06) 
    0.0631539 
    NA 
    Welch t-test 
    NA 
    TRUE 
    0.0631539 
    0.0632 
    Welch t-test 
  
 Protein_S 
    continuous 
    label 
    Protein S 
    Protein S 
    -2.27 (0.36) 
    -2.17 (0.37) 
    0.0181327 
    NA 
    Welch t-test 
    NA 
    TRUE 
    0.0181327 
    0.0181 
    Welch t-test 
  
 Pulmonary_and_Activation_Regulat 
    continuous 
    label 
    Pulmonary and activation-regulated chemokine 
    Pulmonary and activation-regulated chemokine 
    -1.56 (0.47) 
    -1.47 (0.35) 
    0.1259992 
    NA 
    Welch t-test 
    NA 
    TRUE 
    0.1259992 
    0.126 
    Welch t-test 
  
 RANTES 
    continuous 
    label 
    Regulated on activation, normal T cell expressed and secreted 
    Regulated on activation, normal T cell expressed and secreted 
    -6.55 (0.31) 
    -6.44 (0.31) 
    0.0044494 
    NA 
    Welch t-test 
    NA 
    TRUE 
    0.0044494 
    0.00445 
    Welch t-test 
  
 Resistin 
    continuous 
    label 
    Resistin 
    Resistin 
    -18.52 (5.42) 
    -15.74 (5.93) 
    0.0001487 
    NA 
    Welch t-test 
    NA 
    TRUE 
    0.0001487 
    <0.001 
    Welch t-test 
  
 S100b 
    continuous 
    label 
    S100 calcium-binding protein B 
    S100 calcium-binding protein B 
    1.21 (0.35) 
    1.32 (0.34) 
    0.0078991 
    NA 
    Welch t-test 
    NA 
    TRUE 
    0.0078991 
    0.0079 
    Welch t-test 
  
 SGOT 
    continuous 
    label 
    Serum glutamic-oxaloacetic transaminase 
    Serum glutamic-oxaloacetic transaminase 
    -0.44 (0.37) 
    -0.37 (0.29) 
    0.0469909 
    NA 
    Welch t-test 
    NA 
    TRUE 
    0.0469909 
    0.047 
    Welch t-test 
  
 SHBG 
    continuous 
    label 
    Sex hormone-binding globulin 
    Sex hormone-binding globulin 
    -2.54 (0.57) 
    -2.45 (0.56) 
    0.1686214 
    NA 
    Welch t-test 
    NA 
    TRUE 
    0.1686214 
    0.169 
    Welch t-test 
  
 SOD 
    continuous 
    label 
    Superoxide dismutase 
    Superoxide dismutase 
    5.31 (0.38) 
    5.39 (0.38) 
    0.0833871 
    NA 
    Welch t-test 
    NA 
    TRUE 
    0.0833871 
    0.0834 
    Welch t-test 
  
 Serum_Amyloid_P 
    continuous 
    label 
    Serum amyloid P component 
    Serum amyloid P component 
    -6.05 (0.55) 
    -5.98 (0.57) 
    0.3236618 
    NA 
    Welch t-test 
    NA 
    TRUE 
    0.3236618 
    0.324 
    Welch t-test 
  
 Sortilin 
    continuous 
    label 
    Sortilin 
    Sortilin 
    3.74 (0.86) 
    4.10 (0.83) 
    0.0005339 
    NA 
    Welch t-test 
    NA 
    TRUE 
    0.0005339 
    <0.001 
    Welch t-test 
  
 Stem_Cell_Factor 
    continuous 
    label 
    Stem cell factor 
    Stem cell factor 
    3.30 (0.36) 
    3.28 (0.34) 
    0.6843984 
    NA 
    Welch t-test 
    NA 
    TRUE 
    0.6843984 
    0.684 
    Welch t-test 
  
 TGF_alpha 
    continuous 
    label 
    Transforming growth factor alpha 
    Transforming growth factor alpha 
    9.73 (1.31) 
    9.96 (1.18) 
    0.1283139 
    NA 
    Welch t-test 
    NA 
    TRUE 
    0.1283139 
    0.128 
    Welch t-test 
  
 TIMP_1 
    continuous 
    label 
    Tissue inhibitor of metalloproteinases 1 
    Tissue inhibitor of metalloproteinases 1 
    11.55 (1.78) 
    12.11 (1.97) 
    0.0209928 
    NA 
    Welch t-test 
    NA 
    TRUE 
    0.0209928 
    0.021 
    Welch t-test 
  
 TNF_RII 
    continuous 
    label 
    Tumor necrosis factor receptor II 
    Tumor necrosis factor receptor II 
    -0.64 (0.32) 
    -0.48 (0.35) 
    0.0002205 
    NA 
    Welch t-test 
    NA 
    TRUE 
    0.0002205 
    <0.001 
    Welch t-test 
  
 TRAIL_R3 
    continuous 
    label 
    TNF-related apoptosis-inducing ligand receptor 3 
    TNF-related apoptosis-inducing ligand receptor 3 
    -0.59 (0.23) 
    -0.43 (0.23) 
    0.0000001 
    NA 
    Welch t-test 
    NA 
    TRUE 
    0.0000001 
    <0.001 
    Welch t-test 
  
 TTR_prealbumin 
    continuous 
    label 
    Transthyretin (prealbumin) 
    Transthyretin (prealbumin) 
    2.86 (0.14) 
    2.84 (0.14) 
    0.4396330 
    NA 
    Welch t-test 
    NA 
    TRUE 
    0.4396330 
    0.44 
    Welch t-test 
  
 Tamm_Horsfall_Protein_THP 
    continuous 
    label 
    Tamm-Horsfall protein 
    Tamm-Horsfall protein 
    -3.12 (0.03) 
    -3.11 (0.03) 
    0.3283328 
    NA 
    Welch t-test 
    NA 
    TRUE 
    0.3283328 
    0.328 
    Welch t-test 
  
 Thrombomodulin 
    continuous 
    label 
    Thrombomodulin 
    Thrombomodulin 
    -1.53 (0.23) 
    -1.45 (0.22) 
    0.0028089 
    NA 
    Welch t-test 
    NA 
    TRUE 
    0.0028089 
    0.00281 
    Welch t-test 
  
 Thrombopoietin 
    continuous 
    label 
    Thrombopoietin 
    Thrombopoietin 
    -0.74 (0.24) 
    -0.81 (0.25) 
    0.0630863 
    NA 
    Welch t-test 
    NA 
    TRUE 
    0.0630863 
    0.0631 
    Welch t-test 
  
 Thymus_Expressed_Chemokine_TECK 
    continuous 
    label 
    Thymus-expressed chemokine (TECK) 
    Thymus-expressed chemokine (TECK) 
    3.73 (0.77) 
    4.11 (0.76) 
    0.0000606 
    NA 
    Welch t-test 
    NA 
    TRUE 
    0.0000606 
    <0.001 
    Welch t-test 
  
 Thyroid_Stimulating_Hormone 
    continuous 
    label 
    Thyroid-stimulating hormone 
    Thyroid-stimulating hormone 
    -4.45 (0.75) 
    -4.43 (0.82) 
    0.8817515 
    NA 
    Welch t-test 
    NA 
    TRUE 
    0.8817515 
    0.882 
    Welch t-test 
  
 Thyroxine_Binding_Globulin 
    continuous 
    label 
    Thyroxine-binding globulin 
    Thyroxine-binding globulin 
    -1.51 (0.40) 
    -1.42 (0.39) 
    0.0668355 
    NA 
    Welch t-test 
    NA 
    TRUE 
    0.0668355 
    0.0668 
    Welch t-test 
  
 Tissue_Factor 
    continuous 
    label 
    Tissue factor 
    Tissue factor 
    1.16 (0.51) 
    1.18 (0.51) 
    0.7382965 
    NA 
    Welch t-test 
    NA 
    TRUE 
    0.7382965 
    0.738 
    Welch t-test 
  
 Transferrin 
    continuous 
    label 
    Transferrin 
    Transferrin 
    2.90 (0.28) 
    2.92 (0.27) 
    0.5677089 
    NA 
    Welch t-test 
    NA 
    TRUE 
    0.5677089 
    0.568 
    Welch t-test 
  
 Trefoil_Factor_3_TFF3 
    continuous 
    label 
    Trefoil factor 3 (TFF3) 
    Trefoil factor 3 (TFF3) 
    -3.90 (0.33) 
    -3.85 (0.36) 
    0.2500022 
    NA 
    Welch t-test 
    NA 
    TRUE 
    0.2500022 
    0.25 
    Welch t-test 
  
 VCAM_1 
    continuous 
    label 
    Vascular cell adhesion molecule 1 
    Vascular cell adhesion molecule 1 
    2.66 (0.30) 
    2.73 (0.37) 
    0.0887835 
    NA 
    Welch t-test 
    NA 
    TRUE 
    0.0887835 
    0.0888 
    Welch t-test 
  
 VEGF 
    continuous 
    label 
    Vascular endothelial growth factor 
    Vascular endothelial growth factor 
    17.14 (1.85) 
    16.37 (1.83) 
    0.0008075 
    NA 
    Welch t-test 
    NA 
    TRUE 
    0.0008075 
    <0.001 
    Welch t-test 
  
 Vitronectin 
    continuous 
    label 
    Vitronectin 
    Vitronectin 
    -0.28 (0.33) 
    -0.28 (0.32) 
    0.9569334 
    NA 
    Welch t-test 
    NA 
    TRUE 
    0.9569334 
    0.957 
    Welch t-test 
  
 von_Willebrand_Factor 
    continuous 
    label 
    von Willebrand factor 
    von Willebrand factor 
    -3.95 (0.37) 
    -3.86 (0.39) 
    0.0473700 
    NA 
    Welch t-test 
    NA 
    TRUE 
    0.0473700 
    0.0474 
    Welch t-test 
  
 tau 
    continuous 
    label 
    Tau protein 
    Tau protein 
    5.61 (0.49) 
    6.14 (0.55) 
    0.0000000 
    NA 
    Welch t-test 
    NA 
    TRUE 
    0.0000000 
    <0.001 
    Welch t-test 
  
 p_tau 
    continuous 
    label 
    Phosphorylated tau protein 
    Phosphorylated tau protein 
    3.94 (0.42) 
    4.30 (0.48) 
    0.0000000 
    NA 
    Welch t-test 
    NA 
    TRUE 
    0.0000000 
    <0.001 
    Welch t-test 
  
 Ab_42 
    continuous 
    label 
    Amyloid beta 42 
    Amyloid beta 42 
    12.80 (1.41) 
    11.27 (1.34) 
    0.0000000 
    NA 
    Welch t-test 
    NA 
    TRUE 
    0.0000000 
    <0.001 
    Welch t-test 
  
 age 
    continuous 
    label 
    Age 
    Age 
    72.75 (13.26) 
    71.78 (13.12) 
    0.5526369 
    NA 
    Welch t-test 
    NA 
    TRUE 
    0.5526369 
    0.553 
    Welch t-test 
  
 sex 
    categorical 
    label 
    Sex 
    Sex 
    NA 
    NA 
    0.0272353 
    NA 
    Pearson chi-squared 
    NA 
    TRUE 
    0.0272353 
    0.0272 
    Pearson chi-squared 
  
 sex 
    categorical 
    level 
    Sex 
    Female 
    157 (65%) 
    47 (52%) 
    0.0272353 
    NA 
    Pearson chi-squared 
    NA 
    FALSE 
    0.0272353 
    NA 
    NA 
  
 sex 
    categorical 
    level 
    Sex 
    Male 
    85 (35%) 
    44 (48%) 
    0.0272353 
    NA 
    Pearson chi-squared 
    NA 
    FALSE 
    0.0272353 
    NA 
    NA 
  
 Genotype 
    categorical 
    label 
    Genotype 
    Genotype 
    NA 
    NA 
    0.0005999 
    NA 
    Fisher (sim.) 
    NA 
    TRUE 
    0.0005999 
    <0.001 
    Fisher (sim.) 
  
 Genotype 
    categorical 
    level 
    Genotype 
    E2E2 
    2 (0.8%) 
    0 (0%) 
    0.0005999 
    NA 
    Fisher (sim.) 
    NA 
    FALSE 
    0.0005999 
    NA 
    NA 
  
 Genotype 
    categorical 
    level 
    Genotype 
    E2E3 
    30 (12%) 
    7 (7.7%) 
    0.0005999 
    NA 
    Fisher (sim.) 
    NA 
    FALSE 
    0.0005999 
    NA 
    NA 
  
 Genotype 
    categorical 
    level 
    Genotype 
    E2E4 
    7 (2.9%) 
    1 (1.1%) 
    0.0005999 
    NA 
    Fisher (sim.) 
    NA 
    FALSE 
    0.0005999 
    NA 
    NA 
  
 Genotype 
    categorical 
    level 
    Genotype 
    E3E3 
    133 (55%) 
    34 (37%) 
    0.0005999 
    NA 
    Fisher (sim.) 
    NA 
    FALSE 
    0.0005999 
    NA 
    NA 
  
 Genotype 
    categorical 
    level 
    Genotype 
    E3E4 
    65 (27%) 
    41 (45%) 
    0.0005999 
    NA 
    Fisher (sim.) 
    NA 
    FALSE 
    0.0005999 
    NA 
    NA 
  
 Genotype 
    categorical 
    level 
    Genotype 
    E4E4 
    5 (2.1%) 
    8 (8.8%) 
    0.0005999 
    NA 
    Fisher (sim.) 
    NA 
    FALSE 
    0.0005999 
    NA 
    NA 
  
 ACE_CD143_Angiotensin_Converti 
    continuous 
    label 
    Angiotensin-converting enzyme 
    Angiotensin-converting enzyme 
    1.32 (0.56) 
    1.31 (0.53) 
    0.8846265 
    NA 
    Welch t-test 
    NA 
    TRUE 
    0.8846265 
    0.885 
    Welch t-test 
  
 ACTH_Adrenocorticotropic_Hormon 
    continuous 
    label 
    Adrenocorticotropic hormone 
    Adrenocorticotropic hormone 
    -1.55 (0.27) 
    -1.51 (0.29) 
    0.3228133 
    NA 
    Welch t-test 
    NA 
    TRUE 
    0.3228133 
    0.323 
    Welch t-test 
  
 AXL 
    continuous 
    label 
    AXL receptor tyrosine kinase 
    AXL receptor tyrosine kinase 
    0.28 (0.46) 
    0.34 (0.41) 
    0.2384182 
    NA 
    Welch t-test 
    NA 
    TRUE 
    0.2384182 
    0.238 
    Welch t-test 
  
 Adiponectin 
    continuous 
    label 
    Adiponectin 
    Adiponectin 
    -5.26 (0.65) 
    -5.10 (0.69) 
    0.0538971 
    NA 
    Welch t-test 
    NA 
    TRUE 
    0.0538971 
    0.0539 
    Welch t-test 
  
 Alpha_1_Antichymotrypsin 
    continuous 
    label 
    Alpha-1-antichymotrypsin 
    Alpha-1-antichymotrypsin 
    1.32 (0.36) 
    1.44 (0.37) 
    0.0096393 
    NA 
    Welch t-test 
    NA 
    TRUE 
    0.0096393 
    0.00964 
    Welch t-test 
  
 Alpha_1_Antitrypsin 
    continuous 
    label 
    Alpha-1-antitrypsin 
    Alpha-1-antitrypsin 
    -13.33 (1.51) 
    -12.62 (1.52) 
    0.0001841 
    NA 
    Welch t-test 
    NA 
    TRUE 
    0.0001841 
    <0.001 
    Welch t-test 
  
 Alpha_1_Microglobulin 
    continuous 
    label 
    Alpha-1-microglobulin 
    Alpha-1-microglobulin 
    -2.99 (0.48) 
    -2.82 (0.45) 
    0.0030400 
    NA 
    Welch t-test 
    NA 
    TRUE 
    0.0030400 
    0.00304 
    Welch t-test 
  
 Alpha_2_Macroglobulin 
    continuous 
    label 
    Alpha-2-macroglobulin 
    Alpha-2-macroglobulin 
    -162.49 (41.36) 
    -151.41 (38.78) 
    0.0237020 
    NA 
    Welch t-test 
    NA 
    TRUE 
    0.0237020 
    0.0237 
    Welch t-test 
  
 Angiopoietin_2_ANG_2 
    continuous 
    label 
    Angiopoietin-2 
    Angiopoietin-2 
    0.65 (0.33) 
    0.70 (0.34) 
    0.2243927 
    NA 
    Welch t-test 
    NA 
    TRUE 
    0.2243927 
    0.224 
    Welch t-test 
  
 Angiotensinogen 
    continuous 
    label 
    Angiotensinogen 
    Angiotensinogen 
    2.31 (0.25) 
    2.38 (0.25) 
    0.0363220 
    NA 
    Welch t-test 
    NA 
    TRUE 
    0.0363220 
    0.0363 
    Welch t-test 
  
 Apolipoprotein_A_IV 
    continuous 
    label 
    Apolipoprotein A-IV 
    Apolipoprotein A-IV 
    -1.86 (0.39) 
    -1.84 (0.37) 
    0.6196039 
    NA 
    Welch t-test 
    NA 
    TRUE 
    0.6196039 
    0.62 
    Welch t-test 
  
 Apolipoprotein_A1 
    continuous 
    label 
    Apolipoprotein A-1 
    Apolipoprotein A-1 
    -7.48 (0.43) 
    -7.50 (0.44) 
    0.6901145 
    NA 
    Welch t-test 
    NA 
    TRUE 
    0.6901145 
    0.69 
    Welch t-test 
  
 Apolipoprotein_A2 
    continuous 
    label 
    Apolipoprotein A-2 
    Apolipoprotein A-2 
    -0.66 (0.50) 
    -0.61 (0.48) 
    0.3909281 
    NA 
    Welch t-test 
    NA 
    TRUE 
    0.3909281 
    0.391 
    Welch t-test 
  
 Apolipoprotein_B 
    continuous 
    label 
    Apolipoprotein B 
    Apolipoprotein B 
    -5.71 (1.40) 
    -5.27 (1.55) 
    0.0183210 
    NA 
    Welch t-test 
    NA 
    TRUE 
    0.0183210 
    0.0183 
    Welch t-test 
  
 Apolipoprotein_CI 
    continuous 
    label 
    Apolipoprotein C-I 
    Apolipoprotein C-I 
    -1.60 (0.41) 
    -1.58 (0.45) 
    0.8186647 
    NA 
    Welch t-test 
    NA 
    TRUE 
    0.8186647 
    0.819 
    Welch t-test 
  
 Apolipoprotein_CIII 
    continuous 
    label 
    Apolipoprotein C-III 
    Apolipoprotein C-III 
    -2.53 (0.44) 
    -2.42 (0.44) 
    0.0350373 
    NA 
    Welch t-test 
    NA 
    TRUE 
    0.0350373 
    0.035 
    Welch t-test 
  
 Apolipoprotein_D 
    continuous 
    label 
    Apolipoprotein D 
    Apolipoprotein D 
    1.39 (0.33) 
    1.54 (0.38) 
    0.0015555 
    NA 
    Welch t-test 
    NA 
    TRUE 
    0.0015555 
    0.00156 
    Welch t-test 
  
 Apolipoprotein_E 
    continuous 
    label 
    Apolipoprotein E 
    Apolipoprotein E 
    2.79 (0.77) 
    2.78 (0.87) 
    0.8668217 
    NA 
    Welch t-test 
    NA 
    TRUE 
    0.8668217 
    0.867 
    Welch t-test 
  
 Apolipoprotein_H 
    continuous 
    label 
    Apolipoprotein H 
    Apolipoprotein H 
    -0.35 (0.38) 
    -0.23 (0.38) 
    0.0106232 
    NA 
    Welch t-test 
    NA 
    TRUE 
    0.0106232 
    0.0106 
    Welch t-test 
  
 B_Lymphocyte_Chemoattractant_BL 
    continuous 
    label 
    B-lymphocyte chemoattractant 
    B-lymphocyte chemoattractant 
    1.92 (0.57) 
    2.16 (0.56) 
    0.0007177 
    NA 
    Welch t-test 
    NA 
    TRUE 
    0.0007177 
    <0.001 
    Welch t-test 
  
 BMP_6 
    continuous 
    label 
    Bone morphogenetic protein 6 
    Bone morphogenetic protein 6 
    -1.89 (0.29) 
    -1.92 (0.33) 
    0.5218752 
    NA 
    Welch t-test 
    NA 
    TRUE 
    0.5218752 
    0.522 
    Welch t-test 
  
 Beta_2_Microglobulin 
    continuous 
    label 
    Beta-2-microglobulin 
    Beta-2-microglobulin 
    0.16 (0.29) 
    0.19 (0.31) 
    0.4233981 
    NA 
    Welch t-test 
    NA 
    TRUE 
    0.4233981 
    0.423 
    Welch t-test 
  
 Betacellulin 
    continuous 
    label 
    Betacellulin 
    Betacellulin 
    51.63 (10.91) 
    50.62 (10.60) 
    0.4399492 
    NA 
    Welch t-test 
    NA 
    TRUE 
    0.4399492 
    0.44 
    Welch t-test 
  
 C_Reactive_Protein 
    continuous 
    label 
    C-reactive protein 
    C-reactive protein 
    -5.87 (1.22) 
    -5.97 (1.14) 
    0.4843525 
    NA 
    Welch t-test 
    NA 
    TRUE 
    0.4843525 
    0.484 
    Welch t-test 
  
 CD40 
    continuous 
    label 
    CD40 
    CD40 
    -1.26 (0.21) 
    -1.28 (0.24) 
    0.5003297 
    NA 
    Welch t-test 
    NA 
    TRUE 
    0.5003297 
    0.5 
    Welch t-test 
  
 CD5L 
    continuous 
    label 
    CD5L 
    CD5L 
    -0.10 (0.44) 
    0.04 (0.49) 
    0.0247260 
    NA 
    Welch t-test 
    NA 
    TRUE 
    0.0247260 
    0.0247 
    Welch t-test 
  
 Calbindin 
    continuous 
    label 
    Calbindin 
    Calbindin 
    21.99 (3.90) 
    22.93 (4.85) 
    0.1011017 
    NA 
    Welch t-test 
    NA 
    TRUE 
    0.1011017 
    0.101 
    Welch t-test 
  
 Calcitonin 
    continuous 
    label 
    Calcitonin 
    Calcitonin 
    1.68 (0.85) 
    1.71 (0.94) 
    0.7808643 
    NA 
    Welch t-test 
    NA 
    TRUE 
    0.7808643 
    0.781 
    Welch t-test 
  
 CgA 
    continuous 
    label 
    Chromogranin A 
    Chromogranin A 
    329.78 (82.65) 
    333.17 (81.12) 
    0.7351867 
    NA 
    Welch t-test 
    NA 
    TRUE 
    0.7351867 
    0.735 
    Welch t-test 
  
 Clusterin_Apo_J 
    continuous 
    label 
    Clusterin (ApoJ) 
    Clusterin (ApoJ) 
    2.85 (0.29) 
    2.95 (0.33) 
    0.0116372 
    NA 
    Welch t-test 
    NA 
    TRUE 
    0.0116372 
    0.0116 
    Welch t-test 
  
 Complement_3 
    continuous 
    label 
    Complement component 3 
    Complement component 3 
    -15.95 (2.45) 
    -14.92 (2.43) 
    0.0007632 
    NA 
    Welch t-test 
    NA 
    TRUE 
    0.0007632 
    <0.001 
    Welch t-test 
  
 Complement_Factor_H 
    continuous 
    label 
    Complement factor H 
    Complement factor H 
    3.48 (1.26) 
    3.62 (1.22) 
    0.3580892 
    NA 
    Welch t-test 
    NA 
    TRUE 
    0.3580892 
    0.358 
    Welch t-test 
  
 Connective_Tissue_Growth_Factor 
    continuous 
    label 
    Connective tissue growth factor 
    Connective tissue growth factor 
    0.76 (0.21) 
    0.79 (0.20) 
    0.2752610 
    NA 
    Welch t-test 
    NA 
    TRUE 
    0.2752610 
    0.275 
    Welch t-test 
  
 Cortisol 
    continuous 
    label 
    Cortisol 
    Cortisol 
    11.22 (3.73) 
    12.93 (4.34) 
    0.0011179 
    NA 
    Welch t-test 
    NA 
    TRUE 
    0.0011179 
    0.00112 
    Welch t-test 
  
 Creatine_Kinase_MB 
    continuous 
    label 
    Creatine kinase-MB 
    Creatine kinase-MB 
    -1.66 (0.10) 
    -1.70 (0.08) 
    0.0001039 
    NA 
    Welch t-test 
    NA 
    TRUE 
    0.0001039 
    <0.001 
    Welch t-test 
  
 Cystatin_C 
    continuous 
    label 
    Cystatin C 
    Cystatin C 
    8.62 (0.40) 
    8.48 (0.40) 
    0.0055073 
    NA 
    Welch t-test 
    NA 
    TRUE 
    0.0055073 
    0.00551 
    Welch t-test 
  
 EGF_R 
    continuous 
    label 
    Epidermal growth factor receptor 
    Epidermal growth factor receptor 
    -0.71 (0.24) 
    -0.68 (0.22) 
    0.4379144 
    NA 
    Welch t-test 
    NA 
    TRUE 
    0.4379144 
    0.438 
    Welch t-test 
  
 EN_RAGE 
    continuous 
    label 
    EN-RAGE (extracellular newly identified RAGE-binding protein) 
    EN-RAGE (extracellular newly identified RAGE-binding protein) 
    -3.62 (0.90) 
    -3.65 (0.88) 
    0.7659387 
    NA 
    Welch t-test 
    NA 
    TRUE 
    0.7659387 
    0.766 
    Welch t-test 
  
 ENA_78 
    continuous 
    label 
    ENA-78 (epithelial-derived neutrophil-activating protein 78) 
    ENA-78 (epithelial-derived neutrophil-activating protein 78) 
    -1.37 (0.01) 
    -1.37 (0.01) 
    0.9254390 
    NA 
    Welch t-test 
    NA 
    TRUE 
    0.9254390 
    0.925 
    Welch t-test 
  
 Eotaxin_3 
    continuous 
    label 
    Eotaxin-3 
    Eotaxin-3 
    55.36 (15.98) 
    63.75 (15.86) 
    0.0000303 
    NA 
    Welch t-test 
    NA 
    TRUE 
    0.0000303 
    <0.001 
    Welch t-test 
  
 FAS 
    continuous 
    label 
    Fas (tumor necrosis factor receptor superfamily member 6) 
    Fas (tumor necrosis factor receptor superfamily member 6) 
    -0.58 (0.28) 
    -0.40 (0.31) 
    0.0000019 
    NA 
    Welch t-test 
    NA 
    TRUE 
    0.0000019 
    <0.001 
    Welch t-test 
  
 FSH_Follicle_Stimulation_Hormon 
    continuous 
    label 
    Follicle-stimulating hormone 
    Follicle-stimulating hormone 
    -1.12 (0.39) 
    -1.15 (0.43) 
    0.6164374 
    NA 
    Welch t-test 
    NA 
    TRUE 
    0.6164374 
    0.616 
    Welch t-test 
  
 Fas_Ligand 
    continuous 
    label 
    Fas ligand 
    Fas ligand 
    2.79 (1.05) 
    3.22 (1.12) 
    0.0015514 
    NA 
    Welch t-test 
    NA 
    TRUE 
    0.0015514 
    0.00155 
    Welch t-test 
  
 Fatty_Acid_Binding_Protein 
    continuous 
    label 
    Fatty acid-binding protein 
    Fatty acid-binding protein 
    1.24 (0.73) 
    1.59 (0.86) 
    0.0007710 
    NA 
    Welch t-test 
    NA 
    TRUE 
    0.0007710 
    <0.001 
    Welch t-test 
  
 Ferritin 
    continuous 
    label 
    Ferritin 
    Ferritin 
    2.70 (0.76) 
    2.90 (0.83) 
    0.0426440 
    NA 
    Welch t-test 
    NA 
    TRUE 
    0.0426440 
    0.0426 
    Welch t-test 
  
 Fetuin_A 
    continuous 
    label 
    Fetuin-A 
    Fetuin-A 
    1.32 (0.40) 
    1.44 (0.34) 
    0.0314522 
    NA 
    Welch t-test 
    NA 
    TRUE 
    0.0314522 
    0.0315 
    Welch t-test 
  
 Fibrinogen 
    continuous 
    label 
    Fibrinogen 
    Fibrinogen 
    -7.45 (0.56) 
    -7.12 (0.57) 
    0.0000075 
    NA 
    Welch t-test 
    NA 
    TRUE 
    0.0000075 
    <0.001 
    Welch t-test 
  
 GRO_alpha 
    continuous 
    label 
    Growth-regulated alpha protein 
    Growth-regulated alpha protein 
    1.37 (0.04) 
    1.40 (0.04) 
    0.0000000 
    NA 
    Welch t-test 
    NA 
    TRUE 
    0.0000000 
    <0.001 
    Welch t-test 
  
 Gamma_Interferon_induced_Monokin 
    continuous 
    label 
    Gamma interferon-induced monokine 
    Gamma interferon-induced monokine 
    2.77 (0.11) 
    2.83 (0.10) 
    0.0000059 
    NA 
    Welch t-test 
    NA 
    TRUE 
    0.0000059 
    <0.001 
    Welch t-test 
  
 Glutathione_S_Transferase_alpha 
    continuous 
    label 
    Glutathione S-transferase alpha 
    Glutathione S-transferase alpha 
    0.95 (0.17) 
    0.96 (0.12) 
    0.5459600 
    NA 
    Welch t-test 
    NA 
    TRUE 
    0.5459600 
    0.546 
    Welch t-test 
  
 HB_EGF 
    continuous 
    label 
    Heparin-binding epidermal growth factor 
    Heparin-binding epidermal growth factor 
    6.70 (1.47) 
    7.20 (1.49) 
    0.0061319 
    NA 
    Welch t-test 
    NA 
    TRUE 
    0.0061319 
    0.00613 
    Welch t-test 
  
 HCC_4 
    continuous 
    label 
    HCC-4 (hemofiltrate CC chemokine-4) 
    HCC-4 (hemofiltrate CC chemokine-4) 
    -3.55 (0.36) 
    -3.40 (0.34) 
    0.0005695 
    NA 
    Welch t-test 
    NA 
    TRUE 
    0.0005695 
    <0.001 
    Welch t-test 
  
 Hepatocyte_Growth_Factor_HGF 
    continuous 
    label 
    Hepatocyte growth factor 
    Hepatocyte growth factor 
    0.17 (0.29) 
    0.27 (0.29) 
    0.0051215 
    NA 
    Welch t-test 
    NA 
    TRUE 
    0.0051215 
    0.00512 
    Welch t-test 
  
 I_309 
    continuous 
    label 
    I-309 (TCA-3) 
    I-309 (TCA-3) 
    2.92 (0.36) 
    3.02 (0.39) 
    0.0337660 
    NA 
    Welch t-test 
    NA 
    TRUE 
    0.0337660 
    0.0338 
    Welch t-test 
  
 ICAM_1 
    continuous 
    label 
    Intercellular adhesion molecule 1 
    Intercellular adhesion molecule 1 
    -0.60 (0.32) 
    -0.56 (0.36) 
    0.3368872 
    NA 
    Welch t-test 
    NA 
    TRUE 
    0.3368872 
    0.337 
    Welch t-test 
  
 IGF_BP_2 
    continuous 
    label 
    Insulin-like growth factor-binding protein 2 
    Insulin-like growth factor-binding protein 2 
    5.28 (0.20) 
    5.38 (0.22) 
    0.0001243 
    NA 
    Welch t-test 
    NA 
    TRUE 
    0.0001243 
    <0.001 
    Welch t-test 
  
 IL_11 
    continuous 
    label 
    Interleukin 11 
    Interleukin 11 
    4.73 (1.39) 
    4.65 (1.53) 
    0.6424064 
    NA 
    Welch t-test 
    NA 
    TRUE 
    0.6424064 
    0.642 
    Welch t-test 
  
 IL_13 
    continuous 
    label 
    Interleukin 13 
    Interleukin 13 
    1.28 (0.01) 
    1.28 (0.01) 
    0.2577007 
    NA 
    Welch t-test 
    NA 
    TRUE 
    0.2577007 
    0.258 
    Welch t-test 
  
 IL_16 
    continuous 
    label 
    Interleukin 16 
    Interleukin 16 
    2.91 (0.67) 
    2.91 (0.65) 
    0.9601492 
    NA 
    Welch t-test 
    NA 
    TRUE 
    0.9601492 
    0.96 
    Welch t-test 
  
 IL_17E 
    continuous 
    label 
    Interleukin 17E 
    Interleukin 17E 
    4.95 (1.41) 
    4.55 (1.07) 
    0.0057222 
    NA 
    Welch t-test 
    NA 
    TRUE 
    0.0057222 
    0.00572 
    Welch t-test 
  
 IL_1alpha 
    continuous 
    label 
    Interleukin 1 alpha 
    Interleukin 1 alpha 
    -7.54 (0.39) 
    -7.48 (0.43) 
    0.3035679 
    NA 
    Welch t-test 
    NA 
    TRUE 
    0.3035679 
    0.304 
    Welch t-test 
  
 IL_3 
    continuous 
    label 
    Interleukin 3 
    Interleukin 3 
    -3.93 (0.51) 
    -3.99 (0.50) 
    0.4067009 
    NA 
    Welch t-test 
    NA 
    TRUE 
    0.4067009 
    0.407 
    Welch t-test 
  
 IL_4 
    continuous 
    label 
    Interleukin 4 
    Interleukin 4 
    1.78 (0.50) 
    1.72 (0.53) 
    0.3623877 
    NA 
    Welch t-test 
    NA 
    TRUE 
    0.3623877 
    0.362 
    Welch t-test 
  
 IL_5 
    continuous 
    label 
    Interleukin 5 
    Interleukin 5 
    0.21 (0.46) 
    0.17 (0.44) 
    0.4598690 
    NA 
    Welch t-test 
    NA 
    TRUE 
    0.4598690 
    0.46 
    Welch t-test 
  
 IL_6 
    continuous 
    label 
    Interleukin 6 
    Interleukin 6 
    -0.15 (0.51) 
    -0.14 (0.62) 
    0.9841252 
    NA 
    Welch t-test 
    NA 
    TRUE 
    0.9841252 
    0.984 
    Welch t-test 
  
 IL_6_Receptor 
    continuous 
    label 
    Interleukin 6 receptor 
    Interleukin 6 receptor 
    0.09 (0.32) 
    0.08 (0.34) 
    0.8068581 
    NA 
    Welch t-test 
    NA 
    TRUE 
    0.8068581 
    0.807 
    Welch t-test 
  
 IL_7 
    continuous 
    label 
    Interleukin 7 
    Interleukin 7 
    3.01 (0.99) 
    2.61 (1.04) 
    0.0017584 
    NA 
    Welch t-test 
    NA 
    TRUE 
    0.0017584 
    0.00176 
    Welch t-test 
  
 IL_8 
    continuous 
    label 
    Interleukin 8 
    Interleukin 8 
    1.70 (0.03) 
    1.71 (0.04) 
    0.0318468 
    NA 
    Welch t-test 
    NA 
    TRUE 
    0.0318468 
    0.0318 
    Welch t-test 
  
 IP_10_Inducible_Protein_10 
    continuous 
    label 
    Inducible protein 10 
    Inducible protein 10 
    5.69 (0.51) 
    5.85 (0.48) 
    0.0084555 
    NA 
    Welch t-test 
    NA 
    TRUE 
    0.0084555 
    0.00846 
    Welch t-test 
  
 IgA 
    continuous 
    label 
    Immunoglobulin A 
    Immunoglobulin A 
    -6.17 (0.75) 
    -5.94 (0.69) 
    0.0078162 
    NA 
    Welch t-test 
    NA 
    TRUE 
    0.0078162 
    0.00782 
    Welch t-test 
  
 Insulin 
    continuous 
    label 
    Insulin 
    Insulin 
    -1.21 (0.33) 
    -1.26 (0.36) 
    0.2895756 
    NA 
    Welch t-test 
    NA 
    TRUE 
    0.2895756 
    0.29 
    Welch t-test 
  
 Kidney_Injury_Molecule_1_KIM_1 
    continuous 
    label 
    Kidney injury molecule 1 
    Kidney injury molecule 1 
    -1.19 (0.03) 
    -1.18 (0.02) 
    0.0048740 
    NA 
    Welch t-test 
    NA 
    TRUE 
    0.0048740 
    0.00487 
    Welch t-test 
  
 LOX_1 
    continuous 
    label 
    Lectin-like oxidized LDL receptor 1 
    Lectin-like oxidized LDL receptor 1 
    1.27 (0.40) 
    1.27 (0.45) 
    0.9876103 
    NA 
    Welch t-test 
    NA 
    TRUE 
    0.9876103 
    0.988 
    Welch t-test 
  
 Leptin 
    continuous 
    label 
    Leptin 
    Leptin 
    -1.48 (0.27) 
    -1.53 (0.26) 
    0.0940108 
    NA 
    Welch t-test 
    NA 
    TRUE 
    0.0940108 
    0.094 
    Welch t-test 
  
 Lipoprotein_a 
    continuous 
    label 
    Lipoprotein(a) 
    Lipoprotein(a) 
    -4.51 (1.03) 
    -4.25 (1.16) 
    0.0629993 
    NA 
    Welch t-test 
    NA 
    TRUE 
    0.0629993 
    0.063 
    Welch t-test 
  
 MCP_1 
    continuous 
    label 
    Monocyte chemoattractant protein 1 
    Monocyte chemoattractant protein 1 
    6.48 (0.26) 
    6.52 (0.25) 
    0.1775721 
    NA 
    Welch t-test 
    NA 
    TRUE 
    0.1775721 
    0.178 
    Welch t-test 
  
 MCP_2 
    continuous 
    label 
    Monocyte chemoattractant protein 2 
    Monocyte chemoattractant protein 2 
    1.78 (0.62) 
    2.07 (0.64) 
    0.0002487 
    NA 
    Welch t-test 
    NA 
    TRUE 
    0.0002487 
    <0.001 
    Welch t-test 
  
 MIF 
    continuous 
    label 
    Macrophage migration inhibitory factor 
    Macrophage migration inhibitory factor 
    -1.93 (0.33) 
    -1.74 (0.29) 
    0.0000004 
    NA 
    Welch t-test 
    NA 
    TRUE 
    0.0000004 
    <0.001 
    Welch t-test 
  
 MIP_1alpha 
    continuous 
    label 
    Macrophage inflammatory protein 1 alpha 
    Macrophage inflammatory protein 1 alpha 
    3.94 (1.05) 
    4.24 (0.88) 
    0.0083499 
    NA 
    Welch t-test 
    NA 
    TRUE 
    0.0083499 
    0.00835 
    Welch t-test 
  
 MIP_1beta 
    continuous 
    label 
    Macrophage inflammatory protein 1 beta 
    Macrophage inflammatory protein 1 beta 
    2.79 (0.38) 
    2.87 (0.40) 
    0.0869483 
    NA 
    Welch t-test 
    NA 
    TRUE 
    0.0869483 
    0.0869 
    Welch t-test 
  
 MMP_2 
    continuous 
    label 
    Matrix metalloproteinase 2 
    Matrix metalloproteinase 2 
    2.95 (0.95) 
    2.81 (0.89) 
    0.2122963 
    NA 
    Welch t-test 
    NA 
    TRUE 
    0.2122963 
    0.212 
    Welch t-test 
  
 MMP_3 
    continuous 
    label 
    Matrix metalloproteinase 3 
    Matrix metalloproteinase 3 
    -2.49 (0.56) 
    -2.36 (0.60) 
    0.0738423 
    NA 
    Welch t-test 
    NA 
    TRUE 
    0.0738423 
    0.0738 
    Welch t-test 
  
 MMP10 
    continuous 
    label 
    Matrix metalloproteinase 10 
    Matrix metalloproteinase 10 
    -3.73 (0.40) 
    -3.42 (0.44) 
    0.0000000 
    NA 
    Welch t-test 
    NA 
    TRUE 
    0.0000000 
    <0.001 
    Welch t-test 
  
 MMP7 
    continuous 
    label 
    Matrix metalloproteinase 7 
    Matrix metalloproteinase 7 
    -4.07 (1.58) 
    -3.21 (1.28) 
    0.0000009 
    NA 
    Welch t-test 
    NA 
    TRUE 
    0.0000009 
    <0.001 
    Welch t-test 
  
 Myoglobin 
    continuous 
    label 
    Myoglobin 
    Myoglobin 
    -1.43 (0.96) 
    -1.23 (0.87) 
    0.0755465 
    NA 
    Welch t-test 
    NA 
    TRUE 
    0.0755465 
    0.0755 
    Welch t-test 
  
 NT_proBNP 
    continuous 
    label 
    N-terminal pro b-type natriuretic peptide 
    N-terminal pro b-type natriuretic peptide 
    4.46 (0.36) 
    4.71 (0.36) 
    0.0000038 
    NA 
    Welch t-test 
    NA 
    TRUE 
    0.0000038 
    <0.001 
    Welch t-test 
  
 NrCAM 
    continuous 
    label 
    Neuron-glia cell adhesion molecule 
    Neuron-glia cell adhesion molecule 
    4.38 (0.56) 
    4.33 (0.54) 
    0.5219452 
    NA 
    Welch t-test 
    NA 
    TRUE 
    0.5219452 
    0.522 
    Welch t-test 
  
 Osteopontin 
    continuous 
    label 
    Osteopontin 
    Osteopontin 
    5.16 (0.38) 
    5.31 (0.41) 
    0.0022081 
    NA 
    Welch t-test 
    NA 
    TRUE 
    0.0022081 
    0.00221 
    Welch t-test 
  
 PAI_1 
    continuous 
    label 
    Plasminogen activator inhibitor 1 
    Plasminogen activator inhibitor 1 
    -0.01 (0.38) 
    0.26 (0.44) 
    0.0000007 
    NA 
    Welch t-test 
    NA 
    TRUE 
    0.0000007 
    <0.001 
    Welch t-test 
  
 PAPP_A 
    continuous 
    label 
    Pregnancy-associated plasma protein A 
    Pregnancy-associated plasma protein A 
    -2.85 (0.14) 
    -2.85 (0.14) 
    0.9612735 
    NA 
    Welch t-test 
    NA 
    TRUE 
    0.9612735 
    0.961 
    Welch t-test 
  
 PLGF 
    continuous 
    label 
    Placental growth factor 
    Placental growth factor 
    3.87 (0.39) 
    4.01 (0.42) 
    0.0045508 
    NA 
    Welch t-test 
    NA 
    TRUE 
    0.0045508 
    0.00455 
    Welch t-test 
  
 PYY 
    continuous 
    label 
    Peptide YY 
    Peptide YY 
    3.01 (0.29) 
    3.01 (0.28) 
    0.8747602 
    NA 
    Welch t-test 
    NA 
    TRUE 
    0.8747602 
    0.875 
    Welch t-test 
  
 Pancreatic_polypeptide 
    continuous 
    label 
    Pancreatic polypeptide 
    Pancreatic polypeptide 
    -0.14 (0.67) 
    0.32 (0.74) 
    0.0000008 
    NA 
    Welch t-test 
    NA 
    TRUE 
    0.0000008 
    <0.001 
    Welch t-test 
  
 Prolactin 
    continuous 
    label 
    Prolactin 
    Prolactin 
    0.03 (0.30) 
    0.09 (0.27) 
    0.1059084 
    NA 
    Welch t-test 
    NA 
    TRUE 
    0.1059084 
    0.106 
    Welch t-test 
  
 Prostatic_Acid_Phosphatase 
    continuous 
    label 
    Prostatic acid phosphatase 
    Prostatic acid phosphatase 
    -1.69 (0.06) 
    -1.68 (0.06) 
    0.0631539 
    NA 
    Welch t-test 
    NA 
    TRUE 
    0.0631539 
    0.0632 
    Welch t-test 
  
 Protein_S 
    continuous 
    label 
    Protein S 
    Protein S 
    -2.27 (0.36) 
    -2.17 (0.37) 
    0.0181327 
    NA 
    Welch t-test 
    NA 
    TRUE 
    0.0181327 
    0.0181 
    Welch t-test 
  
 Pulmonary_and_Activation_Regulat 
    continuous 
    label 
    Pulmonary and activation-regulated chemokine 
    Pulmonary and activation-regulated chemokine 
    -1.56 (0.47) 
    -1.47 (0.35) 
    0.1259992 
    NA 
    Welch t-test 
    NA 
    TRUE 
    0.1259992 
    0.126 
    Welch t-test 
  
 RANTES 
    continuous 
    label 
    Regulated on activation, normal T cell expressed and secreted 
    Regulated on activation, normal T cell expressed and secreted 
    -6.55 (0.31) 
    -6.44 (0.31) 
    0.0044494 
    NA 
    Welch t-test 
    NA 
    TRUE 
    0.0044494 
    0.00445 
    Welch t-test 
  
 Resistin 
    continuous 
    label 
    Resistin 
    Resistin 
    -18.52 (5.42) 
    -15.74 (5.93) 
    0.0001487 
    NA 
    Welch t-test 
    NA 
    TRUE 
    0.0001487 
    <0.001 
    Welch t-test 
  
 S100b 
    continuous 
    label 
    S100 calcium-binding protein B 
    S100 calcium-binding protein B 
    1.21 (0.35) 
    1.32 (0.34) 
    0.0078991 
    NA 
    Welch t-test 
    NA 
    TRUE 
    0.0078991 
    0.0079 
    Welch t-test 
  
 SGOT 
    continuous 
    label 
    Serum glutamic-oxaloacetic transaminase 
    Serum glutamic-oxaloacetic transaminase 
    -0.44 (0.37) 
    -0.37 (0.29) 
    0.0469909 
    NA 
    Welch t-test 
    NA 
    TRUE 
    0.0469909 
    0.047 
    Welch t-test 
  
 SHBG 
    continuous 
    label 
    Sex hormone-binding globulin 
    Sex hormone-binding globulin 
    -2.54 (0.57) 
    -2.45 (0.56) 
    0.1686214 
    NA 
    Welch t-test 
    NA 
    TRUE 
    0.1686214 
    0.169 
    Welch t-test 
  
 SOD 
    continuous 
    label 
    Superoxide dismutase 
    Superoxide dismutase 
    5.31 (0.38) 
    5.39 (0.38) 
    0.0833871 
    NA 
    Welch t-test 
    NA 
    TRUE 
    0.0833871 
    0.0834 
    Welch t-test 
  
 Serum_Amyloid_P 
    continuous 
    label 
    Serum amyloid P component 
    Serum amyloid P component 
    -6.05 (0.55) 
    -5.98 (0.57) 
    0.3236618 
    NA 
    Welch t-test 
    NA 
    TRUE 
    0.3236618 
    0.324 
    Welch t-test 
  
 Sortilin 
    continuous 
    label 
    Sortilin 
    Sortilin 
    3.74 (0.86) 
    4.10 (0.83) 
    0.0005339 
    NA 
    Welch t-test 
    NA 
    TRUE 
    0.0005339 
    <0.001 
    Welch t-test 
  
 Stem_Cell_Factor 
    continuous 
    label 
    Stem cell factor 
    Stem cell factor 
    3.30 (0.36) 
    3.28 (0.34) 
    0.6843984 
    NA 
    Welch t-test 
    NA 
    TRUE 
    0.6843984 
    0.684 
    Welch t-test 
  
 TGF_alpha 
    continuous 
    label 
    Transforming growth factor alpha 
    Transforming growth factor alpha 
    9.73 (1.31) 
    9.96 (1.18) 
    0.1283139 
    NA 
    Welch t-test 
    NA 
    TRUE 
    0.1283139 
    0.128 
    Welch t-test 
  
 TIMP_1 
    continuous 
    label 
    Tissue inhibitor of metalloproteinases 1 
    Tissue inhibitor of metalloproteinases 1 
    11.55 (1.78) 
    12.11 (1.97) 
    0.0209928 
    NA 
    Welch t-test 
    NA 
    TRUE 
    0.0209928 
    0.021 
    Welch t-test 
  
 TNF_RII 
    continuous 
    label 
    Tumor necrosis factor receptor II 
    Tumor necrosis factor receptor II 
    -0.64 (0.32) 
    -0.48 (0.35) 
    0.0002205 
    NA 
    Welch t-test 
    NA 
    TRUE 
    0.0002205 
    <0.001 
    Welch t-test 
  
 TRAIL_R3 
    continuous 
    label 
    TNF-related apoptosis-inducing ligand receptor 3 
    TNF-related apoptosis-inducing ligand receptor 3 
    -0.59 (0.23) 
    -0.43 (0.23) 
    0.0000001 
    NA 
    Welch t-test 
    NA 
    TRUE 
    0.0000001 
    <0.001 
    Welch t-test 
  
 TTR_prealbumin 
    continuous 
    label 
    Transthyretin (prealbumin) 
    Transthyretin (prealbumin) 
    2.86 (0.14) 
    2.84 (0.14) 
    0.4396330 
    NA 
    Welch t-test 
    NA 
    TRUE 
    0.4396330 
    0.44 
    Welch t-test 
  
 Tamm_Horsfall_Protein_THP 
    continuous 
    label 
    Tamm-Horsfall protein 
    Tamm-Horsfall protein 
    -3.12 (0.03) 
    -3.11 (0.03) 
    0.3283328 
    NA 
    Welch t-test 
    NA 
    TRUE 
    0.3283328 
    0.328 
    Welch t-test 
  
 Thrombomodulin 
    continuous 
    label 
    Thrombomodulin 
    Thrombomodulin 
    -1.53 (0.23) 
    -1.45 (0.22) 
    0.0028089 
    NA 
    Welch t-test 
    NA 
    TRUE 
    0.0028089 
    0.00281 
    Welch t-test 
  
 Thrombopoietin 
    continuous 
    label 
    Thrombopoietin 
    Thrombopoietin 
    -0.74 (0.24) 
    -0.81 (0.25) 
    0.0630863 
    NA 
    Welch t-test 
    NA 
    TRUE 
    0.0630863 
    0.0631 
    Welch t-test 
  
 Thymus_Expressed_Chemokine_TECK 
    continuous 
    label 
    Thymus-expressed chemokine (TECK) 
    Thymus-expressed chemokine (TECK) 
    3.73 (0.77) 
    4.11 (0.76) 
    0.0000606 
    NA 
    Welch t-test 
    NA 
    TRUE 
    0.0000606 
    <0.001 
    Welch t-test 
  
 Thyroid_Stimulating_Hormone 
    continuous 
    label 
    Thyroid-stimulating hormone 
    Thyroid-stimulating hormone 
    -4.45 (0.75) 
    -4.43 (0.82) 
    0.8817515 
    NA 
    Welch t-test 
    NA 
    TRUE 
    0.8817515 
    0.882 
    Welch t-test 
  
 Thyroxine_Binding_Globulin 
    continuous 
    label 
    Thyroxine-binding globulin 
    Thyroxine-binding globulin 
    -1.51 (0.40) 
    -1.42 (0.39) 
    0.0668355 
    NA 
    Welch t-test 
    NA 
    TRUE 
    0.0668355 
    0.0668 
    Welch t-test 
  
 Tissue_Factor 
    continuous 
    label 
    Tissue factor 
    Tissue factor 
    1.16 (0.51) 
    1.18 (0.51) 
    0.7382965 
    NA 
    Welch t-test 
    NA 
    TRUE 
    0.7382965 
    0.738 
    Welch t-test 
  
 Transferrin 
    continuous 
    label 
    Transferrin 
    Transferrin 
    2.90 (0.28) 
    2.92 (0.27) 
    0.5677089 
    NA 
    Welch t-test 
    NA 
    TRUE 
    0.5677089 
    0.568 
    Welch t-test 
  
 Trefoil_Factor_3_TFF3 
    continuous 
    label 
    Trefoil factor 3 (TFF3) 
    Trefoil factor 3 (TFF3) 
    -3.90 (0.33) 
    -3.85 (0.36) 
    0.2500022 
    NA 
    Welch t-test 
    NA 
    TRUE 
    0.2500022 
    0.25 
    Welch t-test 
  
 VCAM_1 
    continuous 
    label 
    Vascular cell adhesion molecule 1 
    Vascular cell adhesion molecule 1 
    2.66 (0.30) 
    2.73 (0.37) 
    0.0887835 
    NA 
    Welch t-test 
    NA 
    TRUE 
    0.0887835 
    0.0888 
    Welch t-test 
  
 VEGF 
    continuous 
    label 
    Vascular endothelial growth factor 
    Vascular endothelial growth factor 
    17.14 (1.85) 
    16.37 (1.83) 
    0.0008075 
    NA 
    Welch t-test 
    NA 
    TRUE 
    0.0008075 
    <0.001 
    Welch t-test 
  
 Vitronectin 
    continuous 
    label 
    Vitronectin 
    Vitronectin 
    -0.28 (0.33) 
    -0.28 (0.32) 
    0.9569334 
    NA 
    Welch t-test 
    NA 
    TRUE 
    0.9569334 
    0.957 
    Welch t-test 
  
 von_Willebrand_Factor 
    continuous 
    label 
    von Willebrand factor 
    von Willebrand factor 
    -3.95 (0.37) 
    -3.86 (0.39) 
    0.0473700 
    NA 
    Welch t-test 
    NA 
    TRUE 
    0.0473700 
    0.0474 
    Welch t-test 
  
 tau 
    continuous 
    label 
    Tau protein 
    Tau protein 
    5.61 (0.49) 
    6.14 (0.55) 
    0.0000000 
    NA 
    Welch t-test 
    NA 
    TRUE 
    0.0000000 
    <0.001 
    Welch t-test 
  
 p_tau 
    continuous 
    label 
    Phosphorylated tau protein 
    Phosphorylated tau protein 
    3.94 (0.42) 
    4.30 (0.48) 
    0.0000000 
    NA 
    Welch t-test 
    NA 
    TRUE 
    0.0000000 
    <0.001 
    Welch t-test 
  
 Ab_42 
    continuous 
    label 
    Amyloid beta 42 
    Amyloid beta 42 
    12.80 (1.41) 
    11.27 (1.34) 
    0.0000000 
    NA 
    Welch t-test 
    NA 
    TRUE 
    0.0000000 
    <0.001 
    Welch t-test 
  
 age 
    continuous 
    label 
    Age 
    Age 
    72.75 (13.26) 
    71.78 (13.12) 
    0.5526369 
    NA 
    Welch t-test 
    NA 
    TRUE 
    0.5526369 
    0.553 
    Welch t-test 
  
 sex 
    categorical 
    label 
    Sex 
    Sex 
    NA 
    NA 
    0.0272353 
    NA 
    Pearson chi-squared 
    NA 
    TRUE 
    0.0272353 
    0.0272 
    Pearson chi-squared 
  
 sex 
    categorical 
    level 
    Sex 
    Female 
    157 (65%) 
    47 (52%) 
    0.0272353 
    NA 
    Pearson chi-squared 
    NA 
    FALSE 
    0.0272353 
    NA 
    NA 
  
 sex 
    categorical 
    level 
    Sex 
    Male 
    85 (35%) 
    44 (48%) 
    0.0272353 
    NA 
    Pearson chi-squared 
    NA 
    FALSE 
    0.0272353 
    NA 
    NA 
  
 Genotype 
    categorical 
    label 
    Genotype 
    Genotype 
    NA 
    NA 
    0.0005999 
    NA 
    Fisher (sim.) 
    NA 
    TRUE 
    0.0005999 
    <0.001 
    Fisher (sim.) 
  
 Genotype 
    categorical 
    level 
    Genotype 
    E2E2 
    2 (0.8%) 
    0 (0%) 
    0.0005999 
    NA 
    Fisher (sim.) 
    NA 
    FALSE 
    0.0005999 
    NA 
    NA 
  
 Genotype 
    categorical 
    level 
    Genotype 
    E2E3 
    30 (12%) 
    7 (7.7%) 
    0.0005999 
    NA 
    Fisher (sim.) 
    NA 
    FALSE 
    0.0005999 
    NA 
    NA 
  
 Genotype 
    categorical 
    level 
    Genotype 
    E2E4 
    7 (2.9%) 
    1 (1.1%) 
    0.0005999 
    NA 
    Fisher (sim.) 
    NA 
    FALSE 
    0.0005999 
    NA 
    NA 
  
 Genotype 
    categorical 
    level 
    Genotype 
    E3E3 
    133 (55%) 
    34 (37%) 
    0.0005999 
    NA 
    Fisher (sim.) 
    NA 
    FALSE 
    0.0005999 
    NA 
    NA 
  
 Genotype 
    categorical 
    level 
    Genotype 
    E3E4 
    65 (27%) 
    41 (45%) 
    0.0005999 
    NA 
    Fisher (sim.) 
    NA 
    FALSE 
    0.0005999 
    NA 
    NA 
  
 Genotype 
    categorical 
    level 
    Genotype 
    E4E4 
    5 (2.1%) 
    8 (8.8%) 
    0.0005999 
    NA 
    Fisher (sim.) 
    NA 
    FALSE 
    0.0005999 
    NA 
    NA 
  
 ACE_CD143_Angiotensin_Converti 
    continuous 
    label 
    Angiotensin-converting enzyme 
    Angiotensin-converting enzyme 
    1.32 (0.56) 
    1.31 (0.53) 
    0.8846265 
    NA 
    Welch t-test 
    NA 
    TRUE 
    0.8846265 
    0.885 
    Welch t-test 
  
 ACTH_Adrenocorticotropic_Hormon 
    continuous 
    label 
    Adrenocorticotropic hormone 
    Adrenocorticotropic hormone 
    -1.55 (0.27) 
    -1.51 (0.29) 
    0.3228133 
    NA 
    Welch t-test 
    NA 
    TRUE 
    0.3228133 
    0.323 
    Welch t-test 
  
 AXL 
    continuous 
    label 
    AXL receptor tyrosine kinase 
    AXL receptor tyrosine kinase 
    0.28 (0.46) 
    0.34 (0.41) 
    0.2384182 
    NA 
    Welch t-test 
    NA 
    TRUE 
    0.2384182 
    0.238 
    Welch t-test 
  
 Adiponectin 
    continuous 
    label 
    Adiponectin 
    Adiponectin 
    -5.26 (0.65) 
    -5.10 (0.69) 
    0.0538971 
    NA 
    Welch t-test 
    NA 
    TRUE 
    0.0538971 
    0.0539 
    Welch t-test 
  
 Alpha_1_Antichymotrypsin 
    continuous 
    label 
    Alpha-1-antichymotrypsin 
    Alpha-1-antichymotrypsin 
    1.32 (0.36) 
    1.44 (0.37) 
    0.0096393 
    NA 
    Welch t-test 
    NA 
    TRUE 
    0.0096393 
    0.00964 
    Welch t-test 
  
 Alpha_1_Antitrypsin 
    continuous 
    label 
    Alpha-1-antitrypsin 
    Alpha-1-antitrypsin 
    -13.33 (1.51) 
    -12.62 (1.52) 
    0.0001841 
    NA 
    Welch t-test 
    NA 
    TRUE 
    0.0001841 
    <0.001 
    Welch t-test 
  
 Alpha_1_Microglobulin 
    continuous 
    label 
    Alpha-1-microglobulin 
    Alpha-1-microglobulin 
    -2.99 (0.48) 
    -2.82 (0.45) 
    0.0030400 
    NA 
    Welch t-test 
    NA 
    TRUE 
    0.0030400 
    0.00304 
    Welch t-test 
  
 Alpha_2_Macroglobulin 
    continuous 
    label 
    Alpha-2-macroglobulin 
    Alpha-2-macroglobulin 
    -162.49 (41.36) 
    -151.41 (38.78) 
    0.0237020 
    NA 
    Welch t-test 
    NA 
    TRUE 
    0.0237020 
    0.0237 
    Welch t-test 
  
 Angiopoietin_2_ANG_2 
    continuous 
    label 
    Angiopoietin-2 
    Angiopoietin-2 
    0.65 (0.33) 
    0.70 (0.34) 
    0.2243927 
    NA 
    Welch t-test 
    NA 
    TRUE 
    0.2243927 
    0.224 
    Welch t-test 
  
 Angiotensinogen 
    continuous 
    label 
    Angiotensinogen 
    Angiotensinogen 
    2.31 (0.25) 
    2.38 (0.25) 
    0.0363220 
    NA 
    Welch t-test 
    NA 
    TRUE 
    0.0363220 
    0.0363 
    Welch t-test 
  
 Apolipoprotein_A_IV 
    continuous 
    label 
    Apolipoprotein A-IV 
    Apolipoprotein A-IV 
    -1.86 (0.39) 
    -1.84 (0.37) 
    0.6196039 
    NA 
    Welch t-test 
    NA 
    TRUE 
    0.6196039 
    0.62 
    Welch t-test 
  
 Apolipoprotein_A1 
    continuous 
    label 
    Apolipoprotein A-1 
    Apolipoprotein A-1 
    -7.48 (0.43) 
    -7.50 (0.44) 
    0.6901145 
    NA 
    Welch t-test 
    NA 
    TRUE 
    0.6901145 
    0.69 
    Welch t-test 
  
 Apolipoprotein_A2 
    continuous 
    label 
    Apolipoprotein A-2 
    Apolipoprotein A-2 
    -0.66 (0.50) 
    -0.61 (0.48) 
    0.3909281 
    NA 
    Welch t-test 
    NA 
    TRUE 
    0.3909281 
    0.391 
    Welch t-test 
  
 Apolipoprotein_B 
    continuous 
    label 
    Apolipoprotein B 
    Apolipoprotein B 
    -5.71 (1.40) 
    -5.27 (1.55) 
    0.0183210 
    NA 
    Welch t-test 
    NA 
    TRUE 
    0.0183210 
    0.0183 
    Welch t-test 
  
 Apolipoprotein_CI 
    continuous 
    label 
    Apolipoprotein C-I 
    Apolipoprotein C-I 
    -1.60 (0.41) 
    -1.58 (0.45) 
    0.8186647 
    NA 
    Welch t-test 
    NA 
    TRUE 
    0.8186647 
    0.819 
    Welch t-test 
  
 Apolipoprotein_CIII 
    continuous 
    label 
    Apolipoprotein C-III 
    Apolipoprotein C-III 
    -2.53 (0.44) 
    -2.42 (0.44) 
    0.0350373 
    NA 
    Welch t-test 
    NA 
    TRUE 
    0.0350373 
    0.035 
    Welch t-test 
  
 Apolipoprotein_D 
    continuous 
    label 
    Apolipoprotein D 
    Apolipoprotein D 
    1.39 (0.33) 
    1.54 (0.38) 
    0.0015555 
    NA 
    Welch t-test 
    NA 
    TRUE 
    0.0015555 
    0.00156 
    Welch t-test 
  
 Apolipoprotein_E 
    continuous 
    label 
    Apolipoprotein E 
    Apolipoprotein E 
    2.79 (0.77) 
    2.78 (0.87) 
    0.8668217 
    NA 
    Welch t-test 
    NA 
    TRUE 
    0.8668217 
    0.867 
    Welch t-test 
  
 Apolipoprotein_H 
    continuous 
    label 
    Apolipoprotein H 
    Apolipoprotein H 
    -0.35 (0.38) 
    -0.23 (0.38) 
    0.0106232 
    NA 
    Welch t-test 
    NA 
    TRUE 
    0.0106232 
    0.0106 
    Welch t-test 
  
 B_Lymphocyte_Chemoattractant_BL 
    continuous 
    label 
    B-lymphocyte chemoattractant 
    B-lymphocyte chemoattractant 
    1.92 (0.57) 
    2.16 (0.56) 
    0.0007177 
    NA 
    Welch t-test 
    NA 
    TRUE 
    0.0007177 
    <0.001 
    Welch t-test 
  
 BMP_6 
    continuous 
    label 
    Bone morphogenetic protein 6 
    Bone morphogenetic protein 6 
    -1.89 (0.29) 
    -1.92 (0.33) 
    0.5218752 
    NA 
    Welch t-test 
    NA 
    TRUE 
    0.5218752 
    0.522 
    Welch t-test 
  
 Beta_2_Microglobulin 
    continuous 
    label 
    Beta-2-microglobulin 
    Beta-2-microglobulin 
    0.16 (0.29) 
    0.19 (0.31) 
    0.4233981 
    NA 
    Welch t-test 
    NA 
    TRUE 
    0.4233981 
    0.423 
    Welch t-test 
  
 Betacellulin 
    continuous 
    label 
    Betacellulin 
    Betacellulin 
    51.63 (10.91) 
    50.62 (10.60) 
    0.4399492 
    NA 
    Welch t-test 
    NA 
    TRUE 
    0.4399492 
    0.44 
    Welch t-test 
  
 C_Reactive_Protein 
    continuous 
    label 
    C-reactive protein 
    C-reactive protein 
    -5.87 (1.22) 
    -5.97 (1.14) 
    0.4843525 
    NA 
    Welch t-test 
    NA 
    TRUE 
    0.4843525 
    0.484 
    Welch t-test 
  
 CD40 
    continuous 
    label 
    CD40 
    CD40 
    -1.26 (0.21) 
    -1.28 (0.24) 
    0.5003297 
    NA 
    Welch t-test 
    NA 
    TRUE 
    0.5003297 
    0.5 
    Welch t-test 
  
 CD5L 
    continuous 
    label 
    CD5L 
    CD5L 
    -0.10 (0.44) 
    0.04 (0.49) 
    0.0247260 
    NA 
    Welch t-test 
    NA 
    TRUE 
    0.0247260 
    0.0247 
    Welch t-test 
  
 Calbindin 
    continuous 
    label 
    Calbindin 
    Calbindin 
    21.99 (3.90) 
    22.93 (4.85) 
    0.1011017 
    NA 
    Welch t-test 
    NA 
    TRUE 
    0.1011017 
    0.101 
    Welch t-test 
  
 Calcitonin 
    continuous 
    label 
    Calcitonin 
    Calcitonin 
    1.68 (0.85) 
    1.71 (0.94) 
    0.7808643 
    NA 
    Welch t-test 
    NA 
    TRUE 
    0.7808643 
    0.781 
    Welch t-test 
  
 CgA 
    continuous 
    label 
    Chromogranin A 
    Chromogranin A 
    329.78 (82.65) 
    333.17 (81.12) 
    0.7351867 
    NA 
    Welch t-test 
    NA 
    TRUE 
    0.7351867 
    0.735 
    Welch t-test 
  
 Clusterin_Apo_J 
    continuous 
    label 
    Clusterin (ApoJ) 
    Clusterin (ApoJ) 
    2.85 (0.29) 
    2.95 (0.33) 
    0.0116372 
    NA 
    Welch t-test 
    NA 
    TRUE 
    0.0116372 
    0.0116 
    Welch t-test 
  
 Complement_3 
    continuous 
    label 
    Complement component 3 
    Complement component 3 
    -15.95 (2.45) 
    -14.92 (2.43) 
    0.0007632 
    NA 
    Welch t-test 
    NA 
    TRUE 
    0.0007632 
    <0.001 
    Welch t-test 
  
 Complement_Factor_H 
    continuous 
    label 
    Complement factor H 
    Complement factor H 
    3.48 (1.26) 
    3.62 (1.22) 
    0.3580892 
    NA 
    Welch t-test 
    NA 
    TRUE 
    0.3580892 
    0.358 
    Welch t-test 
  
 Connective_Tissue_Growth_Factor 
    continuous 
    label 
    Connective tissue growth factor 
    Connective tissue growth factor 
    0.76 (0.21) 
    0.79 (0.20) 
    0.2752610 
    NA 
    Welch t-test 
    NA 
    TRUE 
    0.2752610 
    0.275 
    Welch t-test 
  
 Cortisol 
    continuous 
    label 
    Cortisol 
    Cortisol 
    11.22 (3.73) 
    12.93 (4.34) 
    0.0011179 
    NA 
    Welch t-test 
    NA 
    TRUE 
    0.0011179 
    0.00112 
    Welch t-test 
  
 Creatine_Kinase_MB 
    continuous 
    label 
    Creatine kinase-MB 
    Creatine kinase-MB 
    -1.66 (0.10) 
    -1.70 (0.08) 
    0.0001039 
    NA 
    Welch t-test 
    NA 
    TRUE 
    0.0001039 
    <0.001 
    Welch t-test 
  
 Cystatin_C 
    continuous 
    label 
    Cystatin C 
    Cystatin C 
    8.62 (0.40) 
    8.48 (0.40) 
    0.0055073 
    NA 
    Welch t-test 
    NA 
    TRUE 
    0.0055073 
    0.00551 
    Welch t-test 
  
 EGF_R 
    continuous 
    label 
    Epidermal growth factor receptor 
    Epidermal growth factor receptor 
    -0.71 (0.24) 
    -0.68 (0.22) 
    0.4379144 
    NA 
    Welch t-test 
    NA 
    TRUE 
    0.4379144 
    0.438 
    Welch t-test 
  
 EN_RAGE 
    continuous 
    label 
    EN-RAGE (extracellular newly identified RAGE-binding protein) 
    EN-RAGE (extracellular newly identified RAGE-binding protein) 
    -3.62 (0.90) 
    -3.65 (0.88) 
    0.7659387 
    NA 
    Welch t-test 
    NA 
    TRUE 
    0.7659387 
    0.766 
    Welch t-test 
  
 ENA_78 
    continuous 
    label 
    ENA-78 (epithelial-derived neutrophil-activating protein 78) 
    ENA-78 (epithelial-derived neutrophil-activating protein 78) 
    -1.37 (0.01) 
    -1.37 (0.01) 
    0.9254390 
    NA 
    Welch t-test 
    NA 
    TRUE 
    0.9254390 
    0.925 
    Welch t-test 
  
 Eotaxin_3 
    continuous 
    label 
    Eotaxin-3 
    Eotaxin-3 
    55.36 (15.98) 
    63.75 (15.86) 
    0.0000303 
    NA 
    Welch t-test 
    NA 
    TRUE 
    0.0000303 
    <0.001 
    Welch t-test 
  
 FAS 
    continuous 
    label 
    Fas (tumor necrosis factor receptor superfamily member 6) 
    Fas (tumor necrosis factor receptor superfamily member 6) 
    -0.58 (0.28) 
    -0.40 (0.31) 
    0.0000019 
    NA 
    Welch t-test 
    NA 
    TRUE 
    0.0000019 
    <0.001 
    Welch t-test 
  
 FSH_Follicle_Stimulation_Hormon 
    continuous 
    label 
    Follicle-stimulating hormone 
    Follicle-stimulating hormone 
    -1.12 (0.39) 
    -1.15 (0.43) 
    0.6164374 
    NA 
    Welch t-test 
    NA 
    TRUE 
    0.6164374 
    0.616 
    Welch t-test 
  
 Fas_Ligand 
    continuous 
    label 
    Fas ligand 
    Fas ligand 
    2.79 (1.05) 
    3.22 (1.12) 
    0.0015514 
    NA 
    Welch t-test 
    NA 
    TRUE 
    0.0015514 
    0.00155 
    Welch t-test 
  
 Fatty_Acid_Binding_Protein 
    continuous 
    label 
    Fatty acid-binding protein 
    Fatty acid-binding protein 
    1.24 (0.73) 
    1.59 (0.86) 
    0.0007710 
    NA 
    Welch t-test 
    NA 
    TRUE 
    0.0007710 
    <0.001 
    Welch t-test 
  
 Ferritin 
    continuous 
    label 
    Ferritin 
    Ferritin 
    2.70 (0.76) 
    2.90 (0.83) 
    0.0426440 
    NA 
    Welch t-test 
    NA 
    TRUE 
    0.0426440 
    0.0426 
    Welch t-test 
  
 Fetuin_A 
    continuous 
    label 
    Fetuin-A 
    Fetuin-A 
    1.32 (0.40) 
    1.44 (0.34) 
    0.0314522 
    NA 
    Welch t-test 
    NA 
    TRUE 
    0.0314522 
    0.0315 
    Welch t-test 
  
 Fibrinogen 
    continuous 
    label 
    Fibrinogen 
    Fibrinogen 
    -7.45 (0.56) 
    -7.12 (0.57) 
    0.0000075 
    NA 
    Welch t-test 
    NA 
    TRUE 
    0.0000075 
    <0.001 
    Welch t-test 
  
 GRO_alpha 
    continuous 
    label 
    Growth-regulated alpha protein 
    Growth-regulated alpha protein 
    1.37 (0.04) 
    1.40 (0.04) 
    0.0000000 
    NA 
    Welch t-test 
    NA 
    TRUE 
    0.0000000 
    <0.001 
    Welch t-test 
  
 Gamma_Interferon_induced_Monokin 
    continuous 
    label 
    Gamma interferon-induced monokine 
    Gamma interferon-induced monokine 
    2.77 (0.11) 
    2.83 (0.10) 
    0.0000059 
    NA 
    Welch t-test 
    NA 
    TRUE 
    0.0000059 
    <0.001 
    Welch t-test 
  
 Glutathione_S_Transferase_alpha 
    continuous 
    label 
    Glutathione S-transferase alpha 
    Glutathione S-transferase alpha 
    0.95 (0.17) 
    0.96 (0.12) 
    0.5459600 
    NA 
    Welch t-test 
    NA 
    TRUE 
    0.5459600 
    0.546 
    Welch t-test 
  
 HB_EGF 
    continuous 
    label 
    Heparin-binding epidermal growth factor 
    Heparin-binding epidermal growth factor 
    6.70 (1.47) 
    7.20 (1.49) 
    0.0061319 
    NA 
    Welch t-test 
    NA 
    TRUE 
    0.0061319 
    0.00613 
    Welch t-test 
  
 HCC_4 
    continuous 
    label 
    HCC-4 (hemofiltrate CC chemokine-4) 
    HCC-4 (hemofiltrate CC chemokine-4) 
    -3.55 (0.36) 
    -3.40 (0.34) 
    0.0005695 
    NA 
    Welch t-test 
    NA 
    TRUE 
    0.0005695 
    <0.001 
    Welch t-test 
  
 Hepatocyte_Growth_Factor_HGF 
    continuous 
    label 
    Hepatocyte growth factor 
    Hepatocyte growth factor 
    0.17 (0.29) 
    0.27 (0.29) 
    0.0051215 
    NA 
    Welch t-test 
    NA 
    TRUE 
    0.0051215 
    0.00512 
    Welch t-test 
  
 I_309 
    continuous 
    label 
    I-309 (TCA-3) 
    I-309 (TCA-3) 
    2.92 (0.36) 
    3.02 (0.39) 
    0.0337660 
    NA 
    Welch t-test 
    NA 
    TRUE 
    0.0337660 
    0.0338 
    Welch t-test 
  
 ICAM_1 
    continuous 
    label 
    Intercellular adhesion molecule 1 
    Intercellular adhesion molecule 1 
    -0.60 (0.32) 
    -0.56 (0.36) 
    0.3368872 
    NA 
    Welch t-test 
    NA 
    TRUE 
    0.3368872 
    0.337 
    Welch t-test 
  
 IGF_BP_2 
    continuous 
    label 
    Insulin-like growth factor-binding protein 2 
    Insulin-like growth factor-binding protein 2 
    5.28 (0.20) 
    5.38 (0.22) 
    0.0001243 
    NA 
    Welch t-test 
    NA 
    TRUE 
    0.0001243 
    <0.001 
    Welch t-test 
  
 IL_11 
    continuous 
    label 
    Interleukin 11 
    Interleukin 11 
    4.73 (1.39) 
    4.65 (1.53) 
    0.6424064 
    NA 
    Welch t-test 
    NA 
    TRUE 
    0.6424064 
    0.642 
    Welch t-test 
  
 IL_13 
    continuous 
    label 
    Interleukin 13 
    Interleukin 13 
    1.28 (0.01) 
    1.28 (0.01) 
    0.2577007 
    NA 
    Welch t-test 
    NA 
    TRUE 
    0.2577007 
    0.258 
    Welch t-test 
  
 IL_16 
    continuous 
    label 
    Interleukin 16 
    Interleukin 16 
    2.91 (0.67) 
    2.91 (0.65) 
    0.9601492 
    NA 
    Welch t-test 
    NA 
    TRUE 
    0.9601492 
    0.96 
    Welch t-test 
  
 IL_17E 
    continuous 
    label 
    Interleukin 17E 
    Interleukin 17E 
    4.95 (1.41) 
    4.55 (1.07) 
    0.0057222 
    NA 
    Welch t-test 
    NA 
    TRUE 
    0.0057222 
    0.00572 
    Welch t-test 
  
 IL_1alpha 
    continuous 
    label 
    Interleukin 1 alpha 
    Interleukin 1 alpha 
    -7.54 (0.39) 
    -7.48 (0.43) 
    0.3035679 
    NA 
    Welch t-test 
    NA 
    TRUE 
    0.3035679 
    0.304 
    Welch t-test 
  
 IL_3 
    continuous 
    label 
    Interleukin 3 
    Interleukin 3 
    -3.93 (0.51) 
    -3.99 (0.50) 
    0.4067009 
    NA 
    Welch t-test 
    NA 
    TRUE 
    0.4067009 
    0.407 
    Welch t-test 
  
 IL_4 
    continuous 
    label 
    Interleukin 4 
    Interleukin 4 
    1.78 (0.50) 
    1.72 (0.53) 
    0.3623877 
    NA 
    Welch t-test 
    NA 
    TRUE 
    0.3623877 
    0.362 
    Welch t-test 
  
 IL_5 
    continuous 
    label 
    Interleukin 5 
    Interleukin 5 
    0.21 (0.46) 
    0.17 (0.44) 
    0.4598690 
    NA 
    Welch t-test 
    NA 
    TRUE 
    0.4598690 
    0.46 
    Welch t-test 
  
 IL_6 
    continuous 
    label 
    Interleukin 6 
    Interleukin 6 
    -0.15 (0.51) 
    -0.14 (0.62) 
    0.9841252 
    NA 
    Welch t-test 
    NA 
    TRUE 
    0.9841252 
    0.984 
    Welch t-test 
  
 IL_6_Receptor 
    continuous 
    label 
    Interleukin 6 receptor 
    Interleukin 6 receptor 
    0.09 (0.32) 
    0.08 (0.34) 
    0.8068581 
    NA 
    Welch t-test 
    NA 
    TRUE 
    0.8068581 
    0.807 
    Welch t-test 
  
 IL_7 
    continuous 
    label 
    Interleukin 7 
    Interleukin 7 
    3.01 (0.99) 
    2.61 (1.04) 
    0.0017584 
    NA 
    Welch t-test 
    NA 
    TRUE 
    0.0017584 
    0.00176 
    Welch t-test 
  
 IL_8 
    continuous 
    label 
    Interleukin 8 
    Interleukin 8 
    1.70 (0.03) 
    1.71 (0.04) 
    0.0318468 
    NA 
    Welch t-test 
    NA 
    TRUE 
    0.0318468 
    0.0318 
    Welch t-test 
  
 IP_10_Inducible_Protein_10 
    continuous 
    label 
    Inducible protein 10 
    Inducible protein 10 
    5.69 (0.51) 
    5.85 (0.48) 
    0.0084555 
    NA 
    Welch t-test 
    NA 
    TRUE 
    0.0084555 
    0.00846 
    Welch t-test 
  
 IgA 
    continuous 
    label 
    Immunoglobulin A 
    Immunoglobulin A 
    -6.17 (0.75) 
    -5.94 (0.69) 
    0.0078162 
    NA 
    Welch t-test 
    NA 
    TRUE 
    0.0078162 
    0.00782 
    Welch t-test 
  
 Insulin 
    continuous 
    label 
    Insulin 
    Insulin 
    -1.21 (0.33) 
    -1.26 (0.36) 
    0.2895756 
    NA 
    Welch t-test 
    NA 
    TRUE 
    0.2895756 
    0.29 
    Welch t-test 
  
 Kidney_Injury_Molecule_1_KIM_1 
    continuous 
    label 
    Kidney injury molecule 1 
    Kidney injury molecule 1 
    -1.19 (0.03) 
    -1.18 (0.02) 
    0.0048740 
    NA 
    Welch t-test 
    NA 
    TRUE 
    0.0048740 
    0.00487 
    Welch t-test 
  
 LOX_1 
    continuous 
    label 
    Lectin-like oxidized LDL receptor 1 
    Lectin-like oxidized LDL receptor 1 
    1.27 (0.40) 
    1.27 (0.45) 
    0.9876103 
    NA 
    Welch t-test 
    NA 
    TRUE 
    0.9876103 
    0.988 
    Welch t-test 
  
 Leptin 
    continuous 
    label 
    Leptin 
    Leptin 
    -1.48 (0.27) 
    -1.53 (0.26) 
    0.0940108 
    NA 
    Welch t-test 
    NA 
    TRUE 
    0.0940108 
    0.094 
    Welch t-test 
  
 Lipoprotein_a 
    continuous 
    label 
    Lipoprotein(a) 
    Lipoprotein(a) 
    -4.51 (1.03) 
    -4.25 (1.16) 
    0.0629993 
    NA 
    Welch t-test 
    NA 
    TRUE 
    0.0629993 
    0.063 
    Welch t-test 
  
 MCP_1 
    continuous 
    label 
    Monocyte chemoattractant protein 1 
    Monocyte chemoattractant protein 1 
    6.48 (0.26) 
    6.52 (0.25) 
    0.1775721 
    NA 
    Welch t-test 
    NA 
    TRUE 
    0.1775721 
    0.178 
    Welch t-test 
  
 MCP_2 
    continuous 
    label 
    Monocyte chemoattractant protein 2 
    Monocyte chemoattractant protein 2 
    1.78 (0.62) 
    2.07 (0.64) 
    0.0002487 
    NA 
    Welch t-test 
    NA 
    TRUE 
    0.0002487 
    <0.001 
    Welch t-test 
  
 MIF 
    continuous 
    label 
    Macrophage migration inhibitory factor 
    Macrophage migration inhibitory factor 
    -1.93 (0.33) 
    -1.74 (0.29) 
    0.0000004 
    NA 
    Welch t-test 
    NA 
    TRUE 
    0.0000004 
    <0.001 
    Welch t-test 
  
 MIP_1alpha 
    continuous 
    label 
    Macrophage inflammatory protein 1 alpha 
    Macrophage inflammatory protein 1 alpha 
    3.94 (1.05) 
    4.24 (0.88) 
    0.0083499 
    NA 
    Welch t-test 
    NA 
    TRUE 
    0.0083499 
    0.00835 
    Welch t-test 
  
 MIP_1beta 
    continuous 
    label 
    Macrophage inflammatory protein 1 beta 
    Macrophage inflammatory protein 1 beta 
    2.79 (0.38) 
    2.87 (0.40) 
    0.0869483 
    NA 
    Welch t-test 
    NA 
    TRUE 
    0.0869483 
    0.0869 
    Welch t-test 
  
 MMP_2 
    continuous 
    label 
    Matrix metalloproteinase 2 
    Matrix metalloproteinase 2 
    2.95 (0.95) 
    2.81 (0.89) 
    0.2122963 
    NA 
    Welch t-test 
    NA 
    TRUE 
    0.2122963 
    0.212 
    Welch t-test 
  
 MMP_3 
    continuous 
    label 
    Matrix metalloproteinase 3 
    Matrix metalloproteinase 3 
    -2.49 (0.56) 
    -2.36 (0.60) 
    0.0738423 
    NA 
    Welch t-test 
    NA 
    TRUE 
    0.0738423 
    0.0738 
    Welch t-test 
  
 MMP10 
    continuous 
    label 
    Matrix metalloproteinase 10 
    Matrix metalloproteinase 10 
    -3.73 (0.40) 
    -3.42 (0.44) 
    0.0000000 
    NA 
    Welch t-test 
    NA 
    TRUE 
    0.0000000 
    <0.001 
    Welch t-test 
  
 MMP7 
    continuous 
    label 
    Matrix metalloproteinase 7 
    Matrix metalloproteinase 7 
    -4.07 (1.58) 
    -3.21 (1.28) 
    0.0000009 
    NA 
    Welch t-test 
    NA 
    TRUE 
    0.0000009 
    <0.001 
    Welch t-test 
  
 Myoglobin 
    continuous 
    label 
    Myoglobin 
    Myoglobin 
    -1.43 (0.96) 
    -1.23 (0.87) 
    0.0755465 
    NA 
    Welch t-test 
    NA 
    TRUE 
    0.0755465 
    0.0755 
    Welch t-test 
  
 NT_proBNP 
    continuous 
    label 
    N-terminal pro b-type natriuretic peptide 
    N-terminal pro b-type natriuretic peptide 
    4.46 (0.36) 
    4.71 (0.36) 
    0.0000038 
    NA 
    Welch t-test 
    NA 
    TRUE 
    0.0000038 
    <0.001 
    Welch t-test 
  
 NrCAM 
    continuous 
    label 
    Neuron-glia cell adhesion molecule 
    Neuron-glia cell adhesion molecule 
    4.38 (0.56) 
    4.33 (0.54) 
    0.5219452 
    NA 
    Welch t-test 
    NA 
    TRUE 
    0.5219452 
    0.522 
    Welch t-test 
  
 Osteopontin 
    continuous 
    label 
    Osteopontin 
    Osteopontin 
    5.16 (0.38) 
    5.31 (0.41) 
    0.0022081 
    NA 
    Welch t-test 
    NA 
    TRUE 
    0.0022081 
    0.00221 
    Welch t-test 
  
 PAI_1 
    continuous 
    label 
    Plasminogen activator inhibitor 1 
    Plasminogen activator inhibitor 1 
    -0.01 (0.38) 
    0.26 (0.44) 
    0.0000007 
    NA 
    Welch t-test 
    NA 
    TRUE 
    0.0000007 
    <0.001 
    Welch t-test 
  
 PAPP_A 
    continuous 
    label 
    Pregnancy-associated plasma protein A 
    Pregnancy-associated plasma protein A 
    -2.85 (0.14) 
    -2.85 (0.14) 
    0.9612735 
    NA 
    Welch t-test 
    NA 
    TRUE 
    0.9612735 
    0.961 
    Welch t-test 
  
 PLGF 
    continuous 
    label 
    Placental growth factor 
    Placental growth factor 
    3.87 (0.39) 
    4.01 (0.42) 
    0.0045508 
    NA 
    Welch t-test 
    NA 
    TRUE 
    0.0045508 
    0.00455 
    Welch t-test 
  
 PYY 
    continuous 
    label 
    Peptide YY 
    Peptide YY 
    3.01 (0.29) 
    3.01 (0.28) 
    0.8747602 
    NA 
    Welch t-test 
    NA 
    TRUE 
    0.8747602 
    0.875 
    Welch t-test 
  
 Pancreatic_polypeptide 
    continuous 
    label 
    Pancreatic polypeptide 
    Pancreatic polypeptide 
    -0.14 (0.67) 
    0.32 (0.74) 
    0.0000008 
    NA 
    Welch t-test 
    NA 
    TRUE 
    0.0000008 
    <0.001 
    Welch t-test 
  
 Prolactin 
    continuous 
    label 
    Prolactin 
    Prolactin 
    0.03 (0.30) 
    0.09 (0.27) 
    0.1059084 
    NA 
    Welch t-test 
    NA 
    TRUE 
    0.1059084 
    0.106 
    Welch t-test 
  
 Prostatic_Acid_Phosphatase 
    continuous 
    label 
    Prostatic acid phosphatase 
    Prostatic acid phosphatase 
    -1.69 (0.06) 
    -1.68 (0.06) 
    0.0631539 
    NA 
    Welch t-test 
    NA 
    TRUE 
    0.0631539 
    0.0632 
    Welch t-test 
  
 Protein_S 
    continuous 
    label 
    Protein S 
    Protein S 
    -2.27 (0.36) 
    -2.17 (0.37) 
    0.0181327 
    NA 
    Welch t-test 
    NA 
    TRUE 
    0.0181327 
    0.0181 
    Welch t-test 
  
 Pulmonary_and_Activation_Regulat 
    continuous 
    label 
    Pulmonary and activation-regulated chemokine 
    Pulmonary and activation-regulated chemokine 
    -1.56 (0.47) 
    -1.47 (0.35) 
    0.1259992 
    NA 
    Welch t-test 
    NA 
    TRUE 
    0.1259992 
    0.126 
    Welch t-test 
  
 RANTES 
    continuous 
    label 
    Regulated on activation, normal T cell expressed and secreted 
    Regulated on activation, normal T cell expressed and secreted 
    -6.55 (0.31) 
    -6.44 (0.31) 
    0.0044494 
    NA 
    Welch t-test 
    NA 
    TRUE 
    0.0044494 
    0.00445 
    Welch t-test 
  
 Resistin 
    continuous 
    label 
    Resistin 
    Resistin 
    -18.52 (5.42) 
    -15.74 (5.93) 
    0.0001487 
    NA 
    Welch t-test 
    NA 
    TRUE 
    0.0001487 
    <0.001 
    Welch t-test 
  
 S100b 
    continuous 
    label 
    S100 calcium-binding protein B 
    S100 calcium-binding protein B 
    1.21 (0.35) 
    1.32 (0.34) 
    0.0078991 
    NA 
    Welch t-test 
    NA 
    TRUE 
    0.0078991 
    0.0079 
    Welch t-test 
  
 SGOT 
    continuous 
    label 
    Serum glutamic-oxaloacetic transaminase 
    Serum glutamic-oxaloacetic transaminase 
    -0.44 (0.37) 
    -0.37 (0.29) 
    0.0469909 
    NA 
    Welch t-test 
    NA 
    TRUE 
    0.0469909 
    0.047 
    Welch t-test 
  
 SHBG 
    continuous 
    label 
    Sex hormone-binding globulin 
    Sex hormone-binding globulin 
    -2.54 (0.57) 
    -2.45 (0.56) 
    0.1686214 
    NA 
    Welch t-test 
    NA 
    TRUE 
    0.1686214 
    0.169 
    Welch t-test 
  
 SOD 
    continuous 
    label 
    Superoxide dismutase 
    Superoxide dismutase 
    5.31 (0.38) 
    5.39 (0.38) 
    0.0833871 
    NA 
    Welch t-test 
    NA 
    TRUE 
    0.0833871 
    0.0834 
    Welch t-test 
  
 Serum_Amyloid_P 
    continuous 
    label 
    Serum amyloid P component 
    Serum amyloid P component 
    -6.05 (0.55) 
    -5.98 (0.57) 
    0.3236618 
    NA 
    Welch t-test 
    NA 
    TRUE 
    0.3236618 
    0.324 
    Welch t-test 
  
 Sortilin 
    continuous 
    label 
    Sortilin 
    Sortilin 
    3.74 (0.86) 
    4.10 (0.83) 
    0.0005339 
    NA 
    Welch t-test 
    NA 
    TRUE 
    0.0005339 
    <0.001 
    Welch t-test 
  
 Stem_Cell_Factor 
    continuous 
    label 
    Stem cell factor 
    Stem cell factor 
    3.30 (0.36) 
    3.28 (0.34) 
    0.6843984 
    NA 
    Welch t-test 
    NA 
    TRUE 
    0.6843984 
    0.684 
    Welch t-test 
  
 TGF_alpha 
    continuous 
    label 
    Transforming growth factor alpha 
    Transforming growth factor alpha 
    9.73 (1.31) 
    9.96 (1.18) 
    0.1283139 
    NA 
    Welch t-test 
    NA 
    TRUE 
    0.1283139 
    0.128 
    Welch t-test 
  
 TIMP_1 
    continuous 
    label 
    Tissue inhibitor of metalloproteinases 1 
    Tissue inhibitor of metalloproteinases 1 
    11.55 (1.78) 
    12.11 (1.97) 
    0.0209928 
    NA 
    Welch t-test 
    NA 
    TRUE 
    0.0209928 
    0.021 
    Welch t-test 
  
 TNF_RII 
    continuous 
    label 
    Tumor necrosis factor receptor II 
    Tumor necrosis factor receptor II 
    -0.64 (0.32) 
    -0.48 (0.35) 
    0.0002205 
    NA 
    Welch t-test 
    NA 
    TRUE 
    0.0002205 
    <0.001 
    Welch t-test 
  
 TRAIL_R3 
    continuous 
    label 
    TNF-related apoptosis-inducing ligand receptor 3 
    TNF-related apoptosis-inducing ligand receptor 3 
    -0.59 (0.23) 
    -0.43 (0.23) 
    0.0000001 
    NA 
    Welch t-test 
    NA 
    TRUE 
    0.0000001 
    <0.001 
    Welch t-test 
  
 TTR_prealbumin 
    continuous 
    label 
    Transthyretin (prealbumin) 
    Transthyretin (prealbumin) 
    2.86 (0.14) 
    2.84 (0.14) 
    0.4396330 
    NA 
    Welch t-test 
    NA 
    TRUE 
    0.4396330 
    0.44 
    Welch t-test 
  
 Tamm_Horsfall_Protein_THP 
    continuous 
    label 
    Tamm-Horsfall protein 
    Tamm-Horsfall protein 
    -3.12 (0.03) 
    -3.11 (0.03) 
    0.3283328 
    NA 
    Welch t-test 
    NA 
    TRUE 
    0.3283328 
    0.328 
    Welch t-test 
  
 Thrombomodulin 
    continuous 
    label 
    Thrombomodulin 
    Thrombomodulin 
    -1.53 (0.23) 
    -1.45 (0.22) 
    0.0028089 
    NA 
    Welch t-test 
    NA 
    TRUE 
    0.0028089 
    0.00281 
    Welch t-test 
  
 Thrombopoietin 
    continuous 
    label 
    Thrombopoietin 
    Thrombopoietin 
    -0.74 (0.24) 
    -0.81 (0.25) 
    0.0630863 
    NA 
    Welch t-test 
    NA 
    TRUE 
    0.0630863 
    0.0631 
    Welch t-test 
  
 Thymus_Expressed_Chemokine_TECK 
    continuous 
    label 
    Thymus-expressed chemokine (TECK) 
    Thymus-expressed chemokine (TECK) 
    3.73 (0.77) 
    4.11 (0.76) 
    0.0000606 
    NA 
    Welch t-test 
    NA 
    TRUE 
    0.0000606 
    <0.001 
    Welch t-test 
  
 Thyroid_Stimulating_Hormone 
    continuous 
    label 
    Thyroid-stimulating hormone 
    Thyroid-stimulating hormone 
    -4.45 (0.75) 
    -4.43 (0.82) 
    0.8817515 
    NA 
    Welch t-test 
    NA 
    TRUE 
    0.8817515 
    0.882 
    Welch t-test 
  
 Thyroxine_Binding_Globulin 
    continuous 
    label 
    Thyroxine-binding globulin 
    Thyroxine-binding globulin 
    -1.51 (0.40) 
    -1.42 (0.39) 
    0.0668355 
    NA 
    Welch t-test 
    NA 
    TRUE 
    0.0668355 
    0.0668 
    Welch t-test 
  
 Tissue_Factor 
    continuous 
    label 
    Tissue factor 
    Tissue factor 
    1.16 (0.51) 
    1.18 (0.51) 
    0.7382965 
    NA 
    Welch t-test 
    NA 
    TRUE 
    0.7382965 
    0.738 
    Welch t-test 
  
 Transferrin 
    continuous 
    label 
    Transferrin 
    Transferrin 
    2.90 (0.28) 
    2.92 (0.27) 
    0.5677089 
    NA 
    Welch t-test 
    NA 
    TRUE 
    0.5677089 
    0.568 
    Welch t-test 
  
 Trefoil_Factor_3_TFF3 
    continuous 
    label 
    Trefoil factor 3 (TFF3) 
    Trefoil factor 3 (TFF3) 
    -3.90 (0.33) 
    -3.85 (0.36) 
    0.2500022 
    NA 
    Welch t-test 
    NA 
    TRUE 
    0.2500022 
    0.25 
    Welch t-test 
  
 VCAM_1 
    continuous 
    label 
    Vascular cell adhesion molecule 1 
    Vascular cell adhesion molecule 1 
    2.66 (0.30) 
    2.73 (0.37) 
    0.0887835 
    NA 
    Welch t-test 
    NA 
    TRUE 
    0.0887835 
    0.0888 
    Welch t-test 
  
 VEGF 
    continuous 
    label 
    Vascular endothelial growth factor 
    Vascular endothelial growth factor 
    17.14 (1.85) 
    16.37 (1.83) 
    0.0008075 
    NA 
    Welch t-test 
    NA 
    TRUE 
    0.0008075 
    <0.001 
    Welch t-test 
  
 Vitronectin 
    continuous 
    label 
    Vitronectin 
    Vitronectin 
    -0.28 (0.33) 
    -0.28 (0.32) 
    0.9569334 
    NA 
    Welch t-test 
    NA 
    TRUE 
    0.9569334 
    0.957 
    Welch t-test 
  
 von_Willebrand_Factor 
    continuous 
    label 
    von Willebrand factor 
    von Willebrand factor 
    -3.95 (0.37) 
    -3.86 (0.39) 
    0.0473700 
    NA 
    Welch t-test 
    NA 
    TRUE 
    0.0473700 
    0.0474 
    Welch t-test 
  
 tau 
    continuous 
    label 
    Tau protein 
    Tau protein 
    5.61 (0.49) 
    6.14 (0.55) 
    0.0000000 
    NA 
    Welch t-test 
    NA 
    TRUE 
    0.0000000 
    <0.001 
    Welch t-test 
  
 p_tau 
    continuous 
    label 
    Phosphorylated tau protein 
    Phosphorylated tau protein 
    3.94 (0.42) 
    4.30 (0.48) 
    0.0000000 
    NA 
    Welch t-test 
    NA 
    TRUE 
    0.0000000 
    <0.001 
    Welch t-test 
  
 Ab_42 
    continuous 
    label 
    Amyloid beta 42 
    Amyloid beta 42 
    12.80 (1.41) 
    11.27 (1.34) 
    0.0000000 
    NA 
    Welch t-test 
    NA 
    TRUE 
    0.0000000 
    <0.001 
    Welch t-test 
  
 age 
    continuous 
    label 
    Age 
    Age 
    72.75 (13.26) 
    71.78 (13.12) 
    0.5526369 
    NA 
    Welch t-test 
    NA 
    TRUE 
    0.5526369 
    0.553 
    Welch t-test 
  
 sex 
    categorical 
    label 
    Sex 
    Sex 
    NA 
    NA 
    0.0272353 
    NA 
    Pearson chi-squared 
    NA 
    TRUE 
    0.0272353 
    0.0272 
    Pearson chi-squared 
  
 sex 
    categorical 
    level 
    Sex 
    Female 
    157 (65%) 
    47 (52%) 
    0.0272353 
    NA 
    Pearson chi-squared 
    NA 
    FALSE 
    0.0272353 
    NA 
    NA 
  
 sex 
    categorical 
    level 
    Sex 
    Male 
    85 (35%) 
    44 (48%) 
    0.0272353 
    NA 
    Pearson chi-squared 
    NA 
    FALSE 
    0.0272353 
    NA 
    NA 
  
 Genotype 
    categorical 
    label 
    Genotype 
    Genotype 
    NA 
    NA 
    0.0005999 
    NA 
    Fisher (sim.) 
    NA 
    TRUE 
    0.0005999 
    <0.001 
    Fisher (sim.) 
  
 Genotype 
    categorical 
    level 
    Genotype 
    E2E2 
    2 (0.8%) 
    0 (0%) 
    0.0005999 
    NA 
    Fisher (sim.) 
    NA 
    FALSE 
    0.0005999 
    NA 
    NA 
  
 Genotype 
    categorical 
    level 
    Genotype 
    E2E3 
    30 (12%) 
    7 (7.7%) 
    0.0005999 
    NA 
    Fisher (sim.) 
    NA 
    FALSE 
    0.0005999 
    NA 
    NA 
  
 Genotype 
    categorical 
    level 
    Genotype 
    E2E4 
    7 (2.9%) 
    1 (1.1%) 
    0.0005999 
    NA 
    Fisher (sim.) 
    NA 
    FALSE 
    0.0005999 
    NA 
    NA 
  
 Genotype 
    categorical 
    level 
    Genotype 
    E3E3 
    133 (55%) 
    34 (37%) 
    0.0005999 
    NA 
    Fisher (sim.) 
    NA 
    FALSE 
    0.0005999 
    NA 
    NA 
  
 Genotype 
    categorical 
    level 
    Genotype 
    E3E4 
    65 (27%) 
    41 (45%) 
    0.0005999 
    NA 
    Fisher (sim.) 
    NA 
    FALSE 
    0.0005999 
    NA 
    NA 
  
 Genotype 
    categorical 
    level 
    Genotype 
    E4E4 
    5 (2.1%) 
    8 (8.8%) 
    0.0005999 
    NA 
    Fisher (sim.) 
    NA 
    FALSE 
    0.0005999 
    NA 
    NA 
  
 ACE_CD143_Angiotensin_Converti 
    continuous 
    label 
    Angiotensin-converting enzyme 
    Angiotensin-converting enzyme 
    1.32 (0.56) 
    1.31 (0.53) 
    0.8846265 
    NA 
    Welch t-test 
    NA 
    TRUE 
    0.8846265 
    0.885 
    Welch t-test 
  
 ACTH_Adrenocorticotropic_Hormon 
    continuous 
    label 
    Adrenocorticotropic hormone 
    Adrenocorticotropic hormone 
    -1.55 (0.27) 
    -1.51 (0.29) 
    0.3228133 
    NA 
    Welch t-test 
    NA 
    TRUE 
    0.3228133 
    0.323 
    Welch t-test 
  
 AXL 
    continuous 
    label 
    AXL receptor tyrosine kinase 
    AXL receptor tyrosine kinase 
    0.28 (0.46) 
    0.34 (0.41) 
    0.2384182 
    NA 
    Welch t-test 
    NA 
    TRUE 
    0.2384182 
    0.238 
    Welch t-test 
  
 Adiponectin 
    continuous 
    label 
    Adiponectin 
    Adiponectin 
    -5.26 (0.65) 
    -5.10 (0.69) 
    0.0538971 
    NA 
    Welch t-test 
    NA 
    TRUE 
    0.0538971 
    0.0539 
    Welch t-test 
  
 Alpha_1_Antichymotrypsin 
    continuous 
    label 
    Alpha-1-antichymotrypsin 
    Alpha-1-antichymotrypsin 
    1.32 (0.36) 
    1.44 (0.37) 
    0.0096393 
    NA 
    Welch t-test 
    NA 
    TRUE 
    0.0096393 
    0.00964 
    Welch t-test 
  
 Alpha_1_Antitrypsin 
    continuous 
    label 
    Alpha-1-antitrypsin 
    Alpha-1-antitrypsin 
    -13.33 (1.51) 
    -12.62 (1.52) 
    0.0001841 
    NA 
    Welch t-test 
    NA 
    TRUE 
    0.0001841 
    <0.001 
    Welch t-test 
  
 Alpha_1_Microglobulin 
    continuous 
    label 
    Alpha-1-microglobulin 
    Alpha-1-microglobulin 
    -2.99 (0.48) 
    -2.82 (0.45) 
    0.0030400 
    NA 
    Welch t-test 
    NA 
    TRUE 
    0.0030400 
    0.00304 
    Welch t-test 
  
 Alpha_2_Macroglobulin 
    continuous 
    label 
    Alpha-2-macroglobulin 
    Alpha-2-macroglobulin 
    -162.49 (41.36) 
    -151.41 (38.78) 
    0.0237020 
    NA 
    Welch t-test 
    NA 
    TRUE 
    0.0237020 
    0.0237 
    Welch t-test 
  
 Angiopoietin_2_ANG_2 
    continuous 
    label 
    Angiopoietin-2 
    Angiopoietin-2 
    0.65 (0.33) 
    0.70 (0.34) 
    0.2243927 
    NA 
    Welch t-test 
    NA 
    TRUE 
    0.2243927 
    0.224 
    Welch t-test 
  
 Angiotensinogen 
    continuous 
    label 
    Angiotensinogen 
    Angiotensinogen 
    2.31 (0.25) 
    2.38 (0.25) 
    0.0363220 
    NA 
    Welch t-test 
    NA 
    TRUE 
    0.0363220 
    0.0363 
    Welch t-test 
  
 Apolipoprotein_A_IV 
    continuous 
    label 
    Apolipoprotein A-IV 
    Apolipoprotein A-IV 
    -1.86 (0.39) 
    -1.84 (0.37) 
    0.6196039 
    NA 
    Welch t-test 
    NA 
    TRUE 
    0.6196039 
    0.62 
    Welch t-test 
  
 Apolipoprotein_A1 
    continuous 
    label 
    Apolipoprotein A-1 
    Apolipoprotein A-1 
    -7.48 (0.43) 
    -7.50 (0.44) 
    0.6901145 
    NA 
    Welch t-test 
    NA 
    TRUE 
    0.6901145 
    0.69 
    Welch t-test 
  
 Apolipoprotein_A2 
    continuous 
    label 
    Apolipoprotein A-2 
    Apolipoprotein A-2 
    -0.66 (0.50) 
    -0.61 (0.48) 
    0.3909281 
    NA 
    Welch t-test 
    NA 
    TRUE 
    0.3909281 
    0.391 
    Welch t-test 
  
 Apolipoprotein_B 
    continuous 
    label 
    Apolipoprotein B 
    Apolipoprotein B 
    -5.71 (1.40) 
    -5.27 (1.55) 
    0.0183210 
    NA 
    Welch t-test 
    NA 
    TRUE 
    0.0183210 
    0.0183 
    Welch t-test 
  
 Apolipoprotein_CI 
    continuous 
    label 
    Apolipoprotein C-I 
    Apolipoprotein C-I 
    -1.60 (0.41) 
    -1.58 (0.45) 
    0.8186647 
    NA 
    Welch t-test 
    NA 
    TRUE 
    0.8186647 
    0.819 
    Welch t-test 
  
 Apolipoprotein_CIII 
    continuous 
    label 
    Apolipoprotein C-III 
    Apolipoprotein C-III 
    -2.53 (0.44) 
    -2.42 (0.44) 
    0.0350373 
    NA 
    Welch t-test 
    NA 
    TRUE 
    0.0350373 
    0.035 
    Welch t-test 
  
 Apolipoprotein_D 
    continuous 
    label 
    Apolipoprotein D 
    Apolipoprotein D 
    1.39 (0.33) 
    1.54 (0.38) 
    0.0015555 
    NA 
    Welch t-test 
    NA 
    TRUE 
    0.0015555 
    0.00156 
    Welch t-test 
  
 Apolipoprotein_E 
    continuous 
    label 
    Apolipoprotein E 
    Apolipoprotein E 
    2.79 (0.77) 
    2.78 (0.87) 
    0.8668217 
    NA 
    Welch t-test 
    NA 
    TRUE 
    0.8668217 
    0.867 
    Welch t-test 
  
 Apolipoprotein_H 
    continuous 
    label 
    Apolipoprotein H 
    Apolipoprotein H 
    -0.35 (0.38) 
    -0.23 (0.38) 
    0.0106232 
    NA 
    Welch t-test 
    NA 
    TRUE 
    0.0106232 
    0.0106 
    Welch t-test 
  
 B_Lymphocyte_Chemoattractant_BL 
    continuous 
    label 
    B-lymphocyte chemoattractant 
    B-lymphocyte chemoattractant 
    1.92 (0.57) 
    2.16 (0.56) 
    0.0007177 
    NA 
    Welch t-test 
    NA 
    TRUE 
    0.0007177 
    <0.001 
    Welch t-test 
  
 BMP_6 
    continuous 
    label 
    Bone morphogenetic protein 6 
    Bone morphogenetic protein 6 
    -1.89 (0.29) 
    -1.92 (0.33) 
    0.5218752 
    NA 
    Welch t-test 
    NA 
    TRUE 
    0.5218752 
    0.522 
    Welch t-test 
  
 Beta_2_Microglobulin 
    continuous 
    label 
    Beta-2-microglobulin 
    Beta-2-microglobulin 
    0.16 (0.29) 
    0.19 (0.31) 
    0.4233981 
    NA 
    Welch t-test 
    NA 
    TRUE 
    0.4233981 
    0.423 
    Welch t-test 
  
 Betacellulin 
    continuous 
    label 
    Betacellulin 
    Betacellulin 
    51.63 (10.91) 
    50.62 (10.60) 
    0.4399492 
    NA 
    Welch t-test 
    NA 
    TRUE 
    0.4399492 
    0.44 
    Welch t-test 
  
 C_Reactive_Protein 
    continuous 
    label 
    C-reactive protein 
    C-reactive protein 
    -5.87 (1.22) 
    -5.97 (1.14) 
    0.4843525 
    NA 
    Welch t-test 
    NA 
    TRUE 
    0.4843525 
    0.484 
    Welch t-test 
  
 CD40 
    continuous 
    label 
    CD40 
    CD40 
    -1.26 (0.21) 
    -1.28 (0.24) 
    0.5003297 
    NA 
    Welch t-test 
    NA 
    TRUE 
    0.5003297 
    0.5 
    Welch t-test 
  
 CD5L 
    continuous 
    label 
    CD5L 
    CD5L 
    -0.10 (0.44) 
    0.04 (0.49) 
    0.0247260 
    NA 
    Welch t-test 
    NA 
    TRUE 
    0.0247260 
    0.0247 
    Welch t-test 
  
 Calbindin 
    continuous 
    label 
    Calbindin 
    Calbindin 
    21.99 (3.90) 
    22.93 (4.85) 
    0.1011017 
    NA 
    Welch t-test 
    NA 
    TRUE 
    0.1011017 
    0.101 
    Welch t-test 
  
 Calcitonin 
    continuous 
    label 
    Calcitonin 
    Calcitonin 
    1.68 (0.85) 
    1.71 (0.94) 
    0.7808643 
    NA 
    Welch t-test 
    NA 
    TRUE 
    0.7808643 
    0.781 
    Welch t-test 
  
 CgA 
    continuous 
    label 
    Chromogranin A 
    Chromogranin A 
    329.78 (82.65) 
    333.17 (81.12) 
    0.7351867 
    NA 
    Welch t-test 
    NA 
    TRUE 
    0.7351867 
    0.735 
    Welch t-test 
  
 Clusterin_Apo_J 
    continuous 
    label 
    Clusterin (ApoJ) 
    Clusterin (ApoJ) 
    2.85 (0.29) 
    2.95 (0.33) 
    0.0116372 
    NA 
    Welch t-test 
    NA 
    TRUE 
    0.0116372 
    0.0116 
    Welch t-test 
  
 Complement_3 
    continuous 
    label 
    Complement component 3 
    Complement component 3 
    -15.95 (2.45) 
    -14.92 (2.43) 
    0.0007632 
    NA 
    Welch t-test 
    NA 
    TRUE 
    0.0007632 
    <0.001 
    Welch t-test 
  
 Complement_Factor_H 
    continuous 
    label 
    Complement factor H 
    Complement factor H 
    3.48 (1.26) 
    3.62 (1.22) 
    0.3580892 
    NA 
    Welch t-test 
    NA 
    TRUE 
    0.3580892 
    0.358 
    Welch t-test 
  
 Connective_Tissue_Growth_Factor 
    continuous 
    label 
    Connective tissue growth factor 
    Connective tissue growth factor 
    0.76 (0.21) 
    0.79 (0.20) 
    0.2752610 
    NA 
    Welch t-test 
    NA 
    TRUE 
    0.2752610 
    0.275 
    Welch t-test 
  
 Cortisol 
    continuous 
    label 
    Cortisol 
    Cortisol 
    11.22 (3.73) 
    12.93 (4.34) 
    0.0011179 
    NA 
    Welch t-test 
    NA 
    TRUE 
    0.0011179 
    0.00112 
    Welch t-test 
  
 Creatine_Kinase_MB 
    continuous 
    label 
    Creatine kinase-MB 
    Creatine kinase-MB 
    -1.66 (0.10) 
    -1.70 (0.08) 
    0.0001039 
    NA 
    Welch t-test 
    NA 
    TRUE 
    0.0001039 
    <0.001 
    Welch t-test 
  
 Cystatin_C 
    continuous 
    label 
    Cystatin C 
    Cystatin C 
    8.62 (0.40) 
    8.48 (0.40) 
    0.0055073 
    NA 
    Welch t-test 
    NA 
    TRUE 
    0.0055073 
    0.00551 
    Welch t-test 
  
 EGF_R 
    continuous 
    label 
    Epidermal growth factor receptor 
    Epidermal growth factor receptor 
    -0.71 (0.24) 
    -0.68 (0.22) 
    0.4379144 
    NA 
    Welch t-test 
    NA 
    TRUE 
    0.4379144 
    0.438 
    Welch t-test 
  
 EN_RAGE 
    continuous 
    label 
    EN-RAGE (extracellular newly identified RAGE-binding protein) 
    EN-RAGE (extracellular newly identified RAGE-binding protein) 
    -3.62 (0.90) 
    -3.65 (0.88) 
    0.7659387 
    NA 
    Welch t-test 
    NA 
    TRUE 
    0.7659387 
    0.766 
    Welch t-test 
  
 ENA_78 
    continuous 
    label 
    ENA-78 (epithelial-derived neutrophil-activating protein 78) 
    ENA-78 (epithelial-derived neutrophil-activating protein 78) 
    -1.37 (0.01) 
    -1.37 (0.01) 
    0.9254390 
    NA 
    Welch t-test 
    NA 
    TRUE 
    0.9254390 
    0.925 
    Welch t-test 
  
 Eotaxin_3 
    continuous 
    label 
    Eotaxin-3 
    Eotaxin-3 
    55.36 (15.98) 
    63.75 (15.86) 
    0.0000303 
    NA 
    Welch t-test 
    NA 
    TRUE 
    0.0000303 
    <0.001 
    Welch t-test 
  
 FAS 
    continuous 
    label 
    Fas (tumor necrosis factor receptor superfamily member 6) 
    Fas (tumor necrosis factor receptor superfamily member 6) 
    -0.58 (0.28) 
    -0.40 (0.31) 
    0.0000019 
    NA 
    Welch t-test 
    NA 
    TRUE 
    0.0000019 
    <0.001 
    Welch t-test 
  
 FSH_Follicle_Stimulation_Hormon 
    continuous 
    label 
    Follicle-stimulating hormone 
    Follicle-stimulating hormone 
    -1.12 (0.39) 
    -1.15 (0.43) 
    0.6164374 
    NA 
    Welch t-test 
    NA 
    TRUE 
    0.6164374 
    0.616 
    Welch t-test 
  
 Fas_Ligand 
    continuous 
    label 
    Fas ligand 
    Fas ligand 
    2.79 (1.05) 
    3.22 (1.12) 
    0.0015514 
    NA 
    Welch t-test 
    NA 
    TRUE 
    0.0015514 
    0.00155 
    Welch t-test 
  
 Fatty_Acid_Binding_Protein 
    continuous 
    label 
    Fatty acid-binding protein 
    Fatty acid-binding protein 
    1.24 (0.73) 
    1.59 (0.86) 
    0.0007710 
    NA 
    Welch t-test 
    NA 
    TRUE 
    0.0007710 
    <0.001 
    Welch t-test 
  
 Ferritin 
    continuous 
    label 
    Ferritin 
    Ferritin 
    2.70 (0.76) 
    2.90 (0.83) 
    0.0426440 
    NA 
    Welch t-test 
    NA 
    TRUE 
    0.0426440 
    0.0426 
    Welch t-test 
  
 Fetuin_A 
    continuous 
    label 
    Fetuin-A 
    Fetuin-A 
    1.32 (0.40) 
    1.44 (0.34) 
    0.0314522 
    NA 
    Welch t-test 
    NA 
    TRUE 
    0.0314522 
    0.0315 
    Welch t-test 
  
 Fibrinogen 
    continuous 
    label 
    Fibrinogen 
    Fibrinogen 
    -7.45 (0.56) 
    -7.12 (0.57) 
    0.0000075 
    NA 
    Welch t-test 
    NA 
    TRUE 
    0.0000075 
    <0.001 
    Welch t-test 
  
 GRO_alpha 
    continuous 
    label 
    Growth-regulated alpha protein 
    Growth-regulated alpha protein 
    1.37 (0.04) 
    1.40 (0.04) 
    0.0000000 
    NA 
    Welch t-test 
    NA 
    TRUE 
    0.0000000 
    <0.001 
    Welch t-test 
  
 Gamma_Interferon_induced_Monokin 
    continuous 
    label 
    Gamma interferon-induced monokine 
    Gamma interferon-induced monokine 
    2.77 (0.11) 
    2.83 (0.10) 
    0.0000059 
    NA 
    Welch t-test 
    NA 
    TRUE 
    0.0000059 
    <0.001 
    Welch t-test 
  
 Glutathione_S_Transferase_alpha 
    continuous 
    label 
    Glutathione S-transferase alpha 
    Glutathione S-transferase alpha 
    0.95 (0.17) 
    0.96 (0.12) 
    0.5459600 
    NA 
    Welch t-test 
    NA 
    TRUE 
    0.5459600 
    0.546 
    Welch t-test 
  
 HB_EGF 
    continuous 
    label 
    Heparin-binding epidermal growth factor 
    Heparin-binding epidermal growth factor 
    6.70 (1.47) 
    7.20 (1.49) 
    0.0061319 
    NA 
    Welch t-test 
    NA 
    TRUE 
    0.0061319 
    0.00613 
    Welch t-test 
  
 HCC_4 
    continuous 
    label 
    HCC-4 (hemofiltrate CC chemokine-4) 
    HCC-4 (hemofiltrate CC chemokine-4) 
    -3.55 (0.36) 
    -3.40 (0.34) 
    0.0005695 
    NA 
    Welch t-test 
    NA 
    TRUE 
    0.0005695 
    <0.001 
    Welch t-test 
  
 Hepatocyte_Growth_Factor_HGF 
    continuous 
    label 
    Hepatocyte growth factor 
    Hepatocyte growth factor 
    0.17 (0.29) 
    0.27 (0.29) 
    0.0051215 
    NA 
    Welch t-test 
    NA 
    TRUE 
    0.0051215 
    0.00512 
    Welch t-test 
  
 I_309 
    continuous 
    label 
    I-309 (TCA-3) 
    I-309 (TCA-3) 
    2.92 (0.36) 
    3.02 (0.39) 
    0.0337660 
    NA 
    Welch t-test 
    NA 
    TRUE 
    0.0337660 
    0.0338 
    Welch t-test 
  
 ICAM_1 
    continuous 
    label 
    Intercellular adhesion molecule 1 
    Intercellular adhesion molecule 1 
    -0.60 (0.32) 
    -0.56 (0.36) 
    0.3368872 
    NA 
    Welch t-test 
    NA 
    TRUE 
    0.3368872 
    0.337 
    Welch t-test 
  
 IGF_BP_2 
    continuous 
    label 
    Insulin-like growth factor-binding protein 2 
    Insulin-like growth factor-binding protein 2 
    5.28 (0.20) 
    5.38 (0.22) 
    0.0001243 
    NA 
    Welch t-test 
    NA 
    TRUE 
    0.0001243 
    <0.001 
    Welch t-test 
  
 IL_11 
    continuous 
    label 
    Interleukin 11 
    Interleukin 11 
    4.73 (1.39) 
    4.65 (1.53) 
    0.6424064 
    NA 
    Welch t-test 
    NA 
    TRUE 
    0.6424064 
    0.642 
    Welch t-test 
  
 IL_13 
    continuous 
    label 
    Interleukin 13 
    Interleukin 13 
    1.28 (0.01) 
    1.28 (0.01) 
    0.2577007 
    NA 
    Welch t-test 
    NA 
    TRUE 
    0.2577007 
    0.258 
    Welch t-test 
  
 IL_16 
    continuous 
    label 
    Interleukin 16 
    Interleukin 16 
    2.91 (0.67) 
    2.91 (0.65) 
    0.9601492 
    NA 
    Welch t-test 
    NA 
    TRUE 
    0.9601492 
    0.96 
    Welch t-test 
  
 IL_17E 
    continuous 
    label 
    Interleukin 17E 
    Interleukin 17E 
    4.95 (1.41) 
    4.55 (1.07) 
    0.0057222 
    NA 
    Welch t-test 
    NA 
    TRUE 
    0.0057222 
    0.00572 
    Welch t-test 
  
 IL_1alpha 
    continuous 
    label 
    Interleukin 1 alpha 
    Interleukin 1 alpha 
    -7.54 (0.39) 
    -7.48 (0.43) 
    0.3035679 
    NA 
    Welch t-test 
    NA 
    TRUE 
    0.3035679 
    0.304 
    Welch t-test 
  
 IL_3 
    continuous 
    label 
    Interleukin 3 
    Interleukin 3 
    -3.93 (0.51) 
    -3.99 (0.50) 
    0.4067009 
    NA 
    Welch t-test 
    NA 
    TRUE 
    0.4067009 
    0.407 
    Welch t-test 
  
 IL_4 
    continuous 
    label 
    Interleukin 4 
    Interleukin 4 
    1.78 (0.50) 
    1.72 (0.53) 
    0.3623877 
    NA 
    Welch t-test 
    NA 
    TRUE 
    0.3623877 
    0.362 
    Welch t-test 
  
 IL_5 
    continuous 
    label 
    Interleukin 5 
    Interleukin 5 
    0.21 (0.46) 
    0.17 (0.44) 
    0.4598690 
    NA 
    Welch t-test 
    NA 
    TRUE 
    0.4598690 
    0.46 
    Welch t-test 
  
 IL_6 
    continuous 
    label 
    Interleukin 6 
    Interleukin 6 
    -0.15 (0.51) 
    -0.14 (0.62) 
    0.9841252 
    NA 
    Welch t-test 
    NA 
    TRUE 
    0.9841252 
    0.984 
    Welch t-test 
  
 IL_6_Receptor 
    continuous 
    label 
    Interleukin 6 receptor 
    Interleukin 6 receptor 
    0.09 (0.32) 
    0.08 (0.34) 
    0.8068581 
    NA 
    Welch t-test 
    NA 
    TRUE 
    0.8068581 
    0.807 
    Welch t-test 
  
 IL_7 
    continuous 
    label 
    Interleukin 7 
    Interleukin 7 
    3.01 (0.99) 
    2.61 (1.04) 
    0.0017584 
    NA 
    Welch t-test 
    NA 
    TRUE 
    0.0017584 
    0.00176 
    Welch t-test 
  
 IL_8 
    continuous 
    label 
    Interleukin 8 
    Interleukin 8 
    1.70 (0.03) 
    1.71 (0.04) 
    0.0318468 
    NA 
    Welch t-test 
    NA 
    TRUE 
    0.0318468 
    0.0318 
    Welch t-test 
  
 IP_10_Inducible_Protein_10 
    continuous 
    label 
    Inducible protein 10 
    Inducible protein 10 
    5.69 (0.51) 
    5.85 (0.48) 
    0.0084555 
    NA 
    Welch t-test 
    NA 
    TRUE 
    0.0084555 
    0.00846 
    Welch t-test 
  
 IgA 
    continuous 
    label 
    Immunoglobulin A 
    Immunoglobulin A 
    -6.17 (0.75) 
    -5.94 (0.69) 
    0.0078162 
    NA 
    Welch t-test 
    NA 
    TRUE 
    0.0078162 
    0.00782 
    Welch t-test 
  
 Insulin 
    continuous 
    label 
    Insulin 
    Insulin 
    -1.21 (0.33) 
    -1.26 (0.36) 
    0.2895756 
    NA 
    Welch t-test 
    NA 
    TRUE 
    0.2895756 
    0.29 
    Welch t-test 
  
 Kidney_Injury_Molecule_1_KIM_1 
    continuous 
    label 
    Kidney injury molecule 1 
    Kidney injury molecule 1 
    -1.19 (0.03) 
    -1.18 (0.02) 
    0.0048740 
    NA 
    Welch t-test 
    NA 
    TRUE 
    0.0048740 
    0.00487 
    Welch t-test 
  
 LOX_1 
    continuous 
    label 
    Lectin-like oxidized LDL receptor 1 
    Lectin-like oxidized LDL receptor 1 
    1.27 (0.40) 
    1.27 (0.45) 
    0.9876103 
    NA 
    Welch t-test 
    NA 
    TRUE 
    0.9876103 
    0.988 
    Welch t-test 
  
 Leptin 
    continuous 
    label 
    Leptin 
    Leptin 
    -1.48 (0.27) 
    -1.53 (0.26) 
    0.0940108 
    NA 
    Welch t-test 
    NA 
    TRUE 
    0.0940108 
    0.094 
    Welch t-test 
  
 Lipoprotein_a 
    continuous 
    label 
    Lipoprotein(a) 
    Lipoprotein(a) 
    -4.51 (1.03) 
    -4.25 (1.16) 
    0.0629993 
    NA 
    Welch t-test 
    NA 
    TRUE 
    0.0629993 
    0.063 
    Welch t-test 
  
 MCP_1 
    continuous 
    label 
    Monocyte chemoattractant protein 1 
    Monocyte chemoattractant protein 1 
    6.48 (0.26) 
    6.52 (0.25) 
    0.1775721 
    NA 
    Welch t-test 
    NA 
    TRUE 
    0.1775721 
    0.178 
    Welch t-test 
  
 MCP_2 
    continuous 
    label 
    Monocyte chemoattractant protein 2 
    Monocyte chemoattractant protein 2 
    1.78 (0.62) 
    2.07 (0.64) 
    0.0002487 
    NA 
    Welch t-test 
    NA 
    TRUE 
    0.0002487 
    <0.001 
    Welch t-test 
  
 MIF 
    continuous 
    label 
    Macrophage migration inhibitory factor 
    Macrophage migration inhibitory factor 
    -1.93 (0.33) 
    -1.74 (0.29) 
    0.0000004 
    NA 
    Welch t-test 
    NA 
    TRUE 
    0.0000004 
    <0.001 
    Welch t-test 
  
 MIP_1alpha 
    continuous 
    label 
    Macrophage inflammatory protein 1 alpha 
    Macrophage inflammatory protein 1 alpha 
    3.94 (1.05) 
    4.24 (0.88) 
    0.0083499 
    NA 
    Welch t-test 
    NA 
    TRUE 
    0.0083499 
    0.00835 
    Welch t-test 
  
 MIP_1beta 
    continuous 
    label 
    Macrophage inflammatory protein 1 beta 
    Macrophage inflammatory protein 1 beta 
    2.79 (0.38) 
    2.87 (0.40) 
    0.0869483 
    NA 
    Welch t-test 
    NA 
    TRUE 
    0.0869483 
    0.0869 
    Welch t-test 
  
 MMP_2 
    continuous 
    label 
    Matrix metalloproteinase 2 
    Matrix metalloproteinase 2 
    2.95 (0.95) 
    2.81 (0.89) 
    0.2122963 
    NA 
    Welch t-test 
    NA 
    TRUE 
    0.2122963 
    0.212 
    Welch t-test 
  
 MMP_3 
    continuous 
    label 
    Matrix metalloproteinase 3 
    Matrix metalloproteinase 3 
    -2.49 (0.56) 
    -2.36 (0.60) 
    0.0738423 
    NA 
    Welch t-test 
    NA 
    TRUE 
    0.0738423 
    0.0738 
    Welch t-test 
  
 MMP10 
    continuous 
    label 
    Matrix metalloproteinase 10 
    Matrix metalloproteinase 10 
    -3.73 (0.40) 
    -3.42 (0.44) 
    0.0000000 
    NA 
    Welch t-test 
    NA 
    TRUE 
    0.0000000 
    <0.001 
    Welch t-test 
  
 MMP7 
    continuous 
    label 
    Matrix metalloproteinase 7 
    Matrix metalloproteinase 7 
    -4.07 (1.58) 
    -3.21 (1.28) 
    0.0000009 
    NA 
    Welch t-test 
    NA 
    TRUE 
    0.0000009 
    <0.001 
    Welch t-test 
  
 Myoglobin 
    continuous 
    label 
    Myoglobin 
    Myoglobin 
    -1.43 (0.96) 
    -1.23 (0.87) 
    0.0755465 
    NA 
    Welch t-test 
    NA 
    TRUE 
    0.0755465 
    0.0755 
    Welch t-test 
  
 NT_proBNP 
    continuous 
    label 
    N-terminal pro b-type natriuretic peptide 
    N-terminal pro b-type natriuretic peptide 
    4.46 (0.36) 
    4.71 (0.36) 
    0.0000038 
    NA 
    Welch t-test 
    NA 
    TRUE 
    0.0000038 
    <0.001 
    Welch t-test 
  
 NrCAM 
    continuous 
    label 
    Neuron-glia cell adhesion molecule 
    Neuron-glia cell adhesion molecule 
    4.38 (0.56) 
    4.33 (0.54) 
    0.5219452 
    NA 
    Welch t-test 
    NA 
    TRUE 
    0.5219452 
    0.522 
    Welch t-test 
  
 Osteopontin 
    continuous 
    label 
    Osteopontin 
    Osteopontin 
    5.16 (0.38) 
    5.31 (0.41) 
    0.0022081 
    NA 
    Welch t-test 
    NA 
    TRUE 
    0.0022081 
    0.00221 
    Welch t-test 
  
 PAI_1 
    continuous 
    label 
    Plasminogen activator inhibitor 1 
    Plasminogen activator inhibitor 1 
    -0.01 (0.38) 
    0.26 (0.44) 
    0.0000007 
    NA 
    Welch t-test 
    NA 
    TRUE 
    0.0000007 
    <0.001 
    Welch t-test 
  
 PAPP_A 
    continuous 
    label 
    Pregnancy-associated plasma protein A 
    Pregnancy-associated plasma protein A 
    -2.85 (0.14) 
    -2.85 (0.14) 
    0.9612735 
    NA 
    Welch t-test 
    NA 
    TRUE 
    0.9612735 
    0.961 
    Welch t-test 
  
 PLGF 
    continuous 
    label 
    Placental growth factor 
    Placental growth factor 
    3.87 (0.39) 
    4.01 (0.42) 
    0.0045508 
    NA 
    Welch t-test 
    NA 
    TRUE 
    0.0045508 
    0.00455 
    Welch t-test 
  
 PYY 
    continuous 
    label 
    Peptide YY 
    Peptide YY 
    3.01 (0.29) 
    3.01 (0.28) 
    0.8747602 
    NA 
    Welch t-test 
    NA 
    TRUE 
    0.8747602 
    0.875 
    Welch t-test 
  
 Pancreatic_polypeptide 
    continuous 
    label 
    Pancreatic polypeptide 
    Pancreatic polypeptide 
    -0.14 (0.67) 
    0.32 (0.74) 
    0.0000008 
    NA 
    Welch t-test 
    NA 
    TRUE 
    0.0000008 
    <0.001 
    Welch t-test 
  
 Prolactin 
    continuous 
    label 
    Prolactin 
    Prolactin 
    0.03 (0.30) 
    0.09 (0.27) 
    0.1059084 
    NA 
    Welch t-test 
    NA 
    TRUE 
    0.1059084 
    0.106 
    Welch t-test 
  
 Prostatic_Acid_Phosphatase 
    continuous 
    label 
    Prostatic acid phosphatase 
    Prostatic acid phosphatase 
    -1.69 (0.06) 
    -1.68 (0.06) 
    0.0631539 
    NA 
    Welch t-test 
    NA 
    TRUE 
    0.0631539 
    0.0632 
    Welch t-test 
  
 Protein_S 
    continuous 
    label 
    Protein S 
    Protein S 
    -2.27 (0.36) 
    -2.17 (0.37) 
    0.0181327 
    NA 
    Welch t-test 
    NA 
    TRUE 
    0.0181327 
    0.0181 
    Welch t-test 
  
 Pulmonary_and_Activation_Regulat 
    continuous 
    label 
    Pulmonary and activation-regulated chemokine 
    Pulmonary and activation-regulated chemokine 
    -1.56 (0.47) 
    -1.47 (0.35) 
    0.1259992 
    NA 
    Welch t-test 
    NA 
    TRUE 
    0.1259992 
    0.126 
    Welch t-test 
  
 RANTES 
    continuous 
    label 
    Regulated on activation, normal T cell expressed and secreted 
    Regulated on activation, normal T cell expressed and secreted 
    -6.55 (0.31) 
    -6.44 (0.31) 
    0.0044494 
    NA 
    Welch t-test 
    NA 
    TRUE 
    0.0044494 
    0.00445 
    Welch t-test 
  
 Resistin 
    continuous 
    label 
    Resistin 
    Resistin 
    -18.52 (5.42) 
    -15.74 (5.93) 
    0.0001487 
    NA 
    Welch t-test 
    NA 
    TRUE 
    0.0001487 
    <0.001 
    Welch t-test 
  
 S100b 
    continuous 
    label 
    S100 calcium-binding protein B 
    S100 calcium-binding protein B 
    1.21 (0.35) 
    1.32 (0.34) 
    0.0078991 
    NA 
    Welch t-test 
    NA 
    TRUE 
    0.0078991 
    0.0079 
    Welch t-test 
  
 SGOT 
    continuous 
    label 
    Serum glutamic-oxaloacetic transaminase 
    Serum glutamic-oxaloacetic transaminase 
    -0.44 (0.37) 
    -0.37 (0.29) 
    0.0469909 
    NA 
    Welch t-test 
    NA 
    TRUE 
    0.0469909 
    0.047 
    Welch t-test 
  
 SHBG 
    continuous 
    label 
    Sex hormone-binding globulin 
    Sex hormone-binding globulin 
    -2.54 (0.57) 
    -2.45 (0.56) 
    0.1686214 
    NA 
    Welch t-test 
    NA 
    TRUE 
    0.1686214 
    0.169 
    Welch t-test 
  
 SOD 
    continuous 
    label 
    Superoxide dismutase 
    Superoxide dismutase 
    5.31 (0.38) 
    5.39 (0.38) 
    0.0833871 
    NA 
    Welch t-test 
    NA 
    TRUE 
    0.0833871 
    0.0834 
    Welch t-test 
  
 Serum_Amyloid_P 
    continuous 
    label 
    Serum amyloid P component 
    Serum amyloid P component 
    -6.05 (0.55) 
    -5.98 (0.57) 
    0.3236618 
    NA 
    Welch t-test 
    NA 
    TRUE 
    0.3236618 
    0.324 
    Welch t-test 
  
 Sortilin 
    continuous 
    label 
    Sortilin 
    Sortilin 
    3.74 (0.86) 
    4.10 (0.83) 
    0.0005339 
    NA 
    Welch t-test 
    NA 
    TRUE 
    0.0005339 
    <0.001 
    Welch t-test 
  
 Stem_Cell_Factor 
    continuous 
    label 
    Stem cell factor 
    Stem cell factor 
    3.30 (0.36) 
    3.28 (0.34) 
    0.6843984 
    NA 
    Welch t-test 
    NA 
    TRUE 
    0.6843984 
    0.684 
    Welch t-test 
  
 TGF_alpha 
    continuous 
    label 
    Transforming growth factor alpha 
    Transforming growth factor alpha 
    9.73 (1.31) 
    9.96 (1.18) 
    0.1283139 
    NA 
    Welch t-test 
    NA 
    TRUE 
    0.1283139 
    0.128 
    Welch t-test 
  
 TIMP_1 
    continuous 
    label 
    Tissue inhibitor of metalloproteinases 1 
    Tissue inhibitor of metalloproteinases 1 
    11.55 (1.78) 
    12.11 (1.97) 
    0.0209928 
    NA 
    Welch t-test 
    NA 
    TRUE 
    0.0209928 
    0.021 
    Welch t-test 
  
 TNF_RII 
    continuous 
    label 
    Tumor necrosis factor receptor II 
    Tumor necrosis factor receptor II 
    -0.64 (0.32) 
    -0.48 (0.35) 
    0.0002205 
    NA 
    Welch t-test 
    NA 
    TRUE 
    0.0002205 
    <0.001 
    Welch t-test 
  
 TRAIL_R3 
    continuous 
    label 
    TNF-related apoptosis-inducing ligand receptor 3 
    TNF-related apoptosis-inducing ligand receptor 3 
    -0.59 (0.23) 
    -0.43 (0.23) 
    0.0000001 
    NA 
    Welch t-test 
    NA 
    TRUE 
    0.0000001 
    <0.001 
    Welch t-test 
  
 TTR_prealbumin 
    continuous 
    label 
    Transthyretin (prealbumin) 
    Transthyretin (prealbumin) 
    2.86 (0.14) 
    2.84 (0.14) 
    0.4396330 
    NA 
    Welch t-test 
    NA 
    TRUE 
    0.4396330 
    0.44 
    Welch t-test 
  
 Tamm_Horsfall_Protein_THP 
    continuous 
    label 
    Tamm-Horsfall protein 
    Tamm-Horsfall protein 
    -3.12 (0.03) 
    -3.11 (0.03) 
    0.3283328 
    NA 
    Welch t-test 
    NA 
    TRUE 
    0.3283328 
    0.328 
    Welch t-test 
  
 Thrombomodulin 
    continuous 
    label 
    Thrombomodulin 
    Thrombomodulin 
    -1.53 (0.23) 
    -1.45 (0.22) 
    0.0028089 
    NA 
    Welch t-test 
    NA 
    TRUE 
    0.0028089 
    0.00281 
    Welch t-test 
  
 Thrombopoietin 
    continuous 
    label 
    Thrombopoietin 
    Thrombopoietin 
    -0.74 (0.24) 
    -0.81 (0.25) 
    0.0630863 
    NA 
    Welch t-test 
    NA 
    TRUE 
    0.0630863 
    0.0631 
    Welch t-test 
  
 Thymus_Expressed_Chemokine_TECK 
    continuous 
    label 
    Thymus-expressed chemokine (TECK) 
    Thymus-expressed chemokine (TECK) 
    3.73 (0.77) 
    4.11 (0.76) 
    0.0000606 
    NA 
    Welch t-test 
    NA 
    TRUE 
    0.0000606 
    <0.001 
    Welch t-test 
  
 Thyroid_Stimulating_Hormone 
    continuous 
    label 
    Thyroid-stimulating hormone 
    Thyroid-stimulating hormone 
    -4.45 (0.75) 
    -4.43 (0.82) 
    0.8817515 
    NA 
    Welch t-test 
    NA 
    TRUE 
    0.8817515 
    0.882 
    Welch t-test 
  
 Thyroxine_Binding_Globulin 
    continuous 
    label 
    Thyroxine-binding globulin 
    Thyroxine-binding globulin 
    -1.51 (0.40) 
    -1.42 (0.39) 
    0.0668355 
    NA 
    Welch t-test 
    NA 
    TRUE 
    0.0668355 
    0.0668 
    Welch t-test 
  
 Tissue_Factor 
    continuous 
    label 
    Tissue factor 
    Tissue factor 
    1.16 (0.51) 
    1.18 (0.51) 
    0.7382965 
    NA 
    Welch t-test 
    NA 
    TRUE 
    0.7382965 
    0.738 
    Welch t-test 
  
 Transferrin 
    continuous 
    label 
    Transferrin 
    Transferrin 
    2.90 (0.28) 
    2.92 (0.27) 
    0.5677089 
    NA 
    Welch t-test 
    NA 
    TRUE 
    0.5677089 
    0.568 
    Welch t-test 
  
 Trefoil_Factor_3_TFF3 
    continuous 
    label 
    Trefoil factor 3 (TFF3) 
    Trefoil factor 3 (TFF3) 
    -3.90 (0.33) 
    -3.85 (0.36) 
    0.2500022 
    NA 
    Welch t-test 
    NA 
    TRUE 
    0.2500022 
    0.25 
    Welch t-test 
  
 VCAM_1 
    continuous 
    label 
    Vascular cell adhesion molecule 1 
    Vascular cell adhesion molecule 1 
    2.66 (0.30) 
    2.73 (0.37) 
    0.0887835 
    NA 
    Welch t-test 
    NA 
    TRUE 
    0.0887835 
    0.0888 
    Welch t-test 
  
 VEGF 
    continuous 
    label 
    Vascular endothelial growth factor 
    Vascular endothelial growth factor 
    17.14 (1.85) 
    16.37 (1.83) 
    0.0008075 
    NA 
    Welch t-test 
    NA 
    TRUE 
    0.0008075 
    <0.001 
    Welch t-test 
  
 Vitronectin 
    continuous 
    label 
    Vitronectin 
    Vitronectin 
    -0.28 (0.33) 
    -0.28 (0.32) 
    0.9569334 
    NA 
    Welch t-test 
    NA 
    TRUE 
    0.9569334 
    0.957 
    Welch t-test 
  
 von_Willebrand_Factor 
    continuous 
    label 
    von Willebrand factor 
    von Willebrand factor 
    -3.95 (0.37) 
    -3.86 (0.39) 
    0.0473700 
    NA 
    Welch t-test 
    NA 
    TRUE 
    0.0473700 
    0.0474 
    Welch t-test 
  
 tau 
    continuous 
    label 
    Tau protein 
    Tau protein 
    5.61 (0.49) 
    6.14 (0.55) 
    0.0000000 
    NA 
    Welch t-test 
    NA 
    TRUE 
    0.0000000 
    <0.001 
    Welch t-test 
  
 p_tau 
    continuous 
    label 
    Phosphorylated tau protein 
    Phosphorylated tau protein 
    3.94 (0.42) 
    4.30 (0.48) 
    0.0000000 
    NA 
    Welch t-test 
    NA 
    TRUE 
    0.0000000 
    <0.001 
    Welch t-test 
  
 Ab_42 
    continuous 
    label 
    Amyloid beta 42 
    Amyloid beta 42 
    12.80 (1.41) 
    11.27 (1.34) 
    0.0000000 
    NA 
    Welch t-test 
    NA 
    TRUE 
    0.0000000 
    <0.001 
    Welch t-test 
  
 age 
    continuous 
    label 
    Age 
    Age 
    72.75 (13.26) 
    71.78 (13.12) 
    0.5526369 
    NA 
    Welch t-test 
    NA 
    TRUE 
    0.5526369 
    0.553 
    Welch t-test 
  
 sex 
    categorical 
    label 
    Sex 
    Sex 
    NA 
    NA 
    0.0272353 
    NA 
    Pearson chi-squared 
    NA 
    TRUE 
    0.0272353 
    0.0272 
    Pearson chi-squared 
  
 sex 
    categorical 
    level 
    Sex 
    Female 
    157 (65%) 
    47 (52%) 
    0.0272353 
    NA 
    Pearson chi-squared 
    NA 
    FALSE 
    0.0272353 
    NA 
    NA 
  
 sex 
    categorical 
    level 
    Sex 
    Male 
    85 (35%) 
    44 (48%) 
    0.0272353 
    NA 
    Pearson chi-squared 
    NA 
    FALSE 
    0.0272353 
    NA 
    NA 
  
 Genotype 
    categorical 
    label 
    Genotype 
    Genotype 
    NA 
    NA 
    0.0005999 
    NA 
    Fisher (sim.) 
    NA 
    TRUE 
    0.0005999 
    <0.001 
    Fisher (sim.) 
  
 Genotype 
    categorical 
    level 
    Genotype 
    E2E2 
    2 (0.8%) 
    0 (0%) 
    0.0005999 
    NA 
    Fisher (sim.) 
    NA 
    FALSE 
    0.0005999 
    NA 
    NA 
  
 Genotype 
    categorical 
    level 
    Genotype 
    E2E3 
    30 (12%) 
    7 (7.7%) 
    0.0005999 
    NA 
    Fisher (sim.) 
    NA 
    FALSE 
    0.0005999 
    NA 
    NA 
  
 Genotype 
    categorical 
    level 
    Genotype 
    E2E4 
    7 (2.9%) 
    1 (1.1%) 
    0.0005999 
    NA 
    Fisher (sim.) 
    NA 
    FALSE 
    0.0005999 
    NA 
    NA 
  
 Genotype 
    categorical 
    level 
    Genotype 
    E3E3 
    133 (55%) 
    34 (37%) 
    0.0005999 
    NA 
    Fisher (sim.) 
    NA 
    FALSE 
    0.0005999 
    NA 
    NA 
  
 Genotype 
    categorical 
    level 
    Genotype 
    E3E4 
    65 (27%) 
    41 (45%) 
    0.0005999 
    NA 
    Fisher (sim.) 
    NA 
    FALSE 
    0.0005999 
    NA 
    NA 
  
 Genotype 
    categorical 
    level 
    Genotype 
    E4E4 
    5 (2.1%) 
    8 (8.8%) 
    0.0005999 
    NA 
    Fisher (sim.) 
    NA 
    FALSE 
    0.0005999 
    NA 
    NA 
  
 ACE_CD143_Angiotensin_Converti 
    continuous 
    label 
    Angiotensin-converting enzyme 
    Angiotensin-converting enzyme 
    1.32 (0.56) 
    1.31 (0.53) 
    0.8846265 
    NA 
    Welch t-test 
    NA 
    TRUE 
    0.8846265 
    0.885 
    Welch t-test 
  
 ACTH_Adrenocorticotropic_Hormon 
    continuous 
    label 
    Adrenocorticotropic hormone 
    Adrenocorticotropic hormone 
    -1.55 (0.27) 
    -1.51 (0.29) 
    0.3228133 
    NA 
    Welch t-test 
    NA 
    TRUE 
    0.3228133 
    0.323 
    Welch t-test 
  
 AXL 
    continuous 
    label 
    AXL receptor tyrosine kinase 
    AXL receptor tyrosine kinase 
    0.28 (0.46) 
    0.34 (0.41) 
    0.2384182 
    NA 
    Welch t-test 
    NA 
    TRUE 
    0.2384182 
    0.238 
    Welch t-test 
  
 Adiponectin 
    continuous 
    label 
    Adiponectin 
    Adiponectin 
    -5.26 (0.65) 
    -5.10 (0.69) 
    0.0538971 
    NA 
    Welch t-test 
    NA 
    TRUE 
    0.0538971 
    0.0539 
    Welch t-test 
  
 Alpha_1_Antichymotrypsin 
    continuous 
    label 
    Alpha-1-antichymotrypsin 
    Alpha-1-antichymotrypsin 
    1.32 (0.36) 
    1.44 (0.37) 
    0.0096393 
    NA 
    Welch t-test 
    NA 
    TRUE 
    0.0096393 
    0.00964 
    Welch t-test 
  
 Alpha_1_Antitrypsin 
    continuous 
    label 
    Alpha-1-antitrypsin 
    Alpha-1-antitrypsin 
    -13.33 (1.51) 
    -12.62 (1.52) 
    0.0001841 
    NA 
    Welch t-test 
    NA 
    TRUE 
    0.0001841 
    <0.001 
    Welch t-test 
  
 Alpha_1_Microglobulin 
    continuous 
    label 
    Alpha-1-microglobulin 
    Alpha-1-microglobulin 
    -2.99 (0.48) 
    -2.82 (0.45) 
    0.0030400 
    NA 
    Welch t-test 
    NA 
    TRUE 
    0.0030400 
    0.00304 
    Welch t-test 
  
 Alpha_2_Macroglobulin 
    continuous 
    label 
    Alpha-2-macroglobulin 
    Alpha-2-macroglobulin 
    -162.49 (41.36) 
    -151.41 (38.78) 
    0.0237020 
    NA 
    Welch t-test 
    NA 
    TRUE 
    0.0237020 
    0.0237 
    Welch t-test 
  
 Angiopoietin_2_ANG_2 
    continuous 
    label 
    Angiopoietin-2 
    Angiopoietin-2 
    0.65 (0.33) 
    0.70 (0.34) 
    0.2243927 
    NA 
    Welch t-test 
    NA 
    TRUE 
    0.2243927 
    0.224 
    Welch t-test 
  
 Angiotensinogen 
    continuous 
    label 
    Angiotensinogen 
    Angiotensinogen 
    2.31 (0.25) 
    2.38 (0.25) 
    0.0363220 
    NA 
    Welch t-test 
    NA 
    TRUE 
    0.0363220 
    0.0363 
    Welch t-test 
  
 Apolipoprotein_A_IV 
    continuous 
    label 
    Apolipoprotein A-IV 
    Apolipoprotein A-IV 
    -1.86 (0.39) 
    -1.84 (0.37) 
    0.6196039 
    NA 
    Welch t-test 
    NA 
    TRUE 
    0.6196039 
    0.62 
    Welch t-test 
  
 Apolipoprotein_A1 
    continuous 
    label 
    Apolipoprotein A-1 
    Apolipoprotein A-1 
    -7.48 (0.43) 
    -7.50 (0.44) 
    0.6901145 
    NA 
    Welch t-test 
    NA 
    TRUE 
    0.6901145 
    0.69 
    Welch t-test 
  
 Apolipoprotein_A2 
    continuous 
    label 
    Apolipoprotein A-2 
    Apolipoprotein A-2 
    -0.66 (0.50) 
    -0.61 (0.48) 
    0.3909281 
    NA 
    Welch t-test 
    NA 
    TRUE 
    0.3909281 
    0.391 
    Welch t-test 
  
 Apolipoprotein_B 
    continuous 
    label 
    Apolipoprotein B 
    Apolipoprotein B 
    -5.71 (1.40) 
    -5.27 (1.55) 
    0.0183210 
    NA 
    Welch t-test 
    NA 
    TRUE 
    0.0183210 
    0.0183 
    Welch t-test 
  
 Apolipoprotein_CI 
    continuous 
    label 
    Apolipoprotein C-I 
    Apolipoprotein C-I 
    -1.60 (0.41) 
    -1.58 (0.45) 
    0.8186647 
    NA 
    Welch t-test 
    NA 
    TRUE 
    0.8186647 
    0.819 
    Welch t-test 
  
 Apolipoprotein_CIII 
    continuous 
    label 
    Apolipoprotein C-III 
    Apolipoprotein C-III 
    -2.53 (0.44) 
    -2.42 (0.44) 
    0.0350373 
    NA 
    Welch t-test 
    NA 
    TRUE 
    0.0350373 
    0.035 
    Welch t-test 
  
 Apolipoprotein_D 
    continuous 
    label 
    Apolipoprotein D 
    Apolipoprotein D 
    1.39 (0.33) 
    1.54 (0.38) 
    0.0015555 
    NA 
    Welch t-test 
    NA 
    TRUE 
    0.0015555 
    0.00156 
    Welch t-test 
  
 Apolipoprotein_E 
    continuous 
    label 
    Apolipoprotein E 
    Apolipoprotein E 
    2.79 (0.77) 
    2.78 (0.87) 
    0.8668217 
    NA 
    Welch t-test 
    NA 
    TRUE 
    0.8668217 
    0.867 
    Welch t-test 
  
 Apolipoprotein_H 
    continuous 
    label 
    Apolipoprotein H 
    Apolipoprotein H 
    -0.35 (0.38) 
    -0.23 (0.38) 
    0.0106232 
    NA 
    Welch t-test 
    NA 
    TRUE 
    0.0106232 
    0.0106 
    Welch t-test 
  
 B_Lymphocyte_Chemoattractant_BL 
    continuous 
    label 
    B-lymphocyte chemoattractant 
    B-lymphocyte chemoattractant 
    1.92 (0.57) 
    2.16 (0.56) 
    0.0007177 
    NA 
    Welch t-test 
    NA 
    TRUE 
    0.0007177 
    <0.001 
    Welch t-test 
  
 BMP_6 
    continuous 
    label 
    Bone morphogenetic protein 6 
    Bone morphogenetic protein 6 
    -1.89 (0.29) 
    -1.92 (0.33) 
    0.5218752 
    NA 
    Welch t-test 
    NA 
    TRUE 
    0.5218752 
    0.522 
    Welch t-test 
  
 Beta_2_Microglobulin 
    continuous 
    label 
    Beta-2-microglobulin 
    Beta-2-microglobulin 
    0.16 (0.29) 
    0.19 (0.31) 
    0.4233981 
    NA 
    Welch t-test 
    NA 
    TRUE 
    0.4233981 
    0.423 
    Welch t-test 
  
 Betacellulin 
    continuous 
    label 
    Betacellulin 
    Betacellulin 
    51.63 (10.91) 
    50.62 (10.60) 
    0.4399492 
    NA 
    Welch t-test 
    NA 
    TRUE 
    0.4399492 
    0.44 
    Welch t-test 
  
 C_Reactive_Protein 
    continuous 
    label 
    C-reactive protein 
    C-reactive protein 
    -5.87 (1.22) 
    -5.97 (1.14) 
    0.4843525 
    NA 
    Welch t-test 
    NA 
    TRUE 
    0.4843525 
    0.484 
    Welch t-test 
  
 CD40 
    continuous 
    label 
    CD40 
    CD40 
    -1.26 (0.21) 
    -1.28 (0.24) 
    0.5003297 
    NA 
    Welch t-test 
    NA 
    TRUE 
    0.5003297 
    0.5 
    Welch t-test 
  
 CD5L 
    continuous 
    label 
    CD5L 
    CD5L 
    -0.10 (0.44) 
    0.04 (0.49) 
    0.0247260 
    NA 
    Welch t-test 
    NA 
    TRUE 
    0.0247260 
    0.0247 
    Welch t-test 
  
 Calbindin 
    continuous 
    label 
    Calbindin 
    Calbindin 
    21.99 (3.90) 
    22.93 (4.85) 
    0.1011017 
    NA 
    Welch t-test 
    NA 
    TRUE 
    0.1011017 
    0.101 
    Welch t-test 
  
 Calcitonin 
    continuous 
    label 
    Calcitonin 
    Calcitonin 
    1.68 (0.85) 
    1.71 (0.94) 
    0.7808643 
    NA 
    Welch t-test 
    NA 
    TRUE 
    0.7808643 
    0.781 
    Welch t-test 
  
 CgA 
    continuous 
    label 
    Chromogranin A 
    Chromogranin A 
    329.78 (82.65) 
    333.17 (81.12) 
    0.7351867 
    NA 
    Welch t-test 
    NA 
    TRUE 
    0.7351867 
    0.735 
    Welch t-test 
  
 Clusterin_Apo_J 
    continuous 
    label 
    Clusterin (ApoJ) 
    Clusterin (ApoJ) 
    2.85 (0.29) 
    2.95 (0.33) 
    0.0116372 
    NA 
    Welch t-test 
    NA 
    TRUE 
    0.0116372 
    0.0116 
    Welch t-test 
  
 Complement_3 
    continuous 
    label 
    Complement component 3 
    Complement component 3 
    -15.95 (2.45) 
    -14.92 (2.43) 
    0.0007632 
    NA 
    Welch t-test 
    NA 
    TRUE 
    0.0007632 
    <0.001 
    Welch t-test 
  
 Complement_Factor_H 
    continuous 
    label 
    Complement factor H 
    Complement factor H 
    3.48 (1.26) 
    3.62 (1.22) 
    0.3580892 
    NA 
    Welch t-test 
    NA 
    TRUE 
    0.3580892 
    0.358 
    Welch t-test 
  
 Connective_Tissue_Growth_Factor 
    continuous 
    label 
    Connective tissue growth factor 
    Connective tissue growth factor 
    0.76 (0.21) 
    0.79 (0.20) 
    0.2752610 
    NA 
    Welch t-test 
    NA 
    TRUE 
    0.2752610 
    0.275 
    Welch t-test 
  
 Cortisol 
    continuous 
    label 
    Cortisol 
    Cortisol 
    11.22 (3.73) 
    12.93 (4.34) 
    0.0011179 
    NA 
    Welch t-test 
    NA 
    TRUE 
    0.0011179 
    0.00112 
    Welch t-test 
  
 Creatine_Kinase_MB 
    continuous 
    label 
    Creatine kinase-MB 
    Creatine kinase-MB 
    -1.66 (0.10) 
    -1.70 (0.08) 
    0.0001039 
    NA 
    Welch t-test 
    NA 
    TRUE 
    0.0001039 
    <0.001 
    Welch t-test 
  
 Cystatin_C 
    continuous 
    label 
    Cystatin C 
    Cystatin C 
    8.62 (0.40) 
    8.48 (0.40) 
    0.0055073 
    NA 
    Welch t-test 
    NA 
    TRUE 
    0.0055073 
    0.00551 
    Welch t-test 
  
 EGF_R 
    continuous 
    label 
    Epidermal growth factor receptor 
    Epidermal growth factor receptor 
    -0.71 (0.24) 
    -0.68 (0.22) 
    0.4379144 
    NA 
    Welch t-test 
    NA 
    TRUE 
    0.4379144 
    0.438 
    Welch t-test 
  
 EN_RAGE 
    continuous 
    label 
    EN-RAGE (extracellular newly identified RAGE-binding protein) 
    EN-RAGE (extracellular newly identified RAGE-binding protein) 
    -3.62 (0.90) 
    -3.65 (0.88) 
    0.7659387 
    NA 
    Welch t-test 
    NA 
    TRUE 
    0.7659387 
    0.766 
    Welch t-test 
  
 ENA_78 
    continuous 
    label 
    ENA-78 (epithelial-derived neutrophil-activating protein 78) 
    ENA-78 (epithelial-derived neutrophil-activating protein 78) 
    -1.37 (0.01) 
    -1.37 (0.01) 
    0.9254390 
    NA 
    Welch t-test 
    NA 
    TRUE 
    0.9254390 
    0.925 
    Welch t-test 
  
 Eotaxin_3 
    continuous 
    label 
    Eotaxin-3 
    Eotaxin-3 
    55.36 (15.98) 
    63.75 (15.86) 
    0.0000303 
    NA 
    Welch t-test 
    NA 
    TRUE 
    0.0000303 
    <0.001 
    Welch t-test 
  
 FAS 
    continuous 
    label 
    Fas (tumor necrosis factor receptor superfamily member 6) 
    Fas (tumor necrosis factor receptor superfamily member 6) 
    -0.58 (0.28) 
    -0.40 (0.31) 
    0.0000019 
    NA 
    Welch t-test 
    NA 
    TRUE 
    0.0000019 
    <0.001 
    Welch t-test 
  
 FSH_Follicle_Stimulation_Hormon 
    continuous 
    label 
    Follicle-stimulating hormone 
    Follicle-stimulating hormone 
    -1.12 (0.39) 
    -1.15 (0.43) 
    0.6164374 
    NA 
    Welch t-test 
    NA 
    TRUE 
    0.6164374 
    0.616 
    Welch t-test 
  
 Fas_Ligand 
    continuous 
    label 
    Fas ligand 
    Fas ligand 
    2.79 (1.05) 
    3.22 (1.12) 
    0.0015514 
    NA 
    Welch t-test 
    NA 
    TRUE 
    0.0015514 
    0.00155 
    Welch t-test 
  
 Fatty_Acid_Binding_Protein 
    continuous 
    label 
    Fatty acid-binding protein 
    Fatty acid-binding protein 
    1.24 (0.73) 
    1.59 (0.86) 
    0.0007710 
    NA 
    Welch t-test 
    NA 
    TRUE 
    0.0007710 
    <0.001 
    Welch t-test 
  
 Ferritin 
    continuous 
    label 
    Ferritin 
    Ferritin 
    2.70 (0.76) 
    2.90 (0.83) 
    0.0426440 
    NA 
    Welch t-test 
    NA 
    TRUE 
    0.0426440 
    0.0426 
    Welch t-test 
  
 Fetuin_A 
    continuous 
    label 
    Fetuin-A 
    Fetuin-A 
    1.32 (0.40) 
    1.44 (0.34) 
    0.0314522 
    NA 
    Welch t-test 
    NA 
    TRUE 
    0.0314522 
    0.0315 
    Welch t-test 
  
 Fibrinogen 
    continuous 
    label 
    Fibrinogen 
    Fibrinogen 
    -7.45 (0.56) 
    -7.12 (0.57) 
    0.0000075 
    NA 
    Welch t-test 
    NA 
    TRUE 
    0.0000075 
    <0.001 
    Welch t-test 
  
 GRO_alpha 
    continuous 
    label 
    Growth-regulated alpha protein 
    Growth-regulated alpha protein 
    1.37 (0.04) 
    1.40 (0.04) 
    0.0000000 
    NA 
    Welch t-test 
    NA 
    TRUE 
    0.0000000 
    <0.001 
    Welch t-test 
  
 Gamma_Interferon_induced_Monokin 
    continuous 
    label 
    Gamma interferon-induced monokine 
    Gamma interferon-induced monokine 
    2.77 (0.11) 
    2.83 (0.10) 
    0.0000059 
    NA 
    Welch t-test 
    NA 
    TRUE 
    0.0000059 
    <0.001 
    Welch t-test 
  
 Glutathione_S_Transferase_alpha 
    continuous 
    label 
    Glutathione S-transferase alpha 
    Glutathione S-transferase alpha 
    0.95 (0.17) 
    0.96 (0.12) 
    0.5459600 
    NA 
    Welch t-test 
    NA 
    TRUE 
    0.5459600 
    0.546 
    Welch t-test 
  
 HB_EGF 
    continuous 
    label 
    Heparin-binding epidermal growth factor 
    Heparin-binding epidermal growth factor 
    6.70 (1.47) 
    7.20 (1.49) 
    0.0061319 
    NA 
    Welch t-test 
    NA 
    TRUE 
    0.0061319 
    0.00613 
    Welch t-test 
  
 HCC_4 
    continuous 
    label 
    HCC-4 (hemofiltrate CC chemokine-4) 
    HCC-4 (hemofiltrate CC chemokine-4) 
    -3.55 (0.36) 
    -3.40 (0.34) 
    0.0005695 
    NA 
    Welch t-test 
    NA 
    TRUE 
    0.0005695 
    <0.001 
    Welch t-test 
  
 Hepatocyte_Growth_Factor_HGF 
    continuous 
    label 
    Hepatocyte growth factor 
    Hepatocyte growth factor 
    0.17 (0.29) 
    0.27 (0.29) 
    0.0051215 
    NA 
    Welch t-test 
    NA 
    TRUE 
    0.0051215 
    0.00512 
    Welch t-test 
  
 I_309 
    continuous 
    label 
    I-309 (TCA-3) 
    I-309 (TCA-3) 
    2.92 (0.36) 
    3.02 (0.39) 
    0.0337660 
    NA 
    Welch t-test 
    NA 
    TRUE 
    0.0337660 
    0.0338 
    Welch t-test 
  
 ICAM_1 
    continuous 
    label 
    Intercellular adhesion molecule 1 
    Intercellular adhesion molecule 1 
    -0.60 (0.32) 
    -0.56 (0.36) 
    0.3368872 
    NA 
    Welch t-test 
    NA 
    TRUE 
    0.3368872 
    0.337 
    Welch t-test 
  
 IGF_BP_2 
    continuous 
    label 
    Insulin-like growth factor-binding protein 2 
    Insulin-like growth factor-binding protein 2 
    5.28 (0.20) 
    5.38 (0.22) 
    0.0001243 
    NA 
    Welch t-test 
    NA 
    TRUE 
    0.0001243 
    <0.001 
    Welch t-test 
  
 IL_11 
    continuous 
    label 
    Interleukin 11 
    Interleukin 11 
    4.73 (1.39) 
    4.65 (1.53) 
    0.6424064 
    NA 
    Welch t-test 
    NA 
    TRUE 
    0.6424064 
    0.642 
    Welch t-test 
  
 IL_13 
    continuous 
    label 
    Interleukin 13 
    Interleukin 13 
    1.28 (0.01) 
    1.28 (0.01) 
    0.2577007 
    NA 
    Welch t-test 
    NA 
    TRUE 
    0.2577007 
    0.258 
    Welch t-test 
  
 IL_16 
    continuous 
    label 
    Interleukin 16 
    Interleukin 16 
    2.91 (0.67) 
    2.91 (0.65) 
    0.9601492 
    NA 
    Welch t-test 
    NA 
    TRUE 
    0.9601492 
    0.96 
    Welch t-test 
  
 IL_17E 
    continuous 
    label 
    Interleukin 17E 
    Interleukin 17E 
    4.95 (1.41) 
    4.55 (1.07) 
    0.0057222 
    NA 
    Welch t-test 
    NA 
    TRUE 
    0.0057222 
    0.00572 
    Welch t-test 
  
 IL_1alpha 
    continuous 
    label 
    Interleukin 1 alpha 
    Interleukin 1 alpha 
    -7.54 (0.39) 
    -7.48 (0.43) 
    0.3035679 
    NA 
    Welch t-test 
    NA 
    TRUE 
    0.3035679 
    0.304 
    Welch t-test 
  
 IL_3 
    continuous 
    label 
    Interleukin 3 
    Interleukin 3 
    -3.93 (0.51) 
    -3.99 (0.50) 
    0.4067009 
    NA 
    Welch t-test 
    NA 
    TRUE 
    0.4067009 
    0.407 
    Welch t-test 
  
 IL_4 
    continuous 
    label 
    Interleukin 4 
    Interleukin 4 
    1.78 (0.50) 
    1.72 (0.53) 
    0.3623877 
    NA 
    Welch t-test 
    NA 
    TRUE 
    0.3623877 
    0.362 
    Welch t-test 
  
 IL_5 
    continuous 
    label 
    Interleukin 5 
    Interleukin 5 
    0.21 (0.46) 
    0.17 (0.44) 
    0.4598690 
    NA 
    Welch t-test 
    NA 
    TRUE 
    0.4598690 
    0.46 
    Welch t-test 
  
 IL_6 
    continuous 
    label 
    Interleukin 6 
    Interleukin 6 
    -0.15 (0.51) 
    -0.14 (0.62) 
    0.9841252 
    NA 
    Welch t-test 
    NA 
    TRUE 
    0.9841252 
    0.984 
    Welch t-test 
  
 IL_6_Receptor 
    continuous 
    label 
    Interleukin 6 receptor 
    Interleukin 6 receptor 
    0.09 (0.32) 
    0.08 (0.34) 
    0.8068581 
    NA 
    Welch t-test 
    NA 
    TRUE 
    0.8068581 
    0.807 
    Welch t-test 
  
 IL_7 
    continuous 
    label 
    Interleukin 7 
    Interleukin 7 
    3.01 (0.99) 
    2.61 (1.04) 
    0.0017584 
    NA 
    Welch t-test 
    NA 
    TRUE 
    0.0017584 
    0.00176 
    Welch t-test 
  
 IL_8 
    continuous 
    label 
    Interleukin 8 
    Interleukin 8 
    1.70 (0.03) 
    1.71 (0.04) 
    0.0318468 
    NA 
    Welch t-test 
    NA 
    TRUE 
    0.0318468 
    0.0318 
    Welch t-test 
  
 IP_10_Inducible_Protein_10 
    continuous 
    label 
    Inducible protein 10 
    Inducible protein 10 
    5.69 (0.51) 
    5.85 (0.48) 
    0.0084555 
    NA 
    Welch t-test 
    NA 
    TRUE 
    0.0084555 
    0.00846 
    Welch t-test 
  
 IgA 
    continuous 
    label 
    Immunoglobulin A 
    Immunoglobulin A 
    -6.17 (0.75) 
    -5.94 (0.69) 
    0.0078162 
    NA 
    Welch t-test 
    NA 
    TRUE 
    0.0078162 
    0.00782 
    Welch t-test 
  
 Insulin 
    continuous 
    label 
    Insulin 
    Insulin 
    -1.21 (0.33) 
    -1.26 (0.36) 
    0.2895756 
    NA 
    Welch t-test 
    NA 
    TRUE 
    0.2895756 
    0.29 
    Welch t-test 
  
 Kidney_Injury_Molecule_1_KIM_1 
    continuous 
    label 
    Kidney injury molecule 1 
    Kidney injury molecule 1 
    -1.19 (0.03) 
    -1.18 (0.02) 
    0.0048740 
    NA 
    Welch t-test 
    NA 
    TRUE 
    0.0048740 
    0.00487 
    Welch t-test 
  
 LOX_1 
    continuous 
    label 
    Lectin-like oxidized LDL receptor 1 
    Lectin-like oxidized LDL receptor 1 
    1.27 (0.40) 
    1.27 (0.45) 
    0.9876103 
    NA 
    Welch t-test 
    NA 
    TRUE 
    0.9876103 
    0.988 
    Welch t-test 
  
 Leptin 
    continuous 
    label 
    Leptin 
    Leptin 
    -1.48 (0.27) 
    -1.53 (0.26) 
    0.0940108 
    NA 
    Welch t-test 
    NA 
    TRUE 
    0.0940108 
    0.094 
    Welch t-test 
  
 Lipoprotein_a 
    continuous 
    label 
    Lipoprotein(a) 
    Lipoprotein(a) 
    -4.51 (1.03) 
    -4.25 (1.16) 
    0.0629993 
    NA 
    Welch t-test 
    NA 
    TRUE 
    0.0629993 
    0.063 
    Welch t-test 
  
 MCP_1 
    continuous 
    label 
    Monocyte chemoattractant protein 1 
    Monocyte chemoattractant protein 1 
    6.48 (0.26) 
    6.52 (0.25) 
    0.1775721 
    NA 
    Welch t-test 
    NA 
    TRUE 
    0.1775721 
    0.178 
    Welch t-test 
  
 MCP_2 
    continuous 
    label 
    Monocyte chemoattractant protein 2 
    Monocyte chemoattractant protein 2 
    1.78 (0.62) 
    2.07 (0.64) 
    0.0002487 
    NA 
    Welch t-test 
    NA 
    TRUE 
    0.0002487 
    <0.001 
    Welch t-test 
  
 MIF 
    continuous 
    label 
    Macrophage migration inhibitory factor 
    Macrophage migration inhibitory factor 
    -1.93 (0.33) 
    -1.74 (0.29) 
    0.0000004 
    NA 
    Welch t-test 
    NA 
    TRUE 
    0.0000004 
    <0.001 
    Welch t-test 
  
 MIP_1alpha 
    continuous 
    label 
    Macrophage inflammatory protein 1 alpha 
    Macrophage inflammatory protein 1 alpha 
    3.94 (1.05) 
    4.24 (0.88) 
    0.0083499 
    NA 
    Welch t-test 
    NA 
    TRUE 
    0.0083499 
    0.00835 
    Welch t-test 
  
 MIP_1beta 
    continuous 
    label 
    Macrophage inflammatory protein 1 beta 
    Macrophage inflammatory protein 1 beta 
    2.79 (0.38) 
    2.87 (0.40) 
    0.0869483 
    NA 
    Welch t-test 
    NA 
    TRUE 
    0.0869483 
    0.0869 
    Welch t-test 
  
 MMP_2 
    continuous 
    label 
    Matrix metalloproteinase 2 
    Matrix metalloproteinase 2 
    2.95 (0.95) 
    2.81 (0.89) 
    0.2122963 
    NA 
    Welch t-test 
    NA 
    TRUE 
    0.2122963 
    0.212 
    Welch t-test 
  
 MMP_3 
    continuous 
    label 
    Matrix metalloproteinase 3 
    Matrix metalloproteinase 3 
    -2.49 (0.56) 
    -2.36 (0.60) 
    0.0738423 
    NA 
    Welch t-test 
    NA 
    TRUE 
    0.0738423 
    0.0738 
    Welch t-test 
  
 MMP10 
    continuous 
    label 
    Matrix metalloproteinase 10 
    Matrix metalloproteinase 10 
    -3.73 (0.40) 
    -3.42 (0.44) 
    0.0000000 
    NA 
    Welch t-test 
    NA 
    TRUE 
    0.0000000 
    <0.001 
    Welch t-test 
  
 MMP7 
    continuous 
    label 
    Matrix metalloproteinase 7 
    Matrix metalloproteinase 7 
    -4.07 (1.58) 
    -3.21 (1.28) 
    0.0000009 
    NA 
    Welch t-test 
    NA 
    TRUE 
    0.0000009 
    <0.001 
    Welch t-test 
  
 Myoglobin 
    continuous 
    label 
    Myoglobin 
    Myoglobin 
    -1.43 (0.96) 
    -1.23 (0.87) 
    0.0755465 
    NA 
    Welch t-test 
    NA 
    TRUE 
    0.0755465 
    0.0755 
    Welch t-test 
  
 NT_proBNP 
    continuous 
    label 
    N-terminal pro b-type natriuretic peptide 
    N-terminal pro b-type natriuretic peptide 
    4.46 (0.36) 
    4.71 (0.36) 
    0.0000038 
    NA 
    Welch t-test 
    NA 
    TRUE 
    0.0000038 
    <0.001 
    Welch t-test 
  
 NrCAM 
    continuous 
    label 
    Neuron-glia cell adhesion molecule 
    Neuron-glia cell adhesion molecule 
    4.38 (0.56) 
    4.33 (0.54) 
    0.5219452 
    NA 
    Welch t-test 
    NA 
    TRUE 
    0.5219452 
    0.522 
    Welch t-test 
  
 Osteopontin 
    continuous 
    label 
    Osteopontin 
    Osteopontin 
    5.16 (0.38) 
    5.31 (0.41) 
    0.0022081 
    NA 
    Welch t-test 
    NA 
    TRUE 
    0.0022081 
    0.00221 
    Welch t-test 
  
 PAI_1 
    continuous 
    label 
    Plasminogen activator inhibitor 1 
    Plasminogen activator inhibitor 1 
    -0.01 (0.38) 
    0.26 (0.44) 
    0.0000007 
    NA 
    Welch t-test 
    NA 
    TRUE 
    0.0000007 
    <0.001 
    Welch t-test 
  
 PAPP_A 
    continuous 
    label 
    Pregnancy-associated plasma protein A 
    Pregnancy-associated plasma protein A 
    -2.85 (0.14) 
    -2.85 (0.14) 
    0.9612735 
    NA 
    Welch t-test 
    NA 
    TRUE 
    0.9612735 
    0.961 
    Welch t-test 
  
 PLGF 
    continuous 
    label 
    Placental growth factor 
    Placental growth factor 
    3.87 (0.39) 
    4.01 (0.42) 
    0.0045508 
    NA 
    Welch t-test 
    NA 
    TRUE 
    0.0045508 
    0.00455 
    Welch t-test 
  
 PYY 
    continuous 
    label 
    Peptide YY 
    Peptide YY 
    3.01 (0.29) 
    3.01 (0.28) 
    0.8747602 
    NA 
    Welch t-test 
    NA 
    TRUE 
    0.8747602 
    0.875 
    Welch t-test 
  
 Pancreatic_polypeptide 
    continuous 
    label 
    Pancreatic polypeptide 
    Pancreatic polypeptide 
    -0.14 (0.67) 
    0.32 (0.74) 
    0.0000008 
    NA 
    Welch t-test 
    NA 
    TRUE 
    0.0000008 
    <0.001 
    Welch t-test 
  
 Prolactin 
    continuous 
    label 
    Prolactin 
    Prolactin 
    0.03 (0.30) 
    0.09 (0.27) 
    0.1059084 
    NA 
    Welch t-test 
    NA 
    TRUE 
    0.1059084 
    0.106 
    Welch t-test 
  
 Prostatic_Acid_Phosphatase 
    continuous 
    label 
    Prostatic acid phosphatase 
    Prostatic acid phosphatase 
    -1.69 (0.06) 
    -1.68 (0.06) 
    0.0631539 
    NA 
    Welch t-test 
    NA 
    TRUE 
    0.0631539 
    0.0632 
    Welch t-test 
  
 Protein_S 
    continuous 
    label 
    Protein S 
    Protein S 
    -2.27 (0.36) 
    -2.17 (0.37) 
    0.0181327 
    NA 
    Welch t-test 
    NA 
    TRUE 
    0.0181327 
    0.0181 
    Welch t-test 
  
 Pulmonary_and_Activation_Regulat 
    continuous 
    label 
    Pulmonary and activation-regulated chemokine 
    Pulmonary and activation-regulated chemokine 
    -1.56 (0.47) 
    -1.47 (0.35) 
    0.1259992 
    NA 
    Welch t-test 
    NA 
    TRUE 
    0.1259992 
    0.126 
    Welch t-test 
  
 RANTES 
    continuous 
    label 
    Regulated on activation, normal T cell expressed and secreted 
    Regulated on activation, normal T cell expressed and secreted 
    -6.55 (0.31) 
    -6.44 (0.31) 
    0.0044494 
    NA 
    Welch t-test 
    NA 
    TRUE 
    0.0044494 
    0.00445 
    Welch t-test 
  
 Resistin 
    continuous 
    label 
    Resistin 
    Resistin 
    -18.52 (5.42) 
    -15.74 (5.93) 
    0.0001487 
    NA 
    Welch t-test 
    NA 
    TRUE 
    0.0001487 
    <0.001 
    Welch t-test 
  
 S100b 
    continuous 
    label 
    S100 calcium-binding protein B 
    S100 calcium-binding protein B 
    1.21 (0.35) 
    1.32 (0.34) 
    0.0078991 
    NA 
    Welch t-test 
    NA 
    TRUE 
    0.0078991 
    0.0079 
    Welch t-test 
  
 SGOT 
    continuous 
    label 
    Serum glutamic-oxaloacetic transaminase 
    Serum glutamic-oxaloacetic transaminase 
    -0.44 (0.37) 
    -0.37 (0.29) 
    0.0469909 
    NA 
    Welch t-test 
    NA 
    TRUE 
    0.0469909 
    0.047 
    Welch t-test 
  
 SHBG 
    continuous 
    label 
    Sex hormone-binding globulin 
    Sex hormone-binding globulin 
    -2.54 (0.57) 
    -2.45 (0.56) 
    0.1686214 
    NA 
    Welch t-test 
    NA 
    TRUE 
    0.1686214 
    0.169 
    Welch t-test 
  
 SOD 
    continuous 
    label 
    Superoxide dismutase 
    Superoxide dismutase 
    5.31 (0.38) 
    5.39 (0.38) 
    0.0833871 
    NA 
    Welch t-test 
    NA 
    TRUE 
    0.0833871 
    0.0834 
    Welch t-test 
  
 Serum_Amyloid_P 
    continuous 
    label 
    Serum amyloid P component 
    Serum amyloid P component 
    -6.05 (0.55) 
    -5.98 (0.57) 
    0.3236618 
    NA 
    Welch t-test 
    NA 
    TRUE 
    0.3236618 
    0.324 
    Welch t-test 
  
 Sortilin 
    continuous 
    label 
    Sortilin 
    Sortilin 
    3.74 (0.86) 
    4.10 (0.83) 
    0.0005339 
    NA 
    Welch t-test 
    NA 
    TRUE 
    0.0005339 
    <0.001 
    Welch t-test 
  
 Stem_Cell_Factor 
    continuous 
    label 
    Stem cell factor 
    Stem cell factor 
    3.30 (0.36) 
    3.28 (0.34) 
    0.6843984 
    NA 
    Welch t-test 
    NA 
    TRUE 
    0.6843984 
    0.684 
    Welch t-test 
  
 TGF_alpha 
    continuous 
    label 
    Transforming growth factor alpha 
    Transforming growth factor alpha 
    9.73 (1.31) 
    9.96 (1.18) 
    0.1283139 
    NA 
    Welch t-test 
    NA 
    TRUE 
    0.1283139 
    0.128 
    Welch t-test 
  
 TIMP_1 
    continuous 
    label 
    Tissue inhibitor of metalloproteinases 1 
    Tissue inhibitor of metalloproteinases 1 
    11.55 (1.78) 
    12.11 (1.97) 
    0.0209928 
    NA 
    Welch t-test 
    NA 
    TRUE 
    0.0209928 
    0.021 
    Welch t-test 
  
 TNF_RII 
    continuous 
    label 
    Tumor necrosis factor receptor II 
    Tumor necrosis factor receptor II 
    -0.64 (0.32) 
    -0.48 (0.35) 
    0.0002205 
    NA 
    Welch t-test 
    NA 
    TRUE 
    0.0002205 
    <0.001 
    Welch t-test 
  
 TRAIL_R3 
    continuous 
    label 
    TNF-related apoptosis-inducing ligand receptor 3 
    TNF-related apoptosis-inducing ligand receptor 3 
    -0.59 (0.23) 
    -0.43 (0.23) 
    0.0000001 
    NA 
    Welch t-test 
    NA 
    TRUE 
    0.0000001 
    <0.001 
    Welch t-test 
  
 TTR_prealbumin 
    continuous 
    label 
    Transthyretin (prealbumin) 
    Transthyretin (prealbumin) 
    2.86 (0.14) 
    2.84 (0.14) 
    0.4396330 
    NA 
    Welch t-test 
    NA 
    TRUE 
    0.4396330 
    0.44 
    Welch t-test 
  
 Tamm_Horsfall_Protein_THP 
    continuous 
    label 
    Tamm-Horsfall protein 
    Tamm-Horsfall protein 
    -3.12 (0.03) 
    -3.11 (0.03) 
    0.3283328 
    NA 
    Welch t-test 
    NA 
    TRUE 
    0.3283328 
    0.328 
    Welch t-test 
  
 Thrombomodulin 
    continuous 
    label 
    Thrombomodulin 
    Thrombomodulin 
    -1.53 (0.23) 
    -1.45 (0.22) 
    0.0028089 
    NA 
    Welch t-test 
    NA 
    TRUE 
    0.0028089 
    0.00281 
    Welch t-test 
  
 Thrombopoietin 
    continuous 
    label 
    Thrombopoietin 
    Thrombopoietin 
    -0.74 (0.24) 
    -0.81 (0.25) 
    0.0630863 
    NA 
    Welch t-test 
    NA 
    TRUE 
    0.0630863 
    0.0631 
    Welch t-test 
  
 Thymus_Expressed_Chemokine_TECK 
    continuous 
    label 
    Thymus-expressed chemokine (TECK) 
    Thymus-expressed chemokine (TECK) 
    3.73 (0.77) 
    4.11 (0.76) 
    0.0000606 
    NA 
    Welch t-test 
    NA 
    TRUE 
    0.0000606 
    <0.001 
    Welch t-test 
  
 Thyroid_Stimulating_Hormone 
    continuous 
    label 
    Thyroid-stimulating hormone 
    Thyroid-stimulating hormone 
    -4.45 (0.75) 
    -4.43 (0.82) 
    0.8817515 
    NA 
    Welch t-test 
    NA 
    TRUE 
    0.8817515 
    0.882 
    Welch t-test 
  
 Thyroxine_Binding_Globulin 
    continuous 
    label 
    Thyroxine-binding globulin 
    Thyroxine-binding globulin 
    -1.51 (0.40) 
    -1.42 (0.39) 
    0.0668355 
    NA 
    Welch t-test 
    NA 
    TRUE 
    0.0668355 
    0.0668 
    Welch t-test 
  
 Tissue_Factor 
    continuous 
    label 
    Tissue factor 
    Tissue factor 
    1.16 (0.51) 
    1.18 (0.51) 
    0.7382965 
    NA 
    Welch t-test 
    NA 
    TRUE 
    0.7382965 
    0.738 
    Welch t-test 
  
 Transferrin 
    continuous 
    label 
    Transferrin 
    Transferrin 
    2.90 (0.28) 
    2.92 (0.27) 
    0.5677089 
    NA 
    Welch t-test 
    NA 
    TRUE 
    0.5677089 
    0.568 
    Welch t-test 
  
 Trefoil_Factor_3_TFF3 
    continuous 
    label 
    Trefoil factor 3 (TFF3) 
    Trefoil factor 3 (TFF3) 
    -3.90 (0.33) 
    -3.85 (0.36) 
    0.2500022 
    NA 
    Welch t-test 
    NA 
    TRUE 
    0.2500022 
    0.25 
    Welch t-test 
  
 VCAM_1 
    continuous 
    label 
    Vascular cell adhesion molecule 1 
    Vascular cell adhesion molecule 1 
    2.66 (0.30) 
    2.73 (0.37) 
    0.0887835 
    NA 
    Welch t-test 
    NA 
    TRUE 
    0.0887835 
    0.0888 
    Welch t-test 
  
 VEGF 
    continuous 
    label 
    Vascular endothelial growth factor 
    Vascular endothelial growth factor 
    17.14 (1.85) 
    16.37 (1.83) 
    0.0008075 
    NA 
    Welch t-test 
    NA 
    TRUE 
    0.0008075 
    <0.001 
    Welch t-test 
  
 Vitronectin 
    continuous 
    label 
    Vitronectin 
    Vitronectin 
    -0.28 (0.33) 
    -0.28 (0.32) 
    0.9569334 
    NA 
    Welch t-test 
    NA 
    TRUE 
    0.9569334 
    0.957 
    Welch t-test 
  
 von_Willebrand_Factor 
    continuous 
    label 
    von Willebrand factor 
    von Willebrand factor 
    -3.95 (0.37) 
    -3.86 (0.39) 
    0.0473700 
    NA 
    Welch t-test 
    NA 
    TRUE 
    0.0473700 
    0.0474 
    Welch t-test 
  
 tau 
    continuous 
    label 
    Tau protein 
    Tau protein 
    5.61 (0.49) 
    6.14 (0.55) 
    0.0000000 
    NA 
    Welch t-test 
    NA 
    TRUE 
    0.0000000 
    <0.001 
    Welch t-test 
  
 p_tau 
    continuous 
    label 
    Phosphorylated tau protein 
    Phosphorylated tau protein 
    3.94 (0.42) 
    4.30 (0.48) 
    0.0000000 
    NA 
    Welch t-test 
    NA 
    TRUE 
    0.0000000 
    <0.001 
    Welch t-test 
  
 Ab_42 
    continuous 
    label 
    Amyloid beta 42 
    Amyloid beta 42 
    12.80 (1.41) 
    11.27 (1.34) 
    0.0000000 
    NA 
    Welch t-test 
    NA 
    TRUE 
    0.0000000 
    <0.001 
    Welch t-test 
  
# }